The GPR4 antagonist NE-52-QQ57 increases survival, mitigates the hyperinflammatory response and reduces viral load in SARS-CoV-2-infected K18-hACE2 transgenic mice

The GPR4 antagonist NE-52-QQ57 increases survival, mitigates the hyperinflammatory response and reduces viral load in SARS-CoV-2-infected K18-hACE2 transgenic mice

COVID-19 (Coronavirus disease 19) is caused by infection with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) in the respiratory system and other organ systems. Tissue injuries resulting from viral infection and host hyperinflammatory responses may lead to moderate to severe pneumonia,...

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Bibliographic Details
Main Authors: Xin-Jun Wu, Karen A. Oppelt, Ming Fan, Mona A. Marie, Madison M. Swyers, Ashley J. Williams, Isabelle M. Lemasson, Rachel L. Roper, Paul Bolin, Li V. Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
GPR4 antagonist
SARS-CoV-2
COVID-19
mouse model
anti-inflammation
antiviral
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1549296/full
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