Breaking the siege of hypoxia and lactate: carrier-free flexible dual-enzyme protein vesicle to ignite photodynamic-immune storm in head and neck squamous cell carcinoma

Breaking the siege of hypoxia and lactate: carrier-free flexible dual-enzyme protein vesicle to ignite photodynamic-immune storm in head and neck squamous cell carcinoma

Photodynamic therapy (PDT) efficacy in head and neck squamous cell carcinoma (HNSCC) is hindered by hypoxia and lactate accumulation in tumor microenvironment (TME), which suppress reactive oxygen species (ROS) generation and immune activation. To address this, we developed a carrier-free flexible d...

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Bibliographic Details
Main Authors: Yan Zhou, Xiaoquan Xu, Ziyue Zu, Shangyu Lu, Wei Lu, Xi Luo, Nan Zhong, Yang Liu, Zhaogang Teng, Shouju Wang, Feiyun Wu
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Materials Today Bio
Subjects:
Head and neck squamous cell carcinoma
Hypoxia
Lactic acid
Protein vesicle
Photodynamic therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425006520
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