Mesenchymal Hamartoma in Children: A Diagnostic Challenge
Mesenchymal hamartoma is a benign tumor of the liver with a poorly understood pathogenesis. It is uncommon in older children, especially after 2 years of age. The signs and symptoms may be nonspecific; therefore, a high index of suspicion is required for diagnosis and treatment. We report a 5-year-o...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2019/4132842 |
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| author | Muhammad Rehan Khan Larry A. Binkovitz Thomas C. Smyrk D. Dean Potter Katryn N. Furuya |
| author_facet | Muhammad Rehan Khan Larry A. Binkovitz Thomas C. Smyrk D. Dean Potter Katryn N. Furuya |
| author_sort | Muhammad Rehan Khan |
| collection | DOAJ |
| description | Mesenchymal hamartoma is a benign tumor of the liver with a poorly understood pathogenesis. It is uncommon in older children, especially after 2 years of age. The signs and symptoms may be nonspecific; therefore, a high index of suspicion is required for diagnosis and treatment. We report a 5-year-old previously healthy male who presented with acute abdominal pain, fatigue, and fever. He was diagnosed with pneumonia initially and treated with antibiotics. A computed tomography (CT) scan done for evaluation of his persistent abdominal pain demonstrated a hepatic mass. Follow-up magnetic resonance imaging (MRI) of the liver demonstrated multiple serpiginous tubular-type structures, read as possible Caroli syndrome. He had a normal abdominal examination and normal biochemistries including alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, alkaline phosphatase, and alpha-fetoprotein. He was referred to our institution for second opinion. On further review of his imaging studies, the lesion was thought to be a mesenchymal hamartoma. He subsequently underwent resection of the mass. Pathology confirmed the diagnosis of mesenchymal hamartoma. |
| format | Article |
| id | doaj-art-1eefe62e72a24837ab2c3239da1b98db |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-1eefe62e72a24837ab2c3239da1b98db2025-02-03T07:25:16ZengWileyCase Reports in Pediatrics2090-68032090-68112019-01-01201910.1155/2019/41328424132842Mesenchymal Hamartoma in Children: A Diagnostic ChallengeMuhammad Rehan Khan0Larry A. Binkovitz1Thomas C. Smyrk2D. Dean Potter3Katryn N. Furuya4Division of Pediatric Gastroenterology & Hepatology, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USADepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USADepartment of Pathology, Mayo Clinic, Rochester, Minnesota, USADivision of Pediatric Surgery, Department of Surgery, Mayo Clinic, Rochester, Minnesota, USADivision of Pediatric Gastroenterology & Hepatology, Department of Pediatrics, Mayo Clinic, Rochester, Minnesota, USAMesenchymal hamartoma is a benign tumor of the liver with a poorly understood pathogenesis. It is uncommon in older children, especially after 2 years of age. The signs and symptoms may be nonspecific; therefore, a high index of suspicion is required for diagnosis and treatment. We report a 5-year-old previously healthy male who presented with acute abdominal pain, fatigue, and fever. He was diagnosed with pneumonia initially and treated with antibiotics. A computed tomography (CT) scan done for evaluation of his persistent abdominal pain demonstrated a hepatic mass. Follow-up magnetic resonance imaging (MRI) of the liver demonstrated multiple serpiginous tubular-type structures, read as possible Caroli syndrome. He had a normal abdominal examination and normal biochemistries including alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, alkaline phosphatase, and alpha-fetoprotein. He was referred to our institution for second opinion. On further review of his imaging studies, the lesion was thought to be a mesenchymal hamartoma. He subsequently underwent resection of the mass. Pathology confirmed the diagnosis of mesenchymal hamartoma.http://dx.doi.org/10.1155/2019/4132842 |
| spellingShingle | Muhammad Rehan Khan Larry A. Binkovitz Thomas C. Smyrk D. Dean Potter Katryn N. Furuya Mesenchymal Hamartoma in Children: A Diagnostic Challenge Case Reports in Pediatrics |
| title | Mesenchymal Hamartoma in Children: A Diagnostic Challenge |
| title_full | Mesenchymal Hamartoma in Children: A Diagnostic Challenge |
| title_fullStr | Mesenchymal Hamartoma in Children: A Diagnostic Challenge |
| title_full_unstemmed | Mesenchymal Hamartoma in Children: A Diagnostic Challenge |
| title_short | Mesenchymal Hamartoma in Children: A Diagnostic Challenge |
| title_sort | mesenchymal hamartoma in children a diagnostic challenge |
| url | http://dx.doi.org/10.1155/2019/4132842 |
| work_keys_str_mv | AT muhammadrehankhan mesenchymalhamartomainchildrenadiagnosticchallenge AT larryabinkovitz mesenchymalhamartomainchildrenadiagnosticchallenge AT thomascsmyrk mesenchymalhamartomainchildrenadiagnosticchallenge AT ddeanpotter mesenchymalhamartomainchildrenadiagnosticchallenge AT katrynnfuruya mesenchymalhamartomainchildrenadiagnosticchallenge |