The Association Between Early Graft Function, Donor Type and Long-Term Kidney Transplant Outcomes
Delayed graft function (DGF), is associated with inferior graft outcomes. Whether poor graft function without dialysis, termed slow graft function (SGF), affects outcomes is unclear. We investigated associations between SGF (serum creatinine dropping by less than 30% between days 1 and 2), DGF and g...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
|
| Series: | Transplant International |
| Subjects: | |
| Online Access: | https://www.frontierspartnerships.org/articles/10.3389/ti.2025.14197/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849726388667416576 |
|---|---|
| author | Karthik Venkataraman Karthik Venkataraman Karthik Venkataraman Georgina L. Irish Georgina L. Irish Georgina L. Irish Michael G. Collins Michael G. Collins Michael G. Collins Philip A. Clayton Philip A. Clayton Philip A. Clayton |
| author_facet | Karthik Venkataraman Karthik Venkataraman Karthik Venkataraman Georgina L. Irish Georgina L. Irish Georgina L. Irish Michael G. Collins Michael G. Collins Michael G. Collins Philip A. Clayton Philip A. Clayton Philip A. Clayton |
| author_sort | Karthik Venkataraman |
| collection | DOAJ |
| description | Delayed graft function (DGF), is associated with inferior graft outcomes. Whether poor graft function without dialysis, termed slow graft function (SGF), affects outcomes is unclear. We investigated associations between SGF (serum creatinine dropping by less than 30% between days 1 and 2), DGF and graft outcomes by donor type in a cohort of 17,579 Australian and New Zealand kidney transplant recipients from 2001–2021. The primary outcomes were graft survival and death-censored graft survival Compared with immediate graft function, both SGF (Adjusted hazard ratio [aHR] 1.48 (95% CI 1.14–1.91) and DGF [aHR 1.97 (1.42–2.73)] were associated with reduced graft survival in living donor and donation after brain death (DBD) recipients [SGF aHR 1.13 (1.01–1.27); DGF aHR 1.37 (1.24–1.51)]. In donation after circulatory death (DCD) recipients, DGF [(aHR 1.52 (1.13–2.04)] but not SGF [(aHR 1.55 (1.13–2.13)] was associated with reduced graft survival. Findings were similar for death-censored graft survival. In secondary analyses, SGFwas associated with reduced patient survival in living donor recipients. SGF and DGF were associated with lower 12-month eGFR for all donor types. DGF increased the odds of rejection for all donor types; for SGF this association was significant only for DBD recipients. SGF is associated with adverse outcomes in live donor and DBD kidney recipients. |
| format | Article |
| id | doaj-art-1f1f3e56ffbf44c09beaca73771c3926 |
| institution | DOAJ |
| issn | 1432-2277 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Transplant International |
| spelling | doaj-art-1f1f3e56ffbf44c09beaca73771c39262025-08-20T03:10:11ZengFrontiers Media S.A.Transplant International1432-22772025-05-013810.3389/ti.2025.1419714197The Association Between Early Graft Function, Donor Type and Long-Term Kidney Transplant OutcomesKarthik Venkataraman0Karthik Venkataraman1Karthik Venkataraman2Georgina L. Irish3Georgina L. Irish4Georgina L. Irish5Michael G. Collins6Michael G. Collins7Michael G. Collins8Philip A. Clayton9Philip A. Clayton10Philip A. Clayton11Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, AustraliaCentral and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA, AustraliaTransplant Epidemiology Group (TrEG), Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, AustraliaFaculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, AustraliaCentral and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA, AustraliaTransplant Epidemiology Group (TrEG), Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, AustraliaFaculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, AustraliaCentral and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA, AustraliaTransplant Epidemiology Group (TrEG), Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, AustraliaFaculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, AustraliaCentral and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, SA, AustraliaTransplant Epidemiology Group (TrEG), Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, AustraliaDelayed graft function (DGF), is associated with inferior graft outcomes. Whether poor graft function without dialysis, termed slow graft function (SGF), affects outcomes is unclear. We investigated associations between SGF (serum creatinine dropping by less than 30% between days 1 and 2), DGF and graft outcomes by donor type in a cohort of 17,579 Australian and New Zealand kidney transplant recipients from 2001–2021. The primary outcomes were graft survival and death-censored graft survival Compared with immediate graft function, both SGF (Adjusted hazard ratio [aHR] 1.48 (95% CI 1.14–1.91) and DGF [aHR 1.97 (1.42–2.73)] were associated with reduced graft survival in living donor and donation after brain death (DBD) recipients [SGF aHR 1.13 (1.01–1.27); DGF aHR 1.37 (1.24–1.51)]. In donation after circulatory death (DCD) recipients, DGF [(aHR 1.52 (1.13–2.04)] but not SGF [(aHR 1.55 (1.13–2.13)] was associated with reduced graft survival. Findings were similar for death-censored graft survival. In secondary analyses, SGFwas associated with reduced patient survival in living donor recipients. SGF and DGF were associated with lower 12-month eGFR for all donor types. DGF increased the odds of rejection for all donor types; for SGF this association was significant only for DBD recipients. SGF is associated with adverse outcomes in live donor and DBD kidney recipients.https://www.frontierspartnerships.org/articles/10.3389/ti.2025.14197/fullgraft functionkidney transplantANZDATAgraft survivaldelayed graft function (DGF) |
| spellingShingle | Karthik Venkataraman Karthik Venkataraman Karthik Venkataraman Georgina L. Irish Georgina L. Irish Georgina L. Irish Michael G. Collins Michael G. Collins Michael G. Collins Philip A. Clayton Philip A. Clayton Philip A. Clayton The Association Between Early Graft Function, Donor Type and Long-Term Kidney Transplant Outcomes Transplant International graft function kidney transplant ANZDATA graft survival delayed graft function (DGF) |
| title | The Association Between Early Graft Function, Donor Type and Long-Term Kidney Transplant Outcomes |
| title_full | The Association Between Early Graft Function, Donor Type and Long-Term Kidney Transplant Outcomes |
| title_fullStr | The Association Between Early Graft Function, Donor Type and Long-Term Kidney Transplant Outcomes |
| title_full_unstemmed | The Association Between Early Graft Function, Donor Type and Long-Term Kidney Transplant Outcomes |
| title_short | The Association Between Early Graft Function, Donor Type and Long-Term Kidney Transplant Outcomes |
| title_sort | association between early graft function donor type and long term kidney transplant outcomes |
| topic | graft function kidney transplant ANZDATA graft survival delayed graft function (DGF) |
| url | https://www.frontierspartnerships.org/articles/10.3389/ti.2025.14197/full |
| work_keys_str_mv | AT karthikvenkataraman theassociationbetweenearlygraftfunctiondonortypeandlongtermkidneytransplantoutcomes AT karthikvenkataraman theassociationbetweenearlygraftfunctiondonortypeandlongtermkidneytransplantoutcomes AT karthikvenkataraman theassociationbetweenearlygraftfunctiondonortypeandlongtermkidneytransplantoutcomes AT georginalirish theassociationbetweenearlygraftfunctiondonortypeandlongtermkidneytransplantoutcomes AT georginalirish theassociationbetweenearlygraftfunctiondonortypeandlongtermkidneytransplantoutcomes AT georginalirish theassociationbetweenearlygraftfunctiondonortypeandlongtermkidneytransplantoutcomes AT michaelgcollins theassociationbetweenearlygraftfunctiondonortypeandlongtermkidneytransplantoutcomes AT michaelgcollins theassociationbetweenearlygraftfunctiondonortypeandlongtermkidneytransplantoutcomes AT michaelgcollins theassociationbetweenearlygraftfunctiondonortypeandlongtermkidneytransplantoutcomes AT philipaclayton theassociationbetweenearlygraftfunctiondonortypeandlongtermkidneytransplantoutcomes AT philipaclayton theassociationbetweenearlygraftfunctiondonortypeandlongtermkidneytransplantoutcomes AT philipaclayton theassociationbetweenearlygraftfunctiondonortypeandlongtermkidneytransplantoutcomes AT karthikvenkataraman associationbetweenearlygraftfunctiondonortypeandlongtermkidneytransplantoutcomes AT karthikvenkataraman associationbetweenearlygraftfunctiondonortypeandlongtermkidneytransplantoutcomes AT karthikvenkataraman associationbetweenearlygraftfunctiondonortypeandlongtermkidneytransplantoutcomes AT georginalirish associationbetweenearlygraftfunctiondonortypeandlongtermkidneytransplantoutcomes AT georginalirish associationbetweenearlygraftfunctiondonortypeandlongtermkidneytransplantoutcomes AT georginalirish associationbetweenearlygraftfunctiondonortypeandlongtermkidneytransplantoutcomes AT michaelgcollins associationbetweenearlygraftfunctiondonortypeandlongtermkidneytransplantoutcomes AT michaelgcollins associationbetweenearlygraftfunctiondonortypeandlongtermkidneytransplantoutcomes AT michaelgcollins associationbetweenearlygraftfunctiondonortypeandlongtermkidneytransplantoutcomes AT philipaclayton associationbetweenearlygraftfunctiondonortypeandlongtermkidneytransplantoutcomes AT philipaclayton associationbetweenearlygraftfunctiondonortypeandlongtermkidneytransplantoutcomes AT philipaclayton associationbetweenearlygraftfunctiondonortypeandlongtermkidneytransplantoutcomes |