Increased risk of migraine among patients with hidradenitis suppurativa: A US multi-center cohort study
Background: Hidradenitis suppurativa (HS) and migraine share common inflammatory pathways and neuropsychological implications. Both conditions involve proinflammatory cytokines like tumor necrosis factor and are associated with psychological comorbidities. Despite these similarities, the association...
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Elsevier
2025-06-01
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| author | Shuo-Yan Gau Shao-Wei Lo Tsu-Man Chiu Chen‐Pi Li Ru-Yin Tsai Hui-Chin Chang Ching-Chi Chi |
| author_facet | Shuo-Yan Gau Shao-Wei Lo Tsu-Man Chiu Chen‐Pi Li Ru-Yin Tsai Hui-Chin Chang Ching-Chi Chi |
| author_sort | Shuo-Yan Gau |
| collection | DOAJ |
| description | Background: Hidradenitis suppurativa (HS) and migraine share common inflammatory pathways and neuropsychological implications. Both conditions involve proinflammatory cytokines like tumor necrosis factor and are associated with psychological comorbidities. Despite these similarities, the association between HS and migraine remained unclear. This study aimed to evaluate the relation between HS and incident migraine. Materials and methods: We conducted a multicenter cohort study using the TriNetX Research Network. Patients diagnosed with HS between January 1, 2005, and December 31, 2022, were identified with a control group of non-HS subjects established by propensity score matching at a 1:1 ratio. Our outcome was the hazard ratio (HR) of incident migraine in relation to HS. We also examined the HR for various subtypes of migraine. We conducted stratified analyses based on age, gender, insomnia, depression, and anxiety subgroups. Sensitivity analyses were performed to strengthen the robustness of our analysis. Results: The HS group exhibited an increased risk of incident migraine compared to controls (HR 1.35, 95% confidence interval (CI) 1.28–1.42). Also, HS patients had increased risk of migraine with aura and migraine without aura than controls, with HR being 1.36 (95% CI 1.21–1.52), 1.31 (95% CI 1.20–1.45), respectively. Female HS patients demonstrated an increased risk of incident migraine compared to their controls (HR 1.38, 95% CI 1.30–1.45). Elevated risk of incident migraine was observed in both younger and older HS patients when compared to their respective controls. The increased risk of incident migraine among HS patients remained consistent across various sensitivity analyses. Conclusions: HS patients present with an increased risk of incident migraine. Physicians should be aware of this association and provide timely referrals and interventions when appropriate. |
| format | Article |
| id | doaj-art-1eee08e52bf24610bc8336a4d0f1f036 |
| institution | DOAJ |
| issn | 2319-4170 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedical Journal |
| spelling | doaj-art-1eee08e52bf24610bc8336a4d0f1f0362025-08-20T02:44:50ZengElsevierBiomedical Journal2319-41702025-06-0148310081610.1016/j.bj.2024.100816Increased risk of migraine among patients with hidradenitis suppurativa: A US multi-center cohort studyShuo-Yan Gau0Shao-Wei Lo1Tsu-Man Chiu2Chen‐Pi Li3Ru-Yin Tsai4Hui-Chin Chang5Ching-Chi Chi6Department and Graduate Institute of Business Administration, National Taiwan University, Taipei, Taiwan; Department of Pharmacology, Chung Shan Medical University, Taichung, Taiwan; Orthopedics Department, Chi-Mei Medical Center, Tainan, TaiwanHarvard T.H. Chan School of Public Health, Boston, MA, USADepartment of Dermatology, Chung Shan Medical University Hospital, Taichung, Taiwan; School of Medicine, Chung Shan Medical University, Taichung, TaiwanDepartment of Nursing, Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan; Department of Public Health, Chung Shan Medical University, Taichung, TaiwanDepartment of Anatomy, Faculty of Medicine, Chung Shan Medical University, Taichung, Taiwan; Department of Medical Education, Chung Shan Medical University Hospital, Taichung, TaiwanSchool of Medicine, Chung Shan Medical University, Taichung, Taiwan; Evidence-Based Medicine Center, Chung Shan Medical University Hospital, Taichung, Taiwan; Library, Chung Shan Medical University Hospital, Taichung, Taiwan; Corresponding author. Evidence-Based Medicine Center, Chung Shan Medical University Hospital, 110, Sec 1, Jianguo N Rd, South Dist, Taichung 40201, Taiwan.Department of Dermatology, Chang Gung Memorial Hospital, Linkou Main Branch, Taoyuan, Taiwan; School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Corresponding author. Department of Dermatology, Chang Gung Memorial Hospital, Linkou Main Branch, 5, Fuxing St, Guishan Dist, Taoyuan 33305, Taiwan.Background: Hidradenitis suppurativa (HS) and migraine share common inflammatory pathways and neuropsychological implications. Both conditions involve proinflammatory cytokines like tumor necrosis factor and are associated with psychological comorbidities. Despite these similarities, the association between HS and migraine remained unclear. This study aimed to evaluate the relation between HS and incident migraine. Materials and methods: We conducted a multicenter cohort study using the TriNetX Research Network. Patients diagnosed with HS between January 1, 2005, and December 31, 2022, were identified with a control group of non-HS subjects established by propensity score matching at a 1:1 ratio. Our outcome was the hazard ratio (HR) of incident migraine in relation to HS. We also examined the HR for various subtypes of migraine. We conducted stratified analyses based on age, gender, insomnia, depression, and anxiety subgroups. Sensitivity analyses were performed to strengthen the robustness of our analysis. Results: The HS group exhibited an increased risk of incident migraine compared to controls (HR 1.35, 95% confidence interval (CI) 1.28–1.42). Also, HS patients had increased risk of migraine with aura and migraine without aura than controls, with HR being 1.36 (95% CI 1.21–1.52), 1.31 (95% CI 1.20–1.45), respectively. Female HS patients demonstrated an increased risk of incident migraine compared to their controls (HR 1.38, 95% CI 1.30–1.45). Elevated risk of incident migraine was observed in both younger and older HS patients when compared to their respective controls. The increased risk of incident migraine among HS patients remained consistent across various sensitivity analyses. Conclusions: HS patients present with an increased risk of incident migraine. Physicians should be aware of this association and provide timely referrals and interventions when appropriate.http://www.sciencedirect.com/science/article/pii/S2319417024001197Hidradenitis suppurativamigraineCohort studiesTriNetXElectronic medical records |
| spellingShingle | Shuo-Yan Gau Shao-Wei Lo Tsu-Man Chiu Chen‐Pi Li Ru-Yin Tsai Hui-Chin Chang Ching-Chi Chi Increased risk of migraine among patients with hidradenitis suppurativa: A US multi-center cohort study Biomedical Journal Hidradenitis suppurativa migraine Cohort studies TriNetX Electronic medical records |
| title | Increased risk of migraine among patients with hidradenitis suppurativa: A US multi-center cohort study |
| title_full | Increased risk of migraine among patients with hidradenitis suppurativa: A US multi-center cohort study |
| title_fullStr | Increased risk of migraine among patients with hidradenitis suppurativa: A US multi-center cohort study |
| title_full_unstemmed | Increased risk of migraine among patients with hidradenitis suppurativa: A US multi-center cohort study |
| title_short | Increased risk of migraine among patients with hidradenitis suppurativa: A US multi-center cohort study |
| title_sort | increased risk of migraine among patients with hidradenitis suppurativa a us multi center cohort study |
| topic | Hidradenitis suppurativa migraine Cohort studies TriNetX Electronic medical records |
| url | http://www.sciencedirect.com/science/article/pii/S2319417024001197 |
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