Impact of an intensive outpatient rehabilitation on non-motor patients’ reported outcomes in PD: the INTENSO study
Abstract Non-motor symptoms in Parkinson’s disease (PD) can reduce quality of life and increase disability. This historical cohort study investigated how rehabilitation intensity influences non-motor symptoms. The primary outcomes were changes in non-motor symptoms in the short and medium term. Seco...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-06-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-01035-7 |
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| author | Marianna Capecci Nicolò Baldini Elisa Andrenelli Alice Lambertucci Paola Bisoglio Martina Grugnetti Hibel Margherita Maria Gabriella Ceravolo |
| author_facet | Marianna Capecci Nicolò Baldini Elisa Andrenelli Alice Lambertucci Paola Bisoglio Martina Grugnetti Hibel Margherita Maria Gabriella Ceravolo |
| author_sort | Marianna Capecci |
| collection | DOAJ |
| description | Abstract Non-motor symptoms in Parkinson’s disease (PD) can reduce quality of life and increase disability. This historical cohort study investigated how rehabilitation intensity influences non-motor symptoms. The primary outcomes were changes in non-motor symptoms in the short and medium term. Secondary outcomes were changes in disability burden, motor symptom severity, and freezing of gait after treatment. Measurements were taken before (T0) and after treatment (T1) and 6 ± 1 months after T1 (T2). According to total training duration, 24 patients with PD were assigned to High-Intensity Training group (HIT, 1800 min) and 24 to Low-Intensity Training (LIT, less than 900 minutes). At T1, only the HIT group showed clinically significant improvements in non-motor symptoms, which were maintained at T2. In contrast, the LIT group experienced worsening disability at follow-up. Multivariate analysis revealed training intensity and baseline disability as predictors of improvement. These findings support the benefits of high intensity exercise in PD management. |
| format | Article |
| id | doaj-art-1f31350cc7024da1abfe054f52876b7f |
| institution | OA Journals |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-1f31350cc7024da1abfe054f52876b7f2025-08-20T02:10:30ZengNature Portfolionpj Parkinson's Disease2373-80572025-06-011111810.1038/s41531-025-01035-7Impact of an intensive outpatient rehabilitation on non-motor patients’ reported outcomes in PD: the INTENSO studyMarianna Capecci0Nicolò Baldini1Elisa Andrenelli2Alice Lambertucci3Paola Bisoglio4Martina Grugnetti5Hibel Margherita6Maria Gabriella Ceravolo7Department of Experimental and Clinical Medicine, Politecnica delle Marche UniversityDepartment of Experimental and Clinical Medicine, Politecnica delle Marche UniversityDepartment of Experimental and Clinical Medicine, Politecnica delle Marche UniversityDepartment of Experimental and Clinical Medicine, Politecnica delle Marche UniversityDepartment of Experimental and Clinical Medicine, Politecnica delle Marche UniversityNeurorehabilitation Clinic, Marche University HospitalNeurorehabilitation Clinic, Marche University HospitalDepartment of Experimental and Clinical Medicine, Politecnica delle Marche UniversityAbstract Non-motor symptoms in Parkinson’s disease (PD) can reduce quality of life and increase disability. This historical cohort study investigated how rehabilitation intensity influences non-motor symptoms. The primary outcomes were changes in non-motor symptoms in the short and medium term. Secondary outcomes were changes in disability burden, motor symptom severity, and freezing of gait after treatment. Measurements were taken before (T0) and after treatment (T1) and 6 ± 1 months after T1 (T2). According to total training duration, 24 patients with PD were assigned to High-Intensity Training group (HIT, 1800 min) and 24 to Low-Intensity Training (LIT, less than 900 minutes). At T1, only the HIT group showed clinically significant improvements in non-motor symptoms, which were maintained at T2. In contrast, the LIT group experienced worsening disability at follow-up. Multivariate analysis revealed training intensity and baseline disability as predictors of improvement. These findings support the benefits of high intensity exercise in PD management.https://doi.org/10.1038/s41531-025-01035-7 |
| spellingShingle | Marianna Capecci Nicolò Baldini Elisa Andrenelli Alice Lambertucci Paola Bisoglio Martina Grugnetti Hibel Margherita Maria Gabriella Ceravolo Impact of an intensive outpatient rehabilitation on non-motor patients’ reported outcomes in PD: the INTENSO study npj Parkinson's Disease |
| title | Impact of an intensive outpatient rehabilitation on non-motor patients’ reported outcomes in PD: the INTENSO study |
| title_full | Impact of an intensive outpatient rehabilitation on non-motor patients’ reported outcomes in PD: the INTENSO study |
| title_fullStr | Impact of an intensive outpatient rehabilitation on non-motor patients’ reported outcomes in PD: the INTENSO study |
| title_full_unstemmed | Impact of an intensive outpatient rehabilitation on non-motor patients’ reported outcomes in PD: the INTENSO study |
| title_short | Impact of an intensive outpatient rehabilitation on non-motor patients’ reported outcomes in PD: the INTENSO study |
| title_sort | impact of an intensive outpatient rehabilitation on non motor patients reported outcomes in pd the intenso study |
| url | https://doi.org/10.1038/s41531-025-01035-7 |
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