HIV risk perception, trust and PrEP adherence among participants in an HIV prevention trial: a qualitative longitudinal study, South Africa

HIV risk perception, trust and PrEP adherence among participants in an HIV prevention trial: a qualitative longitudinal study, South Africa

Introduction Ensuring the effectiveness of HIV prevention and treatment methods requires high levels of adherence. Studies have recognised the significance of trust in shaping HIV risk perception.Aim In this qualitative analysis, our aim was to explore risk perceptions and understand how individuals...

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Main Authors: Giuseppe Pantaleo, Glenda Gray, Pontiano Kaleebu, Said Aboud, David Dunn, Merlin Robb, Janet Seeley, Sheena McCormack, Julie Fox, Jim Rooney, Tom Miller, Agricola Joachim, Ilesh Jani, Mary Amondi, Peter Hughes, Sarah Joseph, Eugene Ruzagira, Vincent Basajja, Jonathan Weber, Cherry Kingsley, Eligius Lyamuya, Lucas Maganga, Doreen Pamba, Edna Viegas, Charlotta Nilsson, Arne Kroidl, Angela Crook, Anne Gumbe, Phindile Khanyile, Jennifer Serwanga, Carter Lee, Kundai Chinyenze, Song Ding, Muhammad Bakari, Neetha Morar, Ayoub Kakande, Tumaini Nagu, Henry Bern, Sylvia Kusemererwa, Patricia Munseri, Lwitiho Sudi, Jorge Ribeiro, Igor Capitine, Diana Faini, Edna Nhacule, Kubashni Woeber, Yolanda Manganhe, Abisai Kisinda, Wiston William, Rujeko Samanthia Chimukuche, Londiwe Shandu, Silindile Zulu, Nishanta Singh, Zakir Gaffoor, Rachel Kawuma, Thandiwe Sithole, Samantha Siva, Eldinah Hwengwere, Rujeko Samanthia Chidawanyika, Nteboheleng Mahapa, Isabel Remane, Odete Bule, Patricia Ramgi, Raquel Chissumba, Eduardo Namalango, Carmelia Massingue, Emmanuel Kapesa, Elizabeth Danstan, Marco Missanga, Amani Kway, Lilian Njovu, Revocatus Kunambi, Frank Msafiri, Edith Tarimo, Deus Buma, Freddie Mukasa Kibengo, Christian Hansen Holmes, Sheila Kansiime, Sylvia Masawi, Tobias Vudriko, Shamim Nabukenya, Gertrude Mutonyi, Rita Nakiboneka, Susan Mugaba, Aminata Sy, Liz Brodnicki, Claire Wenden, Jacqueline Musau, Mabela Matsoso, Paramesh Chetty, Gustavo Doncel, Allison Matthews
Format: Article
Language:English
Published: BMJ Publishing Group 2025-04-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/4/e086742.full
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Summary:Introduction Ensuring the effectiveness of HIV prevention and treatment methods requires high levels of adherence. Studies have recognised the significance of trust in shaping HIV risk perception.Aim In this qualitative analysis, our aim was to explore risk perceptions and understand how individuals assess and respond to HIV risks, as well as their uptake and adherence to oral pre-exposure prophylaxis (PrEP).Setting The study was based on the setting of an HIV prevention trial conducted in South Africa.Methods Thirty individuals, 9% of the total clinical trial participants, enrolled in the clinical trial were purposively selected and interviewed at three time points within the trial during the follow-up phase. Data analysis was conducted using the Trust, Confidence and Cooperation framework that included constructs of trust, confidence and cooperation.Results The findings show that the ongoing participation in the clinical trial played a significant role in influencing participants’ decision to continue PrEP as HIV prevention. This decision was grounded in their trust that PrEP would effectively reduce their vulnerability to HIV and infection.Conclusion Clear and consistent health-promoting initiatives enhance participants’ self-awareness of HIV risks and promote understanding (uptake) and effectiveness of HIV prevention methods.Trial registration number NCT04066881.
ISSN:2044-6055

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