Persistent Activation of Sphingosine‐1‐Phosphate Receptor 1 by Phytosphingosine‐3,4‐Cyclic Phosphate Ameliorates Sepsis by Inhibiting Hyperinflammation and Vascular Hyperpermeability

Persistent Activation of Sphingosine‐1‐Phosphate Receptor 1 by Phytosphingosine‐3,4‐Cyclic Phosphate Ameliorates Sepsis by Inhibiting Hyperinflammation and Vascular Hyperpermeability

ABSTRACT Sepsis is a life‐threatening disease characterized by multiorgan dysfunction caused by an abnormal immune response to microbial infection. Sphingosine‐1‐phosphate (S1P) levels are significantly lower in patients with sepsis and are negatively correlated with the severity of sepsis. However,...

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Main Authors: Suhong Duan, Seung‐Gook Kim, Jiaying Bao, Hyung‐Jin Lim, Joon Woo Kim, Sung‐Il Yoon, Young Jun Park, Sanguk Yun, Kye‐Seong Kim, Hwa‐Ryung Song, Myeong Jun Choi, Myung‐Kwan Han
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:MedComm
Subjects:
cecal ligation and puncture
phytosphingosine‐3,4‐cyclic phosphate
sepsis
sirtuin 1 (SIRT1)
sphingosine‐1‐phosphate
sphingosine‐1‐phosphate receptor 1
Online Access:https://doi.org/10.1002/mco2.70238
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