COX-2 Gene Promoter Polymorphism and Coronary Artery Disease in Middle-Aged Men: The Helsinki Sudden Death Study
Cyclooxygenase (COX) catalyzes formation of prostaglandins that contribute to the inflammation in atherosclerosis. Our objective was to study whether the functional C variant of the −765G→C polymorphism in the human COX-2 gene associates with the severity of coronary atherosclerosis measured at the...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2008/289453 |
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| author | Kati H. Huuskonen Tarja A. Kunnas Minna M. Tanner Jussi Mikkelsson Erkki Ilveskoski Pekka J. Karhunen Seppo T. Nikkari |
| author_facet | Kati H. Huuskonen Tarja A. Kunnas Minna M. Tanner Jussi Mikkelsson Erkki Ilveskoski Pekka J. Karhunen Seppo T. Nikkari |
| author_sort | Kati H. Huuskonen |
| collection | DOAJ |
| description | Cyclooxygenase (COX) catalyzes formation of prostaglandins that contribute to the inflammation in atherosclerosis. Our objective was to study whether the functional C variant of the −765G→C polymorphism in the human COX-2 gene associates with the severity of coronary atherosclerosis measured at the coronary artery level. The Helsinki sudden death study autopsy material (n = 300) comprised of Finnish men who died suddenly. The area of atherosclerotic lesions in the coronary arteries was quantitated, and coronary narrowing was measured. The occurrence of myocardial infarction (MI) was assessed. Genotyping was by restriction endonuclease analysis. Men carrying the minor C allele had larger areas of complicated lesions (P = .024) and a higher number of coronary arteries that had over 50% stenosis (P = .036) compared to men representing the common GG genotype. The COX-2 polymorphism was not associated with MI. Our data suggest that COX-2 may be involved in plaque growth. |
| format | Article |
| id | doaj-art-1f007c155a48414ebced52032baf540a |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1f007c155a48414ebced52032baf540a2025-02-03T01:07:31ZengWileyMediators of Inflammation0962-93511466-18612008-01-01200810.1155/2008/289453289453COX-2 Gene Promoter Polymorphism and Coronary Artery Disease in Middle-Aged Men: The Helsinki Sudden Death StudyKati H. Huuskonen0Tarja A. Kunnas1Minna M. Tanner2Jussi Mikkelsson3Erkki Ilveskoski4Pekka J. Karhunen5Seppo T. Nikkari6Department of Medical Biochemistry, Medical School, University of Tampere, Tampere 33104, FinlandDepartment of Medical Biochemistry, Medical School, University of Tampere, Tampere 33104, FinlandLaboratory of Cancer Genetics, Institute of Medical Technology, University of Tampere, Tampere 33104, FinlandDepartment of Forensic Medicine, Medical School, University of Tampere, Tampere 33104, FinlandDepartment of Forensic Medicine, Medical School, University of Tampere, Tampere 33104, FinlandDepartment of Forensic Medicine, Medical School, University of Tampere, Tampere 33104, FinlandDepartment of Medical Biochemistry, Medical School, University of Tampere, Tampere 33104, FinlandCyclooxygenase (COX) catalyzes formation of prostaglandins that contribute to the inflammation in atherosclerosis. Our objective was to study whether the functional C variant of the −765G→C polymorphism in the human COX-2 gene associates with the severity of coronary atherosclerosis measured at the coronary artery level. The Helsinki sudden death study autopsy material (n = 300) comprised of Finnish men who died suddenly. The area of atherosclerotic lesions in the coronary arteries was quantitated, and coronary narrowing was measured. The occurrence of myocardial infarction (MI) was assessed. Genotyping was by restriction endonuclease analysis. Men carrying the minor C allele had larger areas of complicated lesions (P = .024) and a higher number of coronary arteries that had over 50% stenosis (P = .036) compared to men representing the common GG genotype. The COX-2 polymorphism was not associated with MI. Our data suggest that COX-2 may be involved in plaque growth.http://dx.doi.org/10.1155/2008/289453 |
| spellingShingle | Kati H. Huuskonen Tarja A. Kunnas Minna M. Tanner Jussi Mikkelsson Erkki Ilveskoski Pekka J. Karhunen Seppo T. Nikkari COX-2 Gene Promoter Polymorphism and Coronary Artery Disease in Middle-Aged Men: The Helsinki Sudden Death Study Mediators of Inflammation |
| title | COX-2 Gene Promoter Polymorphism and Coronary Artery Disease in Middle-Aged Men: The Helsinki Sudden Death Study |
| title_full | COX-2 Gene Promoter Polymorphism and Coronary Artery Disease in Middle-Aged Men: The Helsinki Sudden Death Study |
| title_fullStr | COX-2 Gene Promoter Polymorphism and Coronary Artery Disease in Middle-Aged Men: The Helsinki Sudden Death Study |
| title_full_unstemmed | COX-2 Gene Promoter Polymorphism and Coronary Artery Disease in Middle-Aged Men: The Helsinki Sudden Death Study |
| title_short | COX-2 Gene Promoter Polymorphism and Coronary Artery Disease in Middle-Aged Men: The Helsinki Sudden Death Study |
| title_sort | cox 2 gene promoter polymorphism and coronary artery disease in middle aged men the helsinki sudden death study |
| url | http://dx.doi.org/10.1155/2008/289453 |
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