Potential Benefits of Ethanol extract of Anredera cordifolia for Antiobesity of High Fat diet-Induced Obesity in White Male Rat Wistar
Obesity-related deaths continue to rise, and thus losing weight in overweight and obese patients is critical to prevent complications. Anredera cordifolia (Ten,) Steenis, species of succulent plant of the genus Basellaceae, is widely used in herbal medicine to decrease body weight. This study evalu...
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University of Baghdad, College of Science for Women
2024-03-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8666 |
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| author | Rusdiana Rusdiana Rozaimah Zain Hamid Sry Suryani Widjaja Isti Ilmi Fujiati Syafruddin Ilyas Delfitri Munir Deddi Prima Putra Muhammad Rusda Mustafa Mahmud Amin |
| author_facet | Rusdiana Rusdiana Rozaimah Zain Hamid Sry Suryani Widjaja Isti Ilmi Fujiati Syafruddin Ilyas Delfitri Munir Deddi Prima Putra Muhammad Rusda Mustafa Mahmud Amin |
| author_sort | Rusdiana Rusdiana |
| collection | DOAJ |
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Obesity-related deaths continue to rise, and thus losing weight in overweight and obese patients is critical to prevent complications. Anredera cordifolia (Ten,) Steenis, species of succulent plant of the genus Basellaceae, is widely used in herbal medicine to decrease body weight. This study evaluated the potential benefits of Anredera cordifolia ethanol extract to reduce body weight in high-fat diet-induced obesity rat model. This was an experimental with post-test only control group design study involving 36 obese rats. They were divided into two groups: three control groups (K1, K2, K3) and three treatment groups (P1, P2, P3). All the groups were induced with high-fat diet, except K1 control group that received a standard diet. K2 group received no treatment, and K3 group was given orlistat. Whereas, treatment group received Anredera cordifolia ethanol extract at different dose, such as 50 mg/kg BW (P1), 100 mg/kg BW (P2), and 150 mg/kg BW (P3). After 4 weeks of treatment, all groups of rats were sacrificed. ERK levels and PPARγ in abdominal visceral adipose tissue were measured using ELISA and immunohistochemistry. Body weight and abdominal circumference were measured through anthropometric examination. Weight loss was observed in the groups that received 100 and 150 mg/kg BW Anredera cordifolia ethanol extract, followed by the decrease in ERK levels and PPAR expression. Ethanol extract of Anredera cordifolia used as an antiobesity in this study decreased PPARγ transcription factor and reduced ERK levels to inhibit adipogenesis.
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| format | Article |
| id | doaj-art-1efd9a35ec7d4c9b8b361ed90deca6dd |
| institution | DOAJ |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | University of Baghdad, College of Science for Women |
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| series | مجلة بغداد للعلوم |
| spelling | doaj-art-1efd9a35ec7d4c9b8b361ed90deca6dd2025-08-20T03:15:47ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862024-03-0121310.21123/bsj.2023.8666Potential Benefits of Ethanol extract of Anredera cordifolia for Antiobesity of High Fat diet-Induced Obesity in White Male Rat Wistar Rusdiana Rusdiana0https://orcid.org/0000-0002-7308-9291Rozaimah Zain Hamid 1Sry Suryani Widjaja2Isti Ilmi Fujiati3Syafruddin Ilyas4Delfitri Munir5Deddi Prima Putra6https://orcid.org/0000-0002-0930-3150Muhammad Rusda7https://orcid.org/0000-0002-2268-6838Mustafa Mahmud Amin8https://orcid.org/0000-0003-0912-9372Philosophy Doctor in Medicine Program, Faculty of Medicine,Universitas Sumatera Utara, Medan, IndonesiaDepartment of Biochemistry, Faculty of Medicine, Universitas Sumatera Utara, Medan, IndonesiaDepartment of Pharmacology, Faculty of Medicine, Universitas Sumatera Utara, Medan, IndonesiaDepartment of Community Medicine, Public Health, Faculty of Medicine, Universitas Sumatera Utara, Medan Indonesia Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, IndonesiaDepartment of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, IndonesiaFaculty of Pharmacy, Universitas Andalas, Padang, IndonesiaDepartment of Obstetrics and Gynaecology, Medical Faculty, Universitas Sumatera UtaraDepartment of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia Obesity-related deaths continue to rise, and thus losing weight in overweight and obese patients is critical to prevent complications. Anredera cordifolia (Ten,) Steenis, species of succulent plant of the genus Basellaceae, is widely used in herbal medicine to decrease body weight. This study evaluated the potential benefits of Anredera cordifolia ethanol extract to reduce body weight in high-fat diet-induced obesity rat model. This was an experimental with post-test only control group design study involving 36 obese rats. They were divided into two groups: three control groups (K1, K2, K3) and three treatment groups (P1, P2, P3). All the groups were induced with high-fat diet, except K1 control group that received a standard diet. K2 group received no treatment, and K3 group was given orlistat. Whereas, treatment group received Anredera cordifolia ethanol extract at different dose, such as 50 mg/kg BW (P1), 100 mg/kg BW (P2), and 150 mg/kg BW (P3). After 4 weeks of treatment, all groups of rats were sacrificed. ERK levels and PPARγ in abdominal visceral adipose tissue were measured using ELISA and immunohistochemistry. Body weight and abdominal circumference were measured through anthropometric examination. Weight loss was observed in the groups that received 100 and 150 mg/kg BW Anredera cordifolia ethanol extract, followed by the decrease in ERK levels and PPAR expression. Ethanol extract of Anredera cordifolia used as an antiobesity in this study decreased PPARγ transcription factor and reduced ERK levels to inhibit adipogenesis. https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8666Anredera cordifolia, Rat obesity model, High fat diet, ERK levels, PPARγ |
| spellingShingle | Rusdiana Rusdiana Rozaimah Zain Hamid Sry Suryani Widjaja Isti Ilmi Fujiati Syafruddin Ilyas Delfitri Munir Deddi Prima Putra Muhammad Rusda Mustafa Mahmud Amin Potential Benefits of Ethanol extract of Anredera cordifolia for Antiobesity of High Fat diet-Induced Obesity in White Male Rat Wistar مجلة بغداد للعلوم Anredera cordifolia, Rat obesity model, High fat diet, ERK levels, PPARγ |
| title | Potential Benefits of Ethanol extract of Anredera cordifolia for Antiobesity of High Fat diet-Induced Obesity in White Male Rat Wistar |
| title_full | Potential Benefits of Ethanol extract of Anredera cordifolia for Antiobesity of High Fat diet-Induced Obesity in White Male Rat Wistar |
| title_fullStr | Potential Benefits of Ethanol extract of Anredera cordifolia for Antiobesity of High Fat diet-Induced Obesity in White Male Rat Wistar |
| title_full_unstemmed | Potential Benefits of Ethanol extract of Anredera cordifolia for Antiobesity of High Fat diet-Induced Obesity in White Male Rat Wistar |
| title_short | Potential Benefits of Ethanol extract of Anredera cordifolia for Antiobesity of High Fat diet-Induced Obesity in White Male Rat Wistar |
| title_sort | potential benefits of ethanol extract of anredera cordifolia for antiobesity of high fat diet induced obesity in white male rat wistar |
| topic | Anredera cordifolia, Rat obesity model, High fat diet, ERK levels, PPARγ |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8666 |
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