Methotrexate-induced leukoencephalopathy. A case report
A six-year-old girl with non-Hodgkin's lymphoma who was treated with both intravenous (IV) and intrathecal (IT) methotrexate and developed brain damage secondary to the cytostatic drug is described. This patient displayed hypertension, hypothermia/hyperthermia, lethargy, deterioration an...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hacettepe University Institute of Child Health
1995-07-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/3573 |
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| _version_ | 1850033372028469248 |
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| author | I Ilhan A Cila M Büyükpamukçu C Akyüz T Kutluk S Berberoğlu |
| author_facet | I Ilhan A Cila M Büyükpamukçu C Akyüz T Kutluk S Berberoğlu |
| author_sort | I Ilhan |
| collection | DOAJ |
| description |
A six-year-old girl with non-Hodgkin's lymphoma who was treated with both intravenous (IV) and intrathecal (IT) methotrexate and developed brain damage secondary to the cytostatic drug is described. This patient displayed hypertension, hypothermia/hyperthermia, lethargy, deterioration and coma as clinical findings, and bilateral, focal white matter hyperintensities in the occipital lobes were seen in her magnetic resonance imaging (MRI). Treatment-related leukoencephalopathy is one such adverse effect of IT methotrexate administration on the central nervous system and usually appears in a generalized form.
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| format | Article |
| id | doaj-art-1f1920a0791c45028030040188482bdb |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 1995-07-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-1f1920a0791c45028030040188482bdb2025-08-20T02:58:15ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64211995-07-01373Methotrexate-induced leukoencephalopathy. A case reportI Ilhan0A CilaM BüyükpamukçuC AkyüzT KutlukS BerberoğluDepartment of Pediatrics, Hacettepe University Faculty of Medicine, Ankara. A six-year-old girl with non-Hodgkin's lymphoma who was treated with both intravenous (IV) and intrathecal (IT) methotrexate and developed brain damage secondary to the cytostatic drug is described. This patient displayed hypertension, hypothermia/hyperthermia, lethargy, deterioration and coma as clinical findings, and bilateral, focal white matter hyperintensities in the occipital lobes were seen in her magnetic resonance imaging (MRI). Treatment-related leukoencephalopathy is one such adverse effect of IT methotrexate administration on the central nervous system and usually appears in a generalized form. https://turkjpediatr.org/article/view/3573 |
| spellingShingle | I Ilhan A Cila M Büyükpamukçu C Akyüz T Kutluk S Berberoğlu Methotrexate-induced leukoencephalopathy. A case report The Turkish Journal of Pediatrics |
| title | Methotrexate-induced leukoencephalopathy. A case report |
| title_full | Methotrexate-induced leukoencephalopathy. A case report |
| title_fullStr | Methotrexate-induced leukoencephalopathy. A case report |
| title_full_unstemmed | Methotrexate-induced leukoencephalopathy. A case report |
| title_short | Methotrexate-induced leukoencephalopathy. A case report |
| title_sort | methotrexate induced leukoencephalopathy a case report |
| url | https://turkjpediatr.org/article/view/3573 |
| work_keys_str_mv | AT iilhan methotrexateinducedleukoencephalopathyacasereport AT acila methotrexateinducedleukoencephalopathyacasereport AT mbuyukpamukcu methotrexateinducedleukoencephalopathyacasereport AT cakyuz methotrexateinducedleukoencephalopathyacasereport AT tkutluk methotrexateinducedleukoencephalopathyacasereport AT sberberoglu methotrexateinducedleukoencephalopathyacasereport |