Food interactions with tyrosine kinase inhibitors used to treat advanced renal cell carcinoma
Renal cancer accounts for approximately 4.4% of all malignant tumors worldwide. In the case of tumors limited to the kidney, the primary method of treatment is surgery. For advanced renal cell carcinoma (RCC), one of the treatment methods is targeted therapy aimed at molecular targets via tyrosine k...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2025-03-01
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| Series: | Contemporary Oncology |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Food-interactions-with-tyrosine-kinase-inhibitors-used-to-treat-advanced-renal-cell-carcinoma,3,55705,1,1.html |
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| _version_ | 1849322110048010240 |
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| author | Agata Sałek-Zań Mirosława Püsküllüoğlu Karolina Syrek-Kaplita Tomasz Banaś |
| author_facet | Agata Sałek-Zań Mirosława Püsküllüoğlu Karolina Syrek-Kaplita Tomasz Banaś |
| author_sort | Agata Sałek-Zań |
| collection | DOAJ |
| description | Renal cancer accounts for approximately 4.4% of all malignant tumors worldwide. In the case of tumors limited to the kidney, the primary method of treatment is surgery. For advanced renal cell carcinoma (RCC), one of the treatment methods is targeted therapy aimed at molecular targets via tyrosine kinase inhibitors (TKIs). These drugs are administered orally, significantly improving the comfort of patients. However, for a drug administered in oral form to produce the intended effect in the body, it must undergo many transformations during which it interacts with various chemical compounds. These include other medications taken by the patient and those derived from food. As a result of these interactions, at each stage of the drug’s transformation, there may be interactions between that drug and these substances. Information about possible drug-drug interactions is widely available. In contrast, knowledge about drug-food interactions is a relatively new area of medical research. It has been demonstrated that these interactions can affect not only the increased toxicity of the therapy but also its effectiveness. This study reviews the possible interactions of popular food products with TKIs used in RCC treatment, at different stages of drug metabolism, and the possible mechanisms of these interactions. |
| format | Article |
| id | doaj-art-1f1273597e174cc59ed9b9e6295f7199 |
| institution | Kabale University |
| issn | 1428-2526 1897-4309 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Contemporary Oncology |
| spelling | doaj-art-1f1273597e174cc59ed9b9e6295f71992025-08-20T03:49:32ZengTermedia Publishing HouseContemporary Oncology1428-25261897-43092025-03-0129111010.5114/wo.2025.14822955705Food interactions with tyrosine kinase inhibitors used to treat advanced renal cell carcinomaAgata Sałek-ZańMirosława PüsküllüoğluKarolina Syrek-KaplitaTomasz BanaśRenal cancer accounts for approximately 4.4% of all malignant tumors worldwide. In the case of tumors limited to the kidney, the primary method of treatment is surgery. For advanced renal cell carcinoma (RCC), one of the treatment methods is targeted therapy aimed at molecular targets via tyrosine kinase inhibitors (TKIs). These drugs are administered orally, significantly improving the comfort of patients. However, for a drug administered in oral form to produce the intended effect in the body, it must undergo many transformations during which it interacts with various chemical compounds. These include other medications taken by the patient and those derived from food. As a result of these interactions, at each stage of the drug’s transformation, there may be interactions between that drug and these substances. Information about possible drug-drug interactions is widely available. In contrast, knowledge about drug-food interactions is a relatively new area of medical research. It has been demonstrated that these interactions can affect not only the increased toxicity of the therapy but also its effectiveness. This study reviews the possible interactions of popular food products with TKIs used in RCC treatment, at different stages of drug metabolism, and the possible mechanisms of these interactions.https://www.termedia.pl/Food-interactions-with-tyrosine-kinase-inhibitors-used-to-treat-advanced-renal-cell-carcinoma,3,55705,1,1.htmlrenal cancer tyrosine kinase inhibitors drug metabolism food-drug interactions |
| spellingShingle | Agata Sałek-Zań Mirosława Püsküllüoğlu Karolina Syrek-Kaplita Tomasz Banaś Food interactions with tyrosine kinase inhibitors used to treat advanced renal cell carcinoma Contemporary Oncology renal cancer tyrosine kinase inhibitors drug metabolism food-drug interactions |
| title | Food interactions with tyrosine kinase inhibitors used to treat advanced renal cell carcinoma |
| title_full | Food interactions with tyrosine kinase inhibitors used to treat advanced renal cell carcinoma |
| title_fullStr | Food interactions with tyrosine kinase inhibitors used to treat advanced renal cell carcinoma |
| title_full_unstemmed | Food interactions with tyrosine kinase inhibitors used to treat advanced renal cell carcinoma |
| title_short | Food interactions with tyrosine kinase inhibitors used to treat advanced renal cell carcinoma |
| title_sort | food interactions with tyrosine kinase inhibitors used to treat advanced renal cell carcinoma |
| topic | renal cancer tyrosine kinase inhibitors drug metabolism food-drug interactions |
| url | https://www.termedia.pl/Food-interactions-with-tyrosine-kinase-inhibitors-used-to-treat-advanced-renal-cell-carcinoma,3,55705,1,1.html |
| work_keys_str_mv | AT agatasałekzan foodinteractionswithtyrosinekinaseinhibitorsusedtotreatadvancedrenalcellcarcinoma AT mirosławapuskulluoglu foodinteractionswithtyrosinekinaseinhibitorsusedtotreatadvancedrenalcellcarcinoma AT karolinasyrekkaplita foodinteractionswithtyrosinekinaseinhibitorsusedtotreatadvancedrenalcellcarcinoma AT tomaszbanas foodinteractionswithtyrosinekinaseinhibitorsusedtotreatadvancedrenalcellcarcinoma |