Development of electrospun chitosan/polyvinyl alcohol membranes with antibacterial properties for enhanced open wound healing
This work focuses on using the electrospinning process to fabricate a microfiber membrane for wound healing by combination of chitosan (CS) and polyvinyl alcohol (PVA). The impacts of several parameters on fiber morphology and antibacterial capabilities, such as PVA concentration, CS/PVA ratio, app...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Can Tho University Publisher
2025-03-01
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| Series: | CTU Journal of Innovation and Sustainable Development |
| Subjects: | |
| Online Access: | https://ctujs.ctu.edu.vn/index.php/ctujs/article/view/917 |
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| Summary: | This work focuses on using the electrospinning process to fabricate a microfiber membrane for wound healing by combination of chitosan (CS) and polyvinyl alcohol (PVA). The impacts of several parameters on fiber morphology and antibacterial capabilities, such as PVA concentration, CS/PVA ratio, applied voltage, injection distance, and solution injection speed, were investigated. The ideal parameters for the electrospinning process were identified as follows: PVA concentration of 15%, CS/PVA ratio of 3/7, collecting distance of 10 cm, voltage of 11 kV, and flow rate of 0.085 mL/h. Scanning electron microscopy verified the fiber structure was homogeneous and particle-free, with an average diameter of 457 ± 111 nm. The CS/PVA microfiber membrane demonstrated strong antibacterial action against E. coli and L. monocytogenes strains. After 12 days, in-vivo tests demonstrated that the wound-healing capacity of the CS/PVA microfiber membrane was quicker than that of a self-healed wound sample. These results demonstrate the effective creation of CS/PVA microfibers for wound healing applications.
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| ISSN: | 2588-1418 2815-6412 |