Cell communication and relevant signaling pathways in osteogenesis–angiogenesis coupling
Abstract Osteogenesis is the process of bone formation mediated by the osteoblasts, participating in various bone-related physiological processes including bone development, bone homeostasis and fracture healing. It exhibits temporal and spatial interconnectivity with angiogenesis, constructed by mu...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-04-01
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| Series: | Bone Research |
| Online Access: | https://doi.org/10.1038/s41413-025-00417-0 |
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| author | Shuqing Li Xinjia Cai Jiahe Guo Xiaolu Li Wen Li Yan Liu Mengchun Qi |
| author_facet | Shuqing Li Xinjia Cai Jiahe Guo Xiaolu Li Wen Li Yan Liu Mengchun Qi |
| author_sort | Shuqing Li |
| collection | DOAJ |
| description | Abstract Osteogenesis is the process of bone formation mediated by the osteoblasts, participating in various bone-related physiological processes including bone development, bone homeostasis and fracture healing. It exhibits temporal and spatial interconnectivity with angiogenesis, constructed by multiple forms of cell communication occurring between bone and vascular endothelial cells. Molecular regulation among different cell types is crucial for coordinating osteogenesis and angiogenesis to facilitate bone remodeling, fracture healing, and other bone-related processes. The transmission of signaling molecules and the activation of their corresponding signal pathways are indispensable for various forms of cell communication. This communication acts as a “bridge” in coupling osteogenesis to angiogenesis. This article reviews the modes and processes of cell communication in osteogenesis-angiogenesis coupling over the past decade, mainly focusing on interactions among bone-related cells and vascular endothelial cells to provide insights into the mechanism of cell communication of osteogenesis-angiogenesis coupling in different bone-related contexts. Moreover, clinical relevance and applications are also introduced in this review. |
| format | Article |
| id | doaj-art-1f19ecc69eb0481fac2f109e846b41f4 |
| institution | DOAJ |
| issn | 2095-6231 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Bone Research |
| spelling | doaj-art-1f19ecc69eb0481fac2f109e846b41f42025-08-20T03:10:06ZengNature Publishing GroupBone Research2095-62312025-04-0113112410.1038/s41413-025-00417-0Cell communication and relevant signaling pathways in osteogenesis–angiogenesis couplingShuqing Li0Xinjia Cai1Jiahe Guo2Xiaolu Li3Wen Li4Yan Liu5Mengchun Qi6Department of Oral & Maxillofacial Surgery, College of Stomatology, North China University of Science and TechnologyCentral Laboratory, Peking University School and Hospital for Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials & National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesDepartment of Oral & Maxillofacial Surgery, College of Stomatology, North China University of Science and TechnologyDepartment of Oral & Maxillofacial Surgery, College of Stomatology, North China University of Science and TechnologyDepartment of Oral & Maxillofacial Surgery, College of Stomatology, North China University of Science and TechnologyCentral Laboratory, Peking University School and Hospital for Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials & National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesDepartment of Oral & Maxillofacial Surgery, College of Stomatology, North China University of Science and TechnologyAbstract Osteogenesis is the process of bone formation mediated by the osteoblasts, participating in various bone-related physiological processes including bone development, bone homeostasis and fracture healing. It exhibits temporal and spatial interconnectivity with angiogenesis, constructed by multiple forms of cell communication occurring between bone and vascular endothelial cells. Molecular regulation among different cell types is crucial for coordinating osteogenesis and angiogenesis to facilitate bone remodeling, fracture healing, and other bone-related processes. The transmission of signaling molecules and the activation of their corresponding signal pathways are indispensable for various forms of cell communication. This communication acts as a “bridge” in coupling osteogenesis to angiogenesis. This article reviews the modes and processes of cell communication in osteogenesis-angiogenesis coupling over the past decade, mainly focusing on interactions among bone-related cells and vascular endothelial cells to provide insights into the mechanism of cell communication of osteogenesis-angiogenesis coupling in different bone-related contexts. Moreover, clinical relevance and applications are also introduced in this review.https://doi.org/10.1038/s41413-025-00417-0 |
| spellingShingle | Shuqing Li Xinjia Cai Jiahe Guo Xiaolu Li Wen Li Yan Liu Mengchun Qi Cell communication and relevant signaling pathways in osteogenesis–angiogenesis coupling Bone Research |
| title | Cell communication and relevant signaling pathways in osteogenesis–angiogenesis coupling |
| title_full | Cell communication and relevant signaling pathways in osteogenesis–angiogenesis coupling |
| title_fullStr | Cell communication and relevant signaling pathways in osteogenesis–angiogenesis coupling |
| title_full_unstemmed | Cell communication and relevant signaling pathways in osteogenesis–angiogenesis coupling |
| title_short | Cell communication and relevant signaling pathways in osteogenesis–angiogenesis coupling |
| title_sort | cell communication and relevant signaling pathways in osteogenesis angiogenesis coupling |
| url | https://doi.org/10.1038/s41413-025-00417-0 |
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