Association of depressive symptoms with the progression of carotid intima–media thickness in a community-based cohort in Beijing, China
Objectives To determine the relationship between depressive symptoms and progression of carotid intima–media thickness (cIMT) in a Beijing community-based population.Design Prospective cohort study between 2014 and 2018.Setting Dwellers without cardiovascular disease, hypertension or diabetes from a...
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BMJ Publishing Group
2021-08-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/11/8/e050254.full |
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| author | Bo Liu Ying Yang Pengfei Sun Jia Jia Mengyuan Liu Fangfang Fan Zhongli Wu Yimeng Jiang Danmei He |
| author_facet | Bo Liu Ying Yang Pengfei Sun Jia Jia Mengyuan Liu Fangfang Fan Zhongli Wu Yimeng Jiang Danmei He |
| author_sort | Bo Liu |
| collection | DOAJ |
| description | Objectives To determine the relationship between depressive symptoms and progression of carotid intima–media thickness (cIMT) in a Beijing community-based population.Design Prospective cohort study between 2014 and 2018.Setting Dwellers without cardiovascular disease, hypertension or diabetes from a Beijing community.Participants 3849 Chinese community-dwelling individuals who underwent baseline screening for depressive symptoms were invited to participate in the study in 2014 and follow-up visit in 2018. Among them, 2124 participants completed carotid ultrasound examination both at baseline and a follow-up visit. After further excluding patients with a history of stroke, myocardial infarction or lower extremity arterial stenosis and those with a diagnosis of hypertension or diabetes and ankle–brachial index ≤0.9 at baseline, 1011 eligible participants were finally included.Primary outcome measure The rate of mean cIMT change.Results Over a median follow-up period of 4.40 years, the overall rate of mean cIMT change was 2.23% (−5.64% to 9.51%). After adjustment for 13 covariates, there was an increase of 2.36% (β=2.36, 95% CI: 0.37 to 4.36, p=0.020) for the rates of mean cIMT change in the depressive group compared with the control group. Furthermore, this association was modified by drinking status (β=3.22, 95% CI: 1.25 to 5.19, P-interaction=0.006).Conclusion Depressive symptoms were independently associated with progression of mean cIMT in a community-based cohort in Beijing, China. Furthermore, this relationship was modified by drinking status. |
| format | Article |
| id | doaj-art-1f08673de99d4282b5f32fd91bded745 |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2021-08-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open |
| spelling | doaj-art-1f08673de99d4282b5f32fd91bded7452025-08-20T02:21:02ZengBMJ Publishing GroupBMJ Open2044-60552021-08-0111810.1136/bmjopen-2021-050254Association of depressive symptoms with the progression of carotid intima–media thickness in a community-based cohort in Beijing, ChinaBo Liu0Ying Yang1Pengfei Sun2Jia Jia3Mengyuan Liu4Fangfang Fan5Zhongli Wu6Yimeng Jiang7Danmei He8Beijing Institute of Otolaryngology, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaInstitute of Cardiovascular Disease, Peking University First Hospital, Beijing, ChinaDepartment of Hepatobiliary Surgery, Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaDepartment of cardiology, Peking University First Hospital, Beijing, ChinaInstitute of Cardiovascular Disease, Peking University First Hospital, Beijing, ChinaDepartment of Cardiology, Peking University First Hospital, Beijing, ChinaDepartment of cardiology, Peking University First Hospital, Beijing, ChinaDepartment of cardiology, Peking University First Hospital, Beijing, ChinaDepartment of cardiology, Peking University First Hospital, Beijing, ChinaObjectives To determine the relationship between depressive symptoms and progression of carotid intima–media thickness (cIMT) in a Beijing community-based population.Design Prospective cohort study between 2014 and 2018.Setting Dwellers without cardiovascular disease, hypertension or diabetes from a Beijing community.Participants 3849 Chinese community-dwelling individuals who underwent baseline screening for depressive symptoms were invited to participate in the study in 2014 and follow-up visit in 2018. Among them, 2124 participants completed carotid ultrasound examination both at baseline and a follow-up visit. After further excluding patients with a history of stroke, myocardial infarction or lower extremity arterial stenosis and those with a diagnosis of hypertension or diabetes and ankle–brachial index ≤0.9 at baseline, 1011 eligible participants were finally included.Primary outcome measure The rate of mean cIMT change.Results Over a median follow-up period of 4.40 years, the overall rate of mean cIMT change was 2.23% (−5.64% to 9.51%). After adjustment for 13 covariates, there was an increase of 2.36% (β=2.36, 95% CI: 0.37 to 4.36, p=0.020) for the rates of mean cIMT change in the depressive group compared with the control group. Furthermore, this association was modified by drinking status (β=3.22, 95% CI: 1.25 to 5.19, P-interaction=0.006).Conclusion Depressive symptoms were independently associated with progression of mean cIMT in a community-based cohort in Beijing, China. Furthermore, this relationship was modified by drinking status.https://bmjopen.bmj.com/content/11/8/e050254.full |
| spellingShingle | Bo Liu Ying Yang Pengfei Sun Jia Jia Mengyuan Liu Fangfang Fan Zhongli Wu Yimeng Jiang Danmei He Association of depressive symptoms with the progression of carotid intima–media thickness in a community-based cohort in Beijing, China BMJ Open |
| title | Association of depressive symptoms with the progression of carotid intima–media thickness in a community-based cohort in Beijing, China |
| title_full | Association of depressive symptoms with the progression of carotid intima–media thickness in a community-based cohort in Beijing, China |
| title_fullStr | Association of depressive symptoms with the progression of carotid intima–media thickness in a community-based cohort in Beijing, China |
| title_full_unstemmed | Association of depressive symptoms with the progression of carotid intima–media thickness in a community-based cohort in Beijing, China |
| title_short | Association of depressive symptoms with the progression of carotid intima–media thickness in a community-based cohort in Beijing, China |
| title_sort | association of depressive symptoms with the progression of carotid intima media thickness in a community based cohort in beijing china |
| url | https://bmjopen.bmj.com/content/11/8/e050254.full |
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