Effects of radiofrequency on the healing of skin wounds in rats: analysis using digital planigraphy and histological evaluation
INTRODUCTION: Given the extensive use of plastic surgery and the search for better aesthetic and functional results, it is necessary to research ways to improve healing and scarring. The objective is to evaluate the effects of three radiofrequency (RF) sessions in healing the skin of mice....
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Thieme Revinter Publicações Ltda.
2016-12-01
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| Series: | Revista Brasileira de Cirurgia Plástica |
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| Online Access: | http://www.rbcp.org.br/export-pdf/1796/en_v31n4a18.pdf |
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| author | Ana Maria Cardoso Cepeda Antonio Carlos Campos Gilian Fernanda Dias Erzinger Priscila Balbinot |
| author_facet | Ana Maria Cardoso Cepeda Antonio Carlos Campos Gilian Fernanda Dias Erzinger Priscila Balbinot |
| author_sort | Ana Maria Cardoso Cepeda |
| collection | DOAJ |
| description | INTRODUCTION: Given the extensive use of plastic surgery and the search for better aesthetic and functional results, it is necessary to research ways to improve healing and scarring. The objective is to evaluate the effects of three radiofrequency (RF) sessions in healing the skin of mice.
METHODS: Forty-eight rats were divided into four groups by day of sacrifice and treatment (RF group: RG; control group: CG). Dissection of the excisional wound of 2 cm x 2 cm (4 cm²) was performed and a 6-mm punch was used to hold two excisional wounds 0.6 cm in diameter. After 24 h, radiofrequency was performed using Spectra® directly on the wound in the dorsal region for 7 minutes at 38ºC. This was repeated three times on alternate days. For the control group, the radiofrequency protocol was performed with the device switched off.
RESULTS: A larger area of the square wound was measured on postoperative day three in RG (RG7: 3.3 cm² ± 0.7 cm² vs. CG7: 2.4 cm² ± 0.4 cm²; p = 0.009). On day 14, the square wound in RG was greater than in CG (RG14: 1.9 cm² ± 0.5 cm² vs. CG14: 1.0 cm² ± 0.3 cm²; p = 0.001). There was a 90% closure of wounds in CG14. In RG14, 60% of the wounds were re-epithelized while 40% remained ulcerated. In CG7, 70% of the remaining wounds were ulcerated and 30% were re-epithelized. In RG7, 8% were re-epithelized and 92% remained ulcerated.
CONCLUSION: Radiofrequency has a negative influence on the healing process, as indicated by mice that received radiofrequency having a persistent ulcerated wound. |
| format | Article |
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| institution | Kabale University |
| issn | 1983-5175 2177-1235 |
| language | English |
| publishDate | 2016-12-01 |
| publisher | Thieme Revinter Publicações Ltda. |
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| series | Revista Brasileira de Cirurgia Plástica |
| spelling | doaj-art-1f03e86b5bb04cc8a26087c3fea9bf312025-08-20T03:58:08ZengThieme Revinter Publicações Ltda.Revista Brasileira de Cirurgia Plástica1983-51752177-12352016-12-01310455456010.5935/2177-1235.2016RBCP0091Effects of radiofrequency on the healing of skin wounds in rats: analysis using digital planigraphy and histological evaluationAna Maria Cardoso Cepeda0Antonio Carlos Campos1Gilian Fernanda Dias Erzinger2Priscila Balbinot3Universidade Federal do Paraná, Curitiba, PR, BrazilUniversidade Federal do Paraná, Curitiba, PR, BrazilUniversidade Federal do Paraná, Curitiba, PR, BrazilUniversidade Federal do Paraná, Curitiba, PR, BrazilINTRODUCTION: Given the extensive use of plastic surgery and the search for better aesthetic and functional results, it is necessary to research ways to improve healing and scarring. The objective is to evaluate the effects of three radiofrequency (RF) sessions in healing the skin of mice. METHODS: Forty-eight rats were divided into four groups by day of sacrifice and treatment (RF group: RG; control group: CG). Dissection of the excisional wound of 2 cm x 2 cm (4 cm²) was performed and a 6-mm punch was used to hold two excisional wounds 0.6 cm in diameter. After 24 h, radiofrequency was performed using Spectra® directly on the wound in the dorsal region for 7 minutes at 38ºC. This was repeated three times on alternate days. For the control group, the radiofrequency protocol was performed with the device switched off. RESULTS: A larger area of the square wound was measured on postoperative day three in RG (RG7: 3.3 cm² ± 0.7 cm² vs. CG7: 2.4 cm² ± 0.4 cm²; p = 0.009). On day 14, the square wound in RG was greater than in CG (RG14: 1.9 cm² ± 0.5 cm² vs. CG14: 1.0 cm² ± 0.3 cm²; p = 0.001). There was a 90% closure of wounds in CG14. In RG14, 60% of the wounds were re-epithelized while 40% remained ulcerated. In CG7, 70% of the remaining wounds were ulcerated and 30% were re-epithelized. In RG7, 8% were re-epithelized and 92% remained ulcerated. CONCLUSION: Radiofrequency has a negative influence on the healing process, as indicated by mice that received radiofrequency having a persistent ulcerated wound.http://www.rbcp.org.br/export-pdf/1796/en_v31n4a18.pdfhealingscarfibroblastsre-epithelialization |
| spellingShingle | Ana Maria Cardoso Cepeda Antonio Carlos Campos Gilian Fernanda Dias Erzinger Priscila Balbinot Effects of radiofrequency on the healing of skin wounds in rats: analysis using digital planigraphy and histological evaluation Revista Brasileira de Cirurgia Plástica healing scar fibroblasts re-epithelialization |
| title | Effects of radiofrequency on the healing of skin wounds in rats: analysis using digital planigraphy and histological evaluation |
| title_full | Effects of radiofrequency on the healing of skin wounds in rats: analysis using digital planigraphy and histological evaluation |
| title_fullStr | Effects of radiofrequency on the healing of skin wounds in rats: analysis using digital planigraphy and histological evaluation |
| title_full_unstemmed | Effects of radiofrequency on the healing of skin wounds in rats: analysis using digital planigraphy and histological evaluation |
| title_short | Effects of radiofrequency on the healing of skin wounds in rats: analysis using digital planigraphy and histological evaluation |
| title_sort | effects of radiofrequency on the healing of skin wounds in rats analysis using digital planigraphy and histological evaluation |
| topic | healing scar fibroblasts re-epithelialization |
| url | http://www.rbcp.org.br/export-pdf/1796/en_v31n4a18.pdf |
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