Predictive and prognostic values of serum C1q/tumor necrosis factor-related protein 9 for first-ever ischemic stroke
BackgroundThe C1q/Tumor Necrosis Factor-related Protein 9 (CTRP9) is a relatively novel adipokine having showed protection on cerebrovascular system. However, its clinical values have not been well established. This work is to evaluate CTRP9 as predictors of onset risk and outcome of ischemic stroke...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1526853/full |
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| author | Yan-Qing Zhang Yan-Qing Zhang Hai-Feng Zhang Xiao-Gang Liu Rong Li |
| author_facet | Yan-Qing Zhang Yan-Qing Zhang Hai-Feng Zhang Xiao-Gang Liu Rong Li |
| author_sort | Yan-Qing Zhang |
| collection | DOAJ |
| description | BackgroundThe C1q/Tumor Necrosis Factor-related Protein 9 (CTRP9) is a relatively novel adipokine having showed protection on cerebrovascular system. However, its clinical values have not been well established. This work is to evaluate CTRP9 as predictors of onset risk and outcome of ischemic stroke.MethodsOne thousand one hundred and twenty-three patients undergoing first-ever ischemic stroke and 835 controls were enrolled. Serum CTRP9 was determined within 24 h after the onset. One thousand and twenty-six patients were successfully followed up for all-cause and cardiovascular deaths. Stepwise regression was conducted to screen the independent factors of stroke onset in the whole sample and mortality in the patient subgroup. Survival curves were plotted to evaluate the effect of baseline serum CTRP9 on 3-year all-cause and cardiovascular mortalities of stroke patients.ResultsAt baseline, prevalence of first-ever onset of ischemic stroke in high CTRP9 group was significantly lower than that in low CTRP9 group (p < 0.05) in non-hyperlipidemic subjects. Accumulative all-cause and cardiovascular mortality of patients with high baseline CTRP9 was significantly lower for the first year post stroke onset (p < 0.05). Baseline low CTRP9 was one of the independent risk factors of 3-year all-cause mortality (p < 0.05) of ischemic stroke patients.ConclusionHigh serum CTRP9 exerted protection against first-ever onset of ischemic stroke in non-hyperlipidemic subjects, and also protected general stroke patients against all-cause and cardiovascular mortality at least 1 year post stroke onset. Our findings in this study may pinpoint both the predictive and prognostic values of CTRP9 as a promising biomarker. |
| format | Article |
| id | doaj-art-1f0d7b43924049ac989d57147bcd9ee0 |
| institution | DOAJ |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-1f0d7b43924049ac989d57147bcd9ee02025-08-20T02:57:56ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-03-011610.3389/fneur.2025.15268531526853Predictive and prognostic values of serum C1q/tumor necrosis factor-related protein 9 for first-ever ischemic strokeYan-Qing Zhang0Yan-Qing Zhang1Hai-Feng Zhang2Xiao-Gang Liu3Rong Li4Department of Anesthesiology, University Town Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Anesthesiology, The First Hospital, Shanxi Medical University, Taiyuan, ChinaDepartment of Teaching and Experiment Center, Air Force Military Medical University, Xi’an, ChinaThe Key Laboratory of Biomedical Information Engineering of Ministry of Education of China, School of Life Science and Technology, Xi’an Jiaotong University, Xi'an, ChinaDepartment of Geriatrics, Xijing Hospital, The Fourth Military Medical University, Xi’an, ChinaBackgroundThe C1q/Tumor Necrosis Factor-related Protein 9 (CTRP9) is a relatively novel adipokine having showed protection on cerebrovascular system. However, its clinical values have not been well established. This work is to evaluate CTRP9 as predictors of onset risk and outcome of ischemic stroke.MethodsOne thousand one hundred and twenty-three patients undergoing first-ever ischemic stroke and 835 controls were enrolled. Serum CTRP9 was determined within 24 h after the onset. One thousand and twenty-six patients were successfully followed up for all-cause and cardiovascular deaths. Stepwise regression was conducted to screen the independent factors of stroke onset in the whole sample and mortality in the patient subgroup. Survival curves were plotted to evaluate the effect of baseline serum CTRP9 on 3-year all-cause and cardiovascular mortalities of stroke patients.ResultsAt baseline, prevalence of first-ever onset of ischemic stroke in high CTRP9 group was significantly lower than that in low CTRP9 group (p < 0.05) in non-hyperlipidemic subjects. Accumulative all-cause and cardiovascular mortality of patients with high baseline CTRP9 was significantly lower for the first year post stroke onset (p < 0.05). Baseline low CTRP9 was one of the independent risk factors of 3-year all-cause mortality (p < 0.05) of ischemic stroke patients.ConclusionHigh serum CTRP9 exerted protection against first-ever onset of ischemic stroke in non-hyperlipidemic subjects, and also protected general stroke patients against all-cause and cardiovascular mortality at least 1 year post stroke onset. Our findings in this study may pinpoint both the predictive and prognostic values of CTRP9 as a promising biomarker.https://www.frontiersin.org/articles/10.3389/fneur.2025.1526853/fullischemic strokeCTRP9adiponectinprognosismortality |
| spellingShingle | Yan-Qing Zhang Yan-Qing Zhang Hai-Feng Zhang Xiao-Gang Liu Rong Li Predictive and prognostic values of serum C1q/tumor necrosis factor-related protein 9 for first-ever ischemic stroke Frontiers in Neurology ischemic stroke CTRP9 adiponectin prognosis mortality |
| title | Predictive and prognostic values of serum C1q/tumor necrosis factor-related protein 9 for first-ever ischemic stroke |
| title_full | Predictive and prognostic values of serum C1q/tumor necrosis factor-related protein 9 for first-ever ischemic stroke |
| title_fullStr | Predictive and prognostic values of serum C1q/tumor necrosis factor-related protein 9 for first-ever ischemic stroke |
| title_full_unstemmed | Predictive and prognostic values of serum C1q/tumor necrosis factor-related protein 9 for first-ever ischemic stroke |
| title_short | Predictive and prognostic values of serum C1q/tumor necrosis factor-related protein 9 for first-ever ischemic stroke |
| title_sort | predictive and prognostic values of serum c1q tumor necrosis factor related protein 9 for first ever ischemic stroke |
| topic | ischemic stroke CTRP9 adiponectin prognosis mortality |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1526853/full |
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