Periodontitis Frequently Exists in Patients with Colorectal Carcinoma and Causes Supplementary Impairment of Insulin Resistance
<b>Background:</b> There are known associations between periodontitis and colorectal cancer, but knowledge on the connections existing between the two are not fully understood. The aim of our study was to assess prevalence and clinical severity of periodontitis in patients with localized...
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2025-06-01
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| author | Mario Zivkovic Marko Boban Domagoj Vrazic Ivan Vulic Ivan Budimir Nina Blazevic Aleksandar Vcev Marko Nikolic |
| author_facet | Mario Zivkovic Marko Boban Domagoj Vrazic Ivan Vulic Ivan Budimir Nina Blazevic Aleksandar Vcev Marko Nikolic |
| author_sort | Mario Zivkovic |
| collection | DOAJ |
| description | <b>Background:</b> There are known associations between periodontitis and colorectal cancer, but knowledge on the connections existing between the two are not fully understood. The aim of our study was to assess prevalence and clinical severity of periodontitis in patients with localized colorectal cancer. Secondly, the dynamics of metabolic derangements, particularly glucose metabolism, insulin resistance, and diabetes mellitus were studied as well. <b>Methods:</b> Diagnostic procedures included endoscopies with patohistology, laboratory exams, the insulin resistance homeostatic model assessment method (HOMA index), anthropometrics, and radiology imaging. Periodontal status was evaluated by full-mouth periodontal examination. <b>Results:</b> A total of 79 patients with localized colorectal carcinoma, with slight male predominance of 55.7%, and an age of 65.7 ± 12.4 years participated in this study. Three-quarters of patients (73.4%; 95% CI: 63.0–82.2%) were diagnosed with periodontitis. Patients with periodontitis and colorectal cancer had significantly increased glucose levels (fasting and after oral glucose challenge), (both <i>p</i> < 0.05). Also, increased values of the HOMA index were found in patients with periodontitis vs. controls (without periodontitis) and colorectal cancer; 6.38 ± 5.74 vs. 3.58 ± 2.6 (<i>p</i> = 0.012); Spearman’s Rho correlation coefficient = 0.271 (<i>p</i> = 0.039). There were significant differences in high-density cholesterol in patients with periodontitis vs. controls, 1.41 ± 0.28 vs. 1.23 ± 0.35 mmol/L (<i>p</i> = 0.016), but correlations were insignificant; Rho c.c. = 0.045 (<i>p</i> = 0.738). <b>Conclusions:</b> The most consorted connections between periodontitis and colorectal cancer were found among parameters of metabolic domain, especially glucose concentrations and insulin resistance. Further studies, which would include novel and emerging antidiabetic treatments and their effects on the prevention or control of both diseases, would be warranted. |
| format | Article |
| id | doaj-art-1ef6c0effeac4dd7a1709bebbb6e1350 |
| institution | Kabale University |
| issn | 2218-1989 |
| language | English |
| publishDate | 2025-06-01 |
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| spelling | doaj-art-1ef6c0effeac4dd7a1709bebbb6e13502025-08-20T03:27:18ZengMDPI AGMetabolites2218-19892025-06-0115641410.3390/metabo15060414Periodontitis Frequently Exists in Patients with Colorectal Carcinoma and Causes Supplementary Impairment of Insulin ResistanceMario Zivkovic0Marko Boban1Domagoj Vrazic2Ivan Vulic3Ivan Budimir4Nina Blazevic5Aleksandar Vcev6Marko Nikolic7Internal Medicine Clinic, Department of Gastroenterology, University Hospital “ Sestre Milosrdnice”, Vinogradska Cesta 29, 10000 Zagreb, CroatiaFaculty of Dental Medicine and Health Osijek, University JJ Strossmayer Osijek, Crkvena 21, 31000 Osijek, CroatiaSchool of Dental Medicine, University of Zagreb, Gunduliceva 5, 10000 Zagreb, CroatiaDepartment of Internal Medicine, General Hospital Pula, Santoriova Ulica 24a, 52100 Pula, CroatiaInternal Medicine Clinic, Department of Gastroenterology, University Hospital “ Sestre Milosrdnice”, Vinogradska Cesta 29, 10000 Zagreb, CroatiaInternal Medicine Clinic, Department of Gastroenterology, University Hospital “ Sestre Milosrdnice”, Vinogradska Cesta 29, 10000 Zagreb, CroatiaFaculty of Dental Medicine and Health Osijek, University JJ Strossmayer Osijek, Crkvena 21, 31000 Osijek, CroatiaInternal Medicine Clinic, Department of Gastroenterology, University Hospital “ Sestre Milosrdnice”, Vinogradska Cesta 29, 10000 Zagreb, Croatia<b>Background:</b> There are known associations between periodontitis and colorectal cancer, but knowledge on the connections existing between the two are not fully understood. The aim of our study was to assess prevalence and clinical severity of periodontitis in patients with localized colorectal cancer. Secondly, the dynamics of metabolic derangements, particularly glucose metabolism, insulin resistance, and diabetes mellitus were studied as well. <b>Methods:</b> Diagnostic procedures included endoscopies with patohistology, laboratory exams, the insulin resistance homeostatic model assessment method (HOMA index), anthropometrics, and radiology imaging. Periodontal status was evaluated by full-mouth periodontal examination. <b>Results:</b> A total of 79 patients with localized colorectal carcinoma, with slight male predominance of 55.7%, and an age of 65.7 ± 12.4 years participated in this study. Three-quarters of patients (73.4%; 95% CI: 63.0–82.2%) were diagnosed with periodontitis. Patients with periodontitis and colorectal cancer had significantly increased glucose levels (fasting and after oral glucose challenge), (both <i>p</i> < 0.05). Also, increased values of the HOMA index were found in patients with periodontitis vs. controls (without periodontitis) and colorectal cancer; 6.38 ± 5.74 vs. 3.58 ± 2.6 (<i>p</i> = 0.012); Spearman’s Rho correlation coefficient = 0.271 (<i>p</i> = 0.039). There were significant differences in high-density cholesterol in patients with periodontitis vs. controls, 1.41 ± 0.28 vs. 1.23 ± 0.35 mmol/L (<i>p</i> = 0.016), but correlations were insignificant; Rho c.c. = 0.045 (<i>p</i> = 0.738). <b>Conclusions:</b> The most consorted connections between periodontitis and colorectal cancer were found among parameters of metabolic domain, especially glucose concentrations and insulin resistance. Further studies, which would include novel and emerging antidiabetic treatments and their effects on the prevention or control of both diseases, would be warranted.https://www.mdpi.com/2218-1989/15/6/414colorectal carcinomaperiodontitisdiabetes mellitusglucose intoleranceinsulin resistanceHOMA |
| spellingShingle | Mario Zivkovic Marko Boban Domagoj Vrazic Ivan Vulic Ivan Budimir Nina Blazevic Aleksandar Vcev Marko Nikolic Periodontitis Frequently Exists in Patients with Colorectal Carcinoma and Causes Supplementary Impairment of Insulin Resistance Metabolites colorectal carcinoma periodontitis diabetes mellitus glucose intolerance insulin resistance HOMA |
| title | Periodontitis Frequently Exists in Patients with Colorectal Carcinoma and Causes Supplementary Impairment of Insulin Resistance |
| title_full | Periodontitis Frequently Exists in Patients with Colorectal Carcinoma and Causes Supplementary Impairment of Insulin Resistance |
| title_fullStr | Periodontitis Frequently Exists in Patients with Colorectal Carcinoma and Causes Supplementary Impairment of Insulin Resistance |
| title_full_unstemmed | Periodontitis Frequently Exists in Patients with Colorectal Carcinoma and Causes Supplementary Impairment of Insulin Resistance |
| title_short | Periodontitis Frequently Exists in Patients with Colorectal Carcinoma and Causes Supplementary Impairment of Insulin Resistance |
| title_sort | periodontitis frequently exists in patients with colorectal carcinoma and causes supplementary impairment of insulin resistance |
| topic | colorectal carcinoma periodontitis diabetes mellitus glucose intolerance insulin resistance HOMA |
| url | https://www.mdpi.com/2218-1989/15/6/414 |
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