Search for clinical, genetic, morphological and immunohistochemical predictors of parathyroid cancer recurrence
Background. Currently, there is no consensus on postoperative risk stratification for parathyroid cancer (PC). The risk factors of disease progression are crucial for choosing the optimal treatment strategy, including adjuvant methods and patient,s follow-up. Aim. Identifying predictors of PC rec...
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| Language: | Russian |
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"Consilium Medicum" Publishing house
2024-12-01
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| Series: | Терапевтический архив |
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| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/633463/pdf |
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| author | Ekaterina I. Kim Anna K. Eremkina Alina R. Elfimova Natalia G. Mokrysheva |
| author_facet | Ekaterina I. Kim Anna K. Eremkina Alina R. Elfimova Natalia G. Mokrysheva |
| author_sort | Ekaterina I. Kim |
| collection | DOAJ |
| description | Background. Currently, there is no consensus on postoperative risk stratification for parathyroid cancer (PC). The risk factors of disease progression are crucial for choosing the optimal treatment strategy, including adjuvant methods and patient,s follow-up.
Aim. Identifying predictors of PC recurrence
Materials and methods. We performed a retrospective observational study of 85 patients with verified PC divided into remission (n=61) and recurrence (n=19) groups after primary surgical treatment for the period 2004–2023. The analyzed parameters included demographic, laboratory and instrumental data of patients with PC, the presence of a mutation in the CDC73 gene, morphological and immunohistochemical characteristics of the primary tumor.
Results. After adjustments for multiple comparisons, a statistically significant association of recurrence was found for preoperative calcium level (p0.001), pT4 stage (p0.001) according to TNM-classification (Tumor, Nodus, Metastasis) American Joint Committee on Cancer 2017. There was a statistical trend for calcium correction for hypoalbuminemia (p=0.002), presence of nephrolithiasis/nephrocalcinosis (p=0.021), parathyroid hormone level 6 months after primary surgery (p0.05), pT3 stage TNM (p=0.007), nuclear expression of parafibromin in tumor tissue (p0.05). We did not reveal any associations between disease recurrence and sex, age, volume of surgical treatment, germline mutation in the CDC73, parafibromin expression and Ki-67 in tumor tissue.
Conclusion. Our study revealed several factors of poor prognosis, allowing to identify a risk group for recurrence, which can contribute to active dynamic monitoring and timely treatment. |
| format | Article |
| id | doaj-art-1f1c210521bf4d37a8c8852117b1173c |
| institution | Kabale University |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| publishDate | 2024-12-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj-art-1f1c210521bf4d37a8c8852117b1173c2025-01-21T11:09:17Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422024-12-01961095896710.26442/00403660.2024.10.20287278565Search for clinical, genetic, morphological and immunohistochemical predictors of parathyroid cancer recurrenceEkaterina I. Kim0https://orcid.org/0000-0001-7879-8495Anna K. Eremkina1https://orcid.org/0000-0001-6667-062XAlina R. Elfimova2https://orcid.org/0000-0001-6935-3187Natalia G. Mokrysheva3https://orcid.org/0000-0002-9717-9742Endocrinology Research CenterEndocrinology Research CenterEndocrinology Research CenterEndocrinology Research CenterBackground. Currently, there is no consensus on postoperative risk stratification for parathyroid cancer (PC). The risk factors of disease progression are crucial for choosing the optimal treatment strategy, including adjuvant methods and patient,s follow-up. Aim. Identifying predictors of PC recurrence Materials and methods. We performed a retrospective observational study of 85 patients with verified PC divided into remission (n=61) and recurrence (n=19) groups after primary surgical treatment for the period 2004–2023. The analyzed parameters included demographic, laboratory and instrumental data of patients with PC, the presence of a mutation in the CDC73 gene, morphological and immunohistochemical characteristics of the primary tumor. Results. After adjustments for multiple comparisons, a statistically significant association of recurrence was found for preoperative calcium level (p0.001), pT4 stage (p0.001) according to TNM-classification (Tumor, Nodus, Metastasis) American Joint Committee on Cancer 2017. There was a statistical trend for calcium correction for hypoalbuminemia (p=0.002), presence of nephrolithiasis/nephrocalcinosis (p=0.021), parathyroid hormone level 6 months after primary surgery (p0.05), pT3 stage TNM (p=0.007), nuclear expression of parafibromin in tumor tissue (p0.05). We did not reveal any associations between disease recurrence and sex, age, volume of surgical treatment, germline mutation in the CDC73, parafibromin expression and Ki-67 in tumor tissue. Conclusion. Our study revealed several factors of poor prognosis, allowing to identify a risk group for recurrence, which can contribute to active dynamic monitoring and timely treatment.https://ter-arkhiv.ru/0040-3660/article/viewFile/633463/pdfprimary hyperparathyroidismparathyroid cancerdisease-free survivaldiagnostics |
| spellingShingle | Ekaterina I. Kim Anna K. Eremkina Alina R. Elfimova Natalia G. Mokrysheva Search for clinical, genetic, morphological and immunohistochemical predictors of parathyroid cancer recurrence Терапевтический архив primary hyperparathyroidism parathyroid cancer disease-free survival diagnostics |
| title | Search for clinical, genetic, morphological and immunohistochemical predictors of parathyroid cancer recurrence |
| title_full | Search for clinical, genetic, morphological and immunohistochemical predictors of parathyroid cancer recurrence |
| title_fullStr | Search for clinical, genetic, morphological and immunohistochemical predictors of parathyroid cancer recurrence |
| title_full_unstemmed | Search for clinical, genetic, morphological and immunohistochemical predictors of parathyroid cancer recurrence |
| title_short | Search for clinical, genetic, morphological and immunohistochemical predictors of parathyroid cancer recurrence |
| title_sort | search for clinical genetic morphological and immunohistochemical predictors of parathyroid cancer recurrence |
| topic | primary hyperparathyroidism parathyroid cancer disease-free survival diagnostics |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/633463/pdf |
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