Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia
The Philadelphia (Ph1) chromosome arising from the reciprocal t(9;22) translocation is found in more than 90% of chronic myeloid leukemia (CML) patients and results in the formation of the chimeric fusion gene BCR-ABL. However, a small proportion of patients with CML have simple or complex varia...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2009/187125 |
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| Summary: | The Philadelphia (Ph1) chromosome arising from the reciprocal t(9;22)
translocation is found in more than 90% of chronic myeloid
leukemia (CML) patients and results in the formation of the
chimeric fusion gene BCR-ABL. However, a small
proportion of patients with CML have simple or complex variants of
this translocation, involving various breakpoints in addition to
9q34 and 22q11. We report five CML cases carrying variant Ph
translocations involving both chromosomes 9 and 22 as well as
chromosomes 3, 5, 7, 8, or 10. G-banding showed a reciprocal
three-way translocation involving 3q21, 5q31, 7q32, 8q24, and 10q22
bands. BCR-ABL fusion signal on der(22) was found
in all of the cases by FISH. |
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| ISSN: | 1687-9104 1687-9112 |