Possible Roles of Ectophosphatases in Host-Parasite Interactions
The interaction and survival of pathogens in hostile environments and in confrontation with host immune responses are important mechanisms for the establishment of infection. Ectophosphatases are enzymes localized at the plasma membrane of cells, and their active sites face the external medium rathe...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Parasitology Research |
| Online Access: | http://dx.doi.org/10.1155/2011/479146 |
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| author | Marta T. Gomes Angela H. Lopes José Roberto Meyer-Fernandes |
| author_facet | Marta T. Gomes Angela H. Lopes José Roberto Meyer-Fernandes |
| author_sort | Marta T. Gomes |
| collection | DOAJ |
| description | The interaction and survival of pathogens in hostile environments and in confrontation with host immune responses are important mechanisms for the establishment of infection. Ectophosphatases are enzymes localized at the plasma membrane of cells, and their active sites face the external medium rather than the cytoplasm. Once activated, these enzymes are able to hydrolyze phosphorylated substrates in the extracellular milieu. Several studies demonstrated the presence of surface-located ecto-phosphatases in a vast number of pathogenic organisms, including bacteria, protozoa, and fungi. Little is known about the role of ecto-phosphatases in host-pathogen interactions. The present paper provides an overview of recent findings related to the virulence induced by these surface molecules in protozoa and fungi. |
| format | Article |
| id | doaj-art-1f16ed0467274fccb99eeee56777e1cf |
| institution | Kabale University |
| issn | 2090-0023 2090-0031 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Parasitology Research |
| spelling | doaj-art-1f16ed0467274fccb99eeee56777e1cf2025-08-20T03:54:36ZengWileyJournal of Parasitology Research2090-00232090-00312011-01-01201110.1155/2011/479146479146Possible Roles of Ectophosphatases in Host-Parasite InteractionsMarta T. Gomes0Angela H. Lopes1José Roberto Meyer-Fernandes2Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, CCS, Bloco H, Cidade Universitária, Ilha do Fundão, 21941-902 Rio de Janeiro, RJ, BrazilInstituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, CCS, Bloco H, Cidade Universitária, Ilha do Fundão, 21941-902 Rio de Janeiro, RJ, BrazilInstituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, CCS, Bloco H, Cidade Universitária, Ilha do Fundão, 21941-902 Rio de Janeiro, RJ, BrazilThe interaction and survival of pathogens in hostile environments and in confrontation with host immune responses are important mechanisms for the establishment of infection. Ectophosphatases are enzymes localized at the plasma membrane of cells, and their active sites face the external medium rather than the cytoplasm. Once activated, these enzymes are able to hydrolyze phosphorylated substrates in the extracellular milieu. Several studies demonstrated the presence of surface-located ecto-phosphatases in a vast number of pathogenic organisms, including bacteria, protozoa, and fungi. Little is known about the role of ecto-phosphatases in host-pathogen interactions. The present paper provides an overview of recent findings related to the virulence induced by these surface molecules in protozoa and fungi.http://dx.doi.org/10.1155/2011/479146 |
| spellingShingle | Marta T. Gomes Angela H. Lopes José Roberto Meyer-Fernandes Possible Roles of Ectophosphatases in Host-Parasite Interactions Journal of Parasitology Research |
| title | Possible Roles of Ectophosphatases in Host-Parasite Interactions |
| title_full | Possible Roles of Ectophosphatases in Host-Parasite Interactions |
| title_fullStr | Possible Roles of Ectophosphatases in Host-Parasite Interactions |
| title_full_unstemmed | Possible Roles of Ectophosphatases in Host-Parasite Interactions |
| title_short | Possible Roles of Ectophosphatases in Host-Parasite Interactions |
| title_sort | possible roles of ectophosphatases in host parasite interactions |
| url | http://dx.doi.org/10.1155/2011/479146 |
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