Diagnostic value of plasma homocysteine for diabetic kidney disease:a meta-analysis
Objective To evaluate the diagnostic value of plasma homocysteine for diabetic kidney disease(DKD).Methods The databases of the Cochran Library,PubMed,CNKI,WanFang Database,and CBM were retrieved by computer for collecting the relative literature about diagnostic value of plasma homocysteine for DKD...
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Editorial Department of Journal of Clinical Nephrology
2016-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57919363&Fpath=home&index=0 |
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| author | CHEN Ren-gui GAO Ping WU Xiao-yan |
| author_facet | CHEN Ren-gui GAO Ping WU Xiao-yan |
| author_sort | CHEN Ren-gui |
| collection | DOAJ |
| description | Objective To evaluate the diagnostic value of plasma homocysteine for diabetic kidney disease(DKD).Methods The databases of the Cochran Library,PubMed,CNKI,WanFang Database,and CBM were retrieved by computer for collecting the relative literature about diagnostic value of plasma homocysteine for DKD from inception to September 20 th,2015.Two reviewers independently and strictly screened literature according to the inclusion and exclusion criteria.The tools of quality assessment of diagnostic accuracy studies(QUADAS) were used to assess the quality of included studies.Meta-analysis was then performed using Meta-Disc 1.4 software.The pooled sensitivity,specificity,positive likehihood ratio,negative likelihood ratio and diagnostic odds ratio(DOR)were calculated,the summary receiver operating characteristic curve(SROC) was drawn,and the area under the curve(AUC) and Q* value were calculated.The publication bias was evaluated using Stata11.0 software.Results A total of 15 studies involving 2964 cases were inculded.The results of metaanalysis showed that the pooled sensitivity was 0.78(95%CI:0.75- 0.80);specificity was 0.85(95%CI:0.83- 0.87);positive likehihood ratio was 5.87(95%CI:3.81- 9.04);negative likelihood ratio was 0.26(95%CI:0.17- 0.39);DOR was 27.02(95%CI:12.52- 58.30);the AUC of SROC was 0.9154;Q* value was 0.8481.Deek’s funnel plot showed that there was no significant publication bias.Conclusions The present research evidence showed that the test of plasma homocysteine has the higher value of diagnosing DKD.Because of an intermediate-level sensitivity,it still needs the test of combination with urine mircoalbumin to reduce missing diagnostic rate. |
| format | Article |
| id | doaj-art-1efe67725d044f57975afd2f32faadd4 |
| institution | DOAJ |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2016-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-1efe67725d044f57975afd2f32faadd42025-08-20T03:09:13ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902016-01-0141241757919363Diagnostic value of plasma homocysteine for diabetic kidney disease:a meta-analysisCHEN Ren-guiGAO PingWU Xiao-yanObjective To evaluate the diagnostic value of plasma homocysteine for diabetic kidney disease(DKD).Methods The databases of the Cochran Library,PubMed,CNKI,WanFang Database,and CBM were retrieved by computer for collecting the relative literature about diagnostic value of plasma homocysteine for DKD from inception to September 20 th,2015.Two reviewers independently and strictly screened literature according to the inclusion and exclusion criteria.The tools of quality assessment of diagnostic accuracy studies(QUADAS) were used to assess the quality of included studies.Meta-analysis was then performed using Meta-Disc 1.4 software.The pooled sensitivity,specificity,positive likehihood ratio,negative likelihood ratio and diagnostic odds ratio(DOR)were calculated,the summary receiver operating characteristic curve(SROC) was drawn,and the area under the curve(AUC) and Q* value were calculated.The publication bias was evaluated using Stata11.0 software.Results A total of 15 studies involving 2964 cases were inculded.The results of metaanalysis showed that the pooled sensitivity was 0.78(95%CI:0.75- 0.80);specificity was 0.85(95%CI:0.83- 0.87);positive likehihood ratio was 5.87(95%CI:3.81- 9.04);negative likelihood ratio was 0.26(95%CI:0.17- 0.39);DOR was 27.02(95%CI:12.52- 58.30);the AUC of SROC was 0.9154;Q* value was 0.8481.Deek’s funnel plot showed that there was no significant publication bias.Conclusions The present research evidence showed that the test of plasma homocysteine has the higher value of diagnosing DKD.Because of an intermediate-level sensitivity,it still needs the test of combination with urine mircoalbumin to reduce missing diagnostic rate.http://www.lcszb.com/thesisDetails?columnId=57919363&Fpath=home&index=0Diabetic nephropathyHomocysteineUrine MircoalbuminDiagnosisMeta-analysis |
| spellingShingle | CHEN Ren-gui GAO Ping WU Xiao-yan Diagnostic value of plasma homocysteine for diabetic kidney disease:a meta-analysis Linchuang shenzangbing zazhi Diabetic nephropathy Homocysteine Urine Mircoalbumin Diagnosis Meta-analysis |
| title | Diagnostic value of plasma homocysteine for diabetic kidney disease:a meta-analysis |
| title_full | Diagnostic value of plasma homocysteine for diabetic kidney disease:a meta-analysis |
| title_fullStr | Diagnostic value of plasma homocysteine for diabetic kidney disease:a meta-analysis |
| title_full_unstemmed | Diagnostic value of plasma homocysteine for diabetic kidney disease:a meta-analysis |
| title_short | Diagnostic value of plasma homocysteine for diabetic kidney disease:a meta-analysis |
| title_sort | diagnostic value of plasma homocysteine for diabetic kidney disease a meta analysis |
| topic | Diabetic nephropathy Homocysteine Urine Mircoalbumin Diagnosis Meta-analysis |
| url | http://www.lcszb.com/thesisDetails?columnId=57919363&Fpath=home&index=0 |
| work_keys_str_mv | AT chenrengui diagnosticvalueofplasmahomocysteinefordiabetickidneydiseaseametaanalysis AT gaoping diagnosticvalueofplasmahomocysteinefordiabetickidneydiseaseametaanalysis AT wuxiaoyan diagnosticvalueofplasmahomocysteinefordiabetickidneydiseaseametaanalysis |