Personalized Contrast Agent Volumes in Abdominal CT: Bridging Theory with Practice
Objectives: to determine (1) a target Hounsfield unit (HU) for portal venous phase iodinated contrast media enhanced abdominal CT scans, (2) an equation for a personalized total contrast agent volume, and (3) the best/most appropriate time between injection and plateau/peak in HU enhancement. Materi...
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Ubiquity Press
2025-06-01
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| Series: | Journal of the Belgian Society of Radiology |
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| Online Access: | https://account.jbsr.be/index.php/up-j-jbsr/article/view/3906 |
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| author | Walter Coudyzer Lesley Cockmartin Bram Miseur Tim Busselot Didier Bielen Dirk Vanbeckevoort Raymond Oyen Hilde Bosmans |
| author_facet | Walter Coudyzer Lesley Cockmartin Bram Miseur Tim Busselot Didier Bielen Dirk Vanbeckevoort Raymond Oyen Hilde Bosmans |
| author_sort | Walter Coudyzer |
| collection | DOAJ |
| description | Objectives: to determine (1) a target Hounsfield unit (HU) for portal venous phase iodinated contrast media enhanced abdominal CT scans, (2) an equation for a personalized total contrast agent volume, and (3) the best/most appropriate time between injection and plateau/peak in HU enhancement. Material and methods: from an original dataset of 5,000 cases, a weight representative subset of 370 cases was sampled for detailed HU measurements. An additional 90 cases were used for visual grading to define the minimal HU required for diagnostic quality, which led to the proposed target HU. This study uses the fact that in a first approach, the injected contrast agent volume and HU correlate linearly. Based on the injected contrast agent volumes and HU measurements in the patient scans, it was then calculated which (ideal) volume would have reached the target value. The ideal volumes and patient data (weight, height, heart rate, age, and gender) were correlated by means of a regression analysis, to determine a new patient-specific contrast volume calculation equation. The best scan delay time was derived from the start of the injection to the HU enhancement plateau/peak evaluated from manually triggered venous phase scans. Results: The target HU value was 125. This can be achieved with a personalized contrast agent volume (ml), equal to − 108.5 + ∗ weight(kg) + 0.40 ∗ heart rate(bpm) + 0.61 ∗ height(cm). The time delay between injection and HU plateau/peak was found to be, on average, 102 s. Conclusion: this study proposes a comprehensive protocol for contrast enhanced venous phase scans, including a target HU, a personalized contrast volume, and a scan delay. |
| format | Article |
| id | doaj-art-1f0738b5e0d5464f9bc66571efaab4aa |
| institution | Kabale University |
| issn | 2514-8281 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Ubiquity Press |
| record_format | Article |
| series | Journal of the Belgian Society of Radiology |
| spelling | doaj-art-1f0738b5e0d5464f9bc66571efaab4aa2025-08-20T03:24:56ZengUbiquity PressJournal of the Belgian Society of Radiology2514-82812025-06-011091212110.5334/jbsr.39063902Personalized Contrast Agent Volumes in Abdominal CT: Bridging Theory with PracticeWalter Coudyzer0Lesley Cockmartin1Bram Miseur2Tim Busselot3Didier Bielen4Dirk Vanbeckevoort5Raymond Oyen6Hilde Bosmans7Department of Radiology, University Hospitals KU Leuven, Herestraat 49, 3000 LeuvenDepartment of Radiology, University Hospitals KU Leuven, Herestraat 49, 3000 LeuvenDepartment of Radiology, University Hospitals KU Leuven, Herestraat 49, 3000 LeuvenDepartment of Radiology, University Hospitals KU Leuven, Herestraat 49, 3000 LeuvenDepartment of Radiology, University Hospitals KU Leuven, Herestraat 49, 3000 LeuvenDepartment of Radiology, University Hospitals KU Leuven, Herestraat 49, 3000 LeuvenDepartment of Radiology, University Hospitals KU Leuven, Herestraat 49, 3000 LeuvenDepartment of Radiology, University Hospitals KU Leuven, Herestraat 49, 3000 LeuvenObjectives: to determine (1) a target Hounsfield unit (HU) for portal venous phase iodinated contrast media enhanced abdominal CT scans, (2) an equation for a personalized total contrast agent volume, and (3) the best/most appropriate time between injection and plateau/peak in HU enhancement. Material and methods: from an original dataset of 5,000 cases, a weight representative subset of 370 cases was sampled for detailed HU measurements. An additional 90 cases were used for visual grading to define the minimal HU required for diagnostic quality, which led to the proposed target HU. This study uses the fact that in a first approach, the injected contrast agent volume and HU correlate linearly. Based on the injected contrast agent volumes and HU measurements in the patient scans, it was then calculated which (ideal) volume would have reached the target value. The ideal volumes and patient data (weight, height, heart rate, age, and gender) were correlated by means of a regression analysis, to determine a new patient-specific contrast volume calculation equation. The best scan delay time was derived from the start of the injection to the HU enhancement plateau/peak evaluated from manually triggered venous phase scans. Results: The target HU value was 125. This can be achieved with a personalized contrast agent volume (ml), equal to − 108.5 + ∗ weight(kg) + 0.40 ∗ heart rate(bpm) + 0.61 ∗ height(cm). The time delay between injection and HU plateau/peak was found to be, on average, 102 s. Conclusion: this study proposes a comprehensive protocol for contrast enhanced venous phase scans, including a target HU, a personalized contrast volume, and a scan delay.https://account.jbsr.be/index.php/up-j-jbsr/article/view/3906abdominal ct examinationspatient tailored contrast injectionsiodinated contrast agentscontrast agent scan delayscontrast volume calculationhu target values |
| spellingShingle | Walter Coudyzer Lesley Cockmartin Bram Miseur Tim Busselot Didier Bielen Dirk Vanbeckevoort Raymond Oyen Hilde Bosmans Personalized Contrast Agent Volumes in Abdominal CT: Bridging Theory with Practice Journal of the Belgian Society of Radiology abdominal ct examinations patient tailored contrast injections iodinated contrast agents contrast agent scan delays contrast volume calculation hu target values |
| title | Personalized Contrast Agent Volumes in Abdominal CT: Bridging Theory with Practice |
| title_full | Personalized Contrast Agent Volumes in Abdominal CT: Bridging Theory with Practice |
| title_fullStr | Personalized Contrast Agent Volumes in Abdominal CT: Bridging Theory with Practice |
| title_full_unstemmed | Personalized Contrast Agent Volumes in Abdominal CT: Bridging Theory with Practice |
| title_short | Personalized Contrast Agent Volumes in Abdominal CT: Bridging Theory with Practice |
| title_sort | personalized contrast agent volumes in abdominal ct bridging theory with practice |
| topic | abdominal ct examinations patient tailored contrast injections iodinated contrast agents contrast agent scan delays contrast volume calculation hu target values |
| url | https://account.jbsr.be/index.php/up-j-jbsr/article/view/3906 |
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