Engineering Docetaxel Micelles for Enhanced Cancer Therapy Through Intermolecular Forces
Docetaxel has exhibited excellent therapeutic effects in cancer treatment; however, its hydrophobicity, short blood circulation time, and high blood toxicity restrict its clinical application. The use of mPEG-PLA micelles to deliver docetaxel into the body has been verified as an effective approach...
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| Format: | Article |
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MDPI AG
2024-10-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/11/11/1078 |
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| author | Hao Wang Feirong Gong Jiajie Liu Lanlan Xiang Yanfen Hu Wenchen Che Ran Li Sisi Yang Qixin Zhuang Xin Teng |
| author_facet | Hao Wang Feirong Gong Jiajie Liu Lanlan Xiang Yanfen Hu Wenchen Che Ran Li Sisi Yang Qixin Zhuang Xin Teng |
| author_sort | Hao Wang |
| collection | DOAJ |
| description | Docetaxel has exhibited excellent therapeutic effects in cancer treatment; however, its hydrophobicity, short blood circulation time, and high blood toxicity restrict its clinical application. The use of mPEG-PLA micelles to deliver docetaxel into the body has been verified as an effective approach to enhance its therapeutic efficacy. However, mPEG-PLA micelles are easily disassembled in the bloodstream, which can easily lead to premature drug release. To broaden the application scenarios of mPEG PLA micelles, we utilized the π–π stacking effect as an intermolecular force to design a novel mPEG-PLA-Lys(Fmoc) micelle to enhance the blood stability and permeability of drug-loaded micelles. The result showed that drug-loaded micelles for injection did not alter the tissue selectivity of docetaxel. Intravenous injection of the micelles in nude mice showed better antitumor efficacy than docetaxel injection and tumor recurrence rate is 0%, which is significantly lower than that of docetaxel injection (100%). The micelles designed by this research institute are anticipated to improve the clinical therapeutic effect of docetaxel. |
| format | Article |
| id | doaj-art-1f3c19fa53c5426f96b0707cccfe6332 |
| institution | OA Journals |
| issn | 2306-5354 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj-art-1f3c19fa53c5426f96b0707cccfe63322025-08-20T02:28:01ZengMDPI AGBioengineering2306-53542024-10-011111107810.3390/bioengineering11111078Engineering Docetaxel Micelles for Enhanced Cancer Therapy Through Intermolecular ForcesHao Wang0Feirong Gong1Jiajie Liu2Lanlan Xiang3Yanfen Hu4Wenchen Che5Ran Li6Sisi Yang7Qixin Zhuang8Xin Teng9National Material Experimental Teaching Demonstration Center, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, ChinaNational Material Experimental Teaching Demonstration Center, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, ChinaNational Material Experimental Teaching Demonstration Center, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, ChinaNational Material Experimental Teaching Demonstration Center, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, ChinaNational Material Experimental Teaching Demonstration Center, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, ChinaNational Material Experimental Teaching Demonstration Center, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, ChinaNational Material Experimental Teaching Demonstration Center, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, ChinaNational Material Experimental Teaching Demonstration Center, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, ChinaNational Material Experimental Teaching Demonstration Center, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, ChinaNational Material Experimental Teaching Demonstration Center, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, ChinaDocetaxel has exhibited excellent therapeutic effects in cancer treatment; however, its hydrophobicity, short blood circulation time, and high blood toxicity restrict its clinical application. The use of mPEG-PLA micelles to deliver docetaxel into the body has been verified as an effective approach to enhance its therapeutic efficacy. However, mPEG-PLA micelles are easily disassembled in the bloodstream, which can easily lead to premature drug release. To broaden the application scenarios of mPEG PLA micelles, we utilized the π–π stacking effect as an intermolecular force to design a novel mPEG-PLA-Lys(Fmoc) micelle to enhance the blood stability and permeability of drug-loaded micelles. The result showed that drug-loaded micelles for injection did not alter the tissue selectivity of docetaxel. Intravenous injection of the micelles in nude mice showed better antitumor efficacy than docetaxel injection and tumor recurrence rate is 0%, which is significantly lower than that of docetaxel injection (100%). The micelles designed by this research institute are anticipated to improve the clinical therapeutic effect of docetaxel.https://www.mdpi.com/2306-5354/11/11/1078docetaxelnanomicellesdrug deliveryantitumorintermolecular force |
| spellingShingle | Hao Wang Feirong Gong Jiajie Liu Lanlan Xiang Yanfen Hu Wenchen Che Ran Li Sisi Yang Qixin Zhuang Xin Teng Engineering Docetaxel Micelles for Enhanced Cancer Therapy Through Intermolecular Forces Bioengineering docetaxel nanomicelles drug delivery antitumor intermolecular force |
| title | Engineering Docetaxel Micelles for Enhanced Cancer Therapy Through Intermolecular Forces |
| title_full | Engineering Docetaxel Micelles for Enhanced Cancer Therapy Through Intermolecular Forces |
| title_fullStr | Engineering Docetaxel Micelles for Enhanced Cancer Therapy Through Intermolecular Forces |
| title_full_unstemmed | Engineering Docetaxel Micelles for Enhanced Cancer Therapy Through Intermolecular Forces |
| title_short | Engineering Docetaxel Micelles for Enhanced Cancer Therapy Through Intermolecular Forces |
| title_sort | engineering docetaxel micelles for enhanced cancer therapy through intermolecular forces |
| topic | docetaxel nanomicelles drug delivery antitumor intermolecular force |
| url | https://www.mdpi.com/2306-5354/11/11/1078 |
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