Shedding Light on a New Treatment for Diabetic Wound Healing: A Review on Phototherapy
Impaired wound healing is a common complication associated with diabetes with complex pathophysiological underlying mechanisms and often necessitates amputation. With the advancement in laser technology, irradiation of these wounds with low-intensity laser irradiation (LILI) or phototherapy, has sho...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/398412 |
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| _version_ | 1849306864211197952 |
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| author | Nicolette N. Houreld |
| author_facet | Nicolette N. Houreld |
| author_sort | Nicolette N. Houreld |
| collection | DOAJ |
| description | Impaired wound healing is a common complication associated with diabetes with complex pathophysiological underlying mechanisms and often necessitates amputation. With the advancement in laser technology, irradiation of these wounds with low-intensity laser irradiation (LILI) or phototherapy, has shown a vast improvement in wound healing. At the correct laser parameters, LILI has shown to increase migration, viability, and proliferation of diabetic cells in vitro; there is a stimulatory effect on the mitochondria with a resulting increase in adenosine triphosphate (ATP). In addition, LILI also has an anti-inflammatory and protective effect on these cells. In light of the ever present threat of diabetic foot ulcers, infection, and amputation, new improved therapies and the fortification of wound healing research deserves better prioritization. In this review we look at the complications associated with diabetic wound healing and the effect of laser irradiation both in vitro and in vivo in diabetic wound healing. |
| format | Article |
| id | doaj-art-1efbd48019fb4159a46f2c01d5182749 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-1efbd48019fb4159a46f2c01d51827492025-08-20T03:54:57ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/398412398412Shedding Light on a New Treatment for Diabetic Wound Healing: A Review on PhototherapyNicolette N. Houreld0Laser Research Center, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein 2028, South AfricaImpaired wound healing is a common complication associated with diabetes with complex pathophysiological underlying mechanisms and often necessitates amputation. With the advancement in laser technology, irradiation of these wounds with low-intensity laser irradiation (LILI) or phototherapy, has shown a vast improvement in wound healing. At the correct laser parameters, LILI has shown to increase migration, viability, and proliferation of diabetic cells in vitro; there is a stimulatory effect on the mitochondria with a resulting increase in adenosine triphosphate (ATP). In addition, LILI also has an anti-inflammatory and protective effect on these cells. In light of the ever present threat of diabetic foot ulcers, infection, and amputation, new improved therapies and the fortification of wound healing research deserves better prioritization. In this review we look at the complications associated with diabetic wound healing and the effect of laser irradiation both in vitro and in vivo in diabetic wound healing.http://dx.doi.org/10.1155/2014/398412 |
| spellingShingle | Nicolette N. Houreld Shedding Light on a New Treatment for Diabetic Wound Healing: A Review on Phototherapy The Scientific World Journal |
| title | Shedding Light on a New Treatment for Diabetic Wound Healing: A Review on Phototherapy |
| title_full | Shedding Light on a New Treatment for Diabetic Wound Healing: A Review on Phototherapy |
| title_fullStr | Shedding Light on a New Treatment for Diabetic Wound Healing: A Review on Phototherapy |
| title_full_unstemmed | Shedding Light on a New Treatment for Diabetic Wound Healing: A Review on Phototherapy |
| title_short | Shedding Light on a New Treatment for Diabetic Wound Healing: A Review on Phototherapy |
| title_sort | shedding light on a new treatment for diabetic wound healing a review on phototherapy |
| url | http://dx.doi.org/10.1155/2014/398412 |
| work_keys_str_mv | AT nicolettenhoureld sheddinglightonanewtreatmentfordiabeticwoundhealingareviewonphototherapy |