The Effects of Induction and Treatment of Intracranial Hypertension on Cerebral Autoregulation: An Experimental Study
Background. This study aimed to analyse cerebral autoregulation (CA) during induction and treatment of intracranial hypertension (ICH) in an experimental model. Materials and Methods. Landrace and Duroc piglets were divided into mild and severe ICH groups. Four or seven millilitres of saline solutio...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2018/7053932 |
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| author | Marcelo de Lima Oliveira Angela Macedo Salinet Ricardo de Carvalho Nogueira Alessandro Rodrigo Belon Wellingson Silva Paiva Brasil Chian Ping Jeng Manoel Jacobsen Teixeira Edson Bor-Seng-Shu |
| author_facet | Marcelo de Lima Oliveira Angela Macedo Salinet Ricardo de Carvalho Nogueira Alessandro Rodrigo Belon Wellingson Silva Paiva Brasil Chian Ping Jeng Manoel Jacobsen Teixeira Edson Bor-Seng-Shu |
| author_sort | Marcelo de Lima Oliveira |
| collection | DOAJ |
| description | Background. This study aimed to analyse cerebral autoregulation (CA) during induction and treatment of intracranial hypertension (ICH) in an experimental model. Materials and Methods. Landrace and Duroc piglets were divided into mild and severe ICH groups. Four or seven millilitres of saline solution was infused into paediatric bladder catheter inserted in the parietal lobe (balloon inflation). After 1.5 h, a 3% saline solution was infused via venous catheter, and 30 min later, the bladder catheter balloon was deflated (surgery). The cerebral static autoregulation (sCA) index was evaluated using cerebral blood flow velocities (CBFV) obtained with Doppler ultrasound. Results. Balloon inflation increased ICP in both groups. The severe ICH group showed significantly lower sCA index values (p=0.001, ANOVA) after balloon inflation (ICH induction) and a higher sCA index after saline injection (p=0.02) and after surgery (p=0.04). ICP and the sCA index were inversely correlated (r=−0.68 and p<0.05). CPP and the sCA index were directly correlated (r=0.74 and p<0.05). Conclusion. ICH was associated with local balloon expansion, which triggered CA impairment, particularly in the severe ICH group. Moreover, ICP-reducing treatments were associated with improved CA in subjects with severe ICH. |
| format | Article |
| id | doaj-art-1f0ae0ffe3674a6fa424989194b5ead5 |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-1f0ae0ffe3674a6fa424989194b5ead52025-02-03T05:46:41ZengWileyNeurology Research International2090-18522090-18602018-01-01201810.1155/2018/70539327053932The Effects of Induction and Treatment of Intracranial Hypertension on Cerebral Autoregulation: An Experimental StudyMarcelo de Lima Oliveira0Angela Macedo Salinet1Ricardo de Carvalho Nogueira2Alessandro Rodrigo Belon3Wellingson Silva Paiva4Brasil Chian Ping Jeng5Manoel Jacobsen Teixeira6Edson Bor-Seng-Shu7Division of Neurosurgery, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, BrazilDivision of Neurosurgery, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, BrazilDivision of Neurosurgery, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, BrazilDivision of Neurosurgery, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, BrazilDivision of Neurosurgery, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, BrazilDivision of Neurosurgery, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, BrazilDivision of Neurosurgery, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, BrazilDivision of Neurosurgery, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, BrazilBackground. This study aimed to analyse cerebral autoregulation (CA) during induction and treatment of intracranial hypertension (ICH) in an experimental model. Materials and Methods. Landrace and Duroc piglets were divided into mild and severe ICH groups. Four or seven millilitres of saline solution was infused into paediatric bladder catheter inserted in the parietal lobe (balloon inflation). After 1.5 h, a 3% saline solution was infused via venous catheter, and 30 min later, the bladder catheter balloon was deflated (surgery). The cerebral static autoregulation (sCA) index was evaluated using cerebral blood flow velocities (CBFV) obtained with Doppler ultrasound. Results. Balloon inflation increased ICP in both groups. The severe ICH group showed significantly lower sCA index values (p=0.001, ANOVA) after balloon inflation (ICH induction) and a higher sCA index after saline injection (p=0.02) and after surgery (p=0.04). ICP and the sCA index were inversely correlated (r=−0.68 and p<0.05). CPP and the sCA index were directly correlated (r=0.74 and p<0.05). Conclusion. ICH was associated with local balloon expansion, which triggered CA impairment, particularly in the severe ICH group. Moreover, ICP-reducing treatments were associated with improved CA in subjects with severe ICH.http://dx.doi.org/10.1155/2018/7053932 |
| spellingShingle | Marcelo de Lima Oliveira Angela Macedo Salinet Ricardo de Carvalho Nogueira Alessandro Rodrigo Belon Wellingson Silva Paiva Brasil Chian Ping Jeng Manoel Jacobsen Teixeira Edson Bor-Seng-Shu The Effects of Induction and Treatment of Intracranial Hypertension on Cerebral Autoregulation: An Experimental Study Neurology Research International |
| title | The Effects of Induction and Treatment of Intracranial Hypertension on Cerebral Autoregulation: An Experimental Study |
| title_full | The Effects of Induction and Treatment of Intracranial Hypertension on Cerebral Autoregulation: An Experimental Study |
| title_fullStr | The Effects of Induction and Treatment of Intracranial Hypertension on Cerebral Autoregulation: An Experimental Study |
| title_full_unstemmed | The Effects of Induction and Treatment of Intracranial Hypertension on Cerebral Autoregulation: An Experimental Study |
| title_short | The Effects of Induction and Treatment of Intracranial Hypertension on Cerebral Autoregulation: An Experimental Study |
| title_sort | effects of induction and treatment of intracranial hypertension on cerebral autoregulation an experimental study |
| url | http://dx.doi.org/10.1155/2018/7053932 |
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