Targeting the brain-gut-prostate axis in chronic prostatitis: mechanisms and therapeutics
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), a refractory urinary system disorder, is closely associated with dysregulation of the brain-gut-prostate axis. Emerging evidence highlights the pivotal role of gut microbiota dysbiosis and its bidirectional interactions with the neuroimmune...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1628094/full |
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| author | Shiwei Song Shiwei Song Chunlei Zhang Bin Zhang Jinlong Yin Chang Yu Xuanrong Wang Qing Wang Fulin Ma Changfeng Yang Dehui Chang |
| author_facet | Shiwei Song Shiwei Song Chunlei Zhang Bin Zhang Jinlong Yin Chang Yu Xuanrong Wang Qing Wang Fulin Ma Changfeng Yang Dehui Chang |
| author_sort | Shiwei Song |
| collection | DOAJ |
| description | Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), a refractory urinary system disorder, is closely associated with dysregulation of the brain-gut-prostate axis. Emerging evidence highlights the pivotal role of gut microbiota dysbiosis and its bidirectional interactions with the neuroimmune system in CP/CPPS pathogenesis. This systematic review integrates perspectives from microbiomics, neuroimmunology, and metabolomics to propose a theoretical framework of the brain-gut-prostate axis and multi-dimensional therapeutic strategies targeting this axis. By transcending conventional localized anti-inflammatory approaches, these strategies aim to address clinical resistance and phenotypic heterogeneity. Mechanistic insights into microbiota-derived metabolites (e.g., short-chain fatty acids, SCFAs), neuroendocrine signaling (e.g., thyrotropin-releasing hormone, TRH), and immune crosstalk (e.g., Th17/Treg imbalance) are explored, alongside innovative therapies such as microbiome modulation, neural interventions, and immune regulation. This holistic paradigm not only provides new mechanistic insights but also offers promising avenues for personalized management and translational research in CP/CPPS, potentially overcoming current therapeutic bottlenecks. |
| format | Article |
| id | doaj-art-1f2bcf621e9740c4a527655ecef6cfcc |
| institution | DOAJ |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-1f2bcf621e9740c4a527655ecef6cfcc2025-08-20T02:44:28ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-07-011610.3389/fendo.2025.16280941628094Targeting the brain-gut-prostate axis in chronic prostatitis: mechanisms and therapeuticsShiwei Song0Shiwei Song1Chunlei Zhang2Bin Zhang3Jinlong Yin4Chang Yu5Xuanrong Wang6Qing Wang7Fulin Ma8Changfeng Yang9Dehui Chang10Department of Urology, 940th Hospital of the Joint Logistics Support Force, Lanzhou, ChinaFirst School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, ChinaDepartment of Urology, 940th Hospital of the Joint Logistics Support Force, Lanzhou, ChinaDepartment of Urology, 940th Hospital of the Joint Logistics Support Force, Lanzhou, ChinaFirst School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, ChinaFirst School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, ChinaFirst School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, ChinaFirst School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, ChinaFirst School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, ChinaFirst School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, ChinaDepartment of Urology, 940th Hospital of the Joint Logistics Support Force, Lanzhou, ChinaChronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), a refractory urinary system disorder, is closely associated with dysregulation of the brain-gut-prostate axis. Emerging evidence highlights the pivotal role of gut microbiota dysbiosis and its bidirectional interactions with the neuroimmune system in CP/CPPS pathogenesis. This systematic review integrates perspectives from microbiomics, neuroimmunology, and metabolomics to propose a theoretical framework of the brain-gut-prostate axis and multi-dimensional therapeutic strategies targeting this axis. By transcending conventional localized anti-inflammatory approaches, these strategies aim to address clinical resistance and phenotypic heterogeneity. Mechanistic insights into microbiota-derived metabolites (e.g., short-chain fatty acids, SCFAs), neuroendocrine signaling (e.g., thyrotropin-releasing hormone, TRH), and immune crosstalk (e.g., Th17/Treg imbalance) are explored, alongside innovative therapies such as microbiome modulation, neural interventions, and immune regulation. This holistic paradigm not only provides new mechanistic insights but also offers promising avenues for personalized management and translational research in CP/CPPS, potentially overcoming current therapeutic bottlenecks.https://www.frontiersin.org/articles/10.3389/fendo.2025.1628094/fullchronic prostatitisgut microbiotaneuroimmune interactionstherapeuticsCP/CPPS |
| spellingShingle | Shiwei Song Shiwei Song Chunlei Zhang Bin Zhang Jinlong Yin Chang Yu Xuanrong Wang Qing Wang Fulin Ma Changfeng Yang Dehui Chang Targeting the brain-gut-prostate axis in chronic prostatitis: mechanisms and therapeutics Frontiers in Endocrinology chronic prostatitis gut microbiota neuroimmune interactions therapeutics CP/CPPS |
| title | Targeting the brain-gut-prostate axis in chronic prostatitis: mechanisms and therapeutics |
| title_full | Targeting the brain-gut-prostate axis in chronic prostatitis: mechanisms and therapeutics |
| title_fullStr | Targeting the brain-gut-prostate axis in chronic prostatitis: mechanisms and therapeutics |
| title_full_unstemmed | Targeting the brain-gut-prostate axis in chronic prostatitis: mechanisms and therapeutics |
| title_short | Targeting the brain-gut-prostate axis in chronic prostatitis: mechanisms and therapeutics |
| title_sort | targeting the brain gut prostate axis in chronic prostatitis mechanisms and therapeutics |
| topic | chronic prostatitis gut microbiota neuroimmune interactions therapeutics CP/CPPS |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1628094/full |
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