Correlation of tongue coating thickness with microinflammatory state and oral microbiome in maintenance hemodialysis patients
Aim This study investigated the correlation between tongue coating thickness (TCT), micro-inflammatory state (MIS), and oral microbiome in maintenance hemodialysis (MHD) patients.Methods Forty MHD patients (20 thin-tongue coating [BTZ], 20 thick-tongue coating [HTZ]) and 15 healthy controls (DZZ) we...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Journal of Oral Microbiology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/20002297.2025.2488054 |
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| author | Yanqin Zhu Xueyan Zeng Aiping Zhang Bin Lu Mengqi Wu Hong Liu Fenggui Zhu Riyang Lin |
| author_facet | Yanqin Zhu Xueyan Zeng Aiping Zhang Bin Lu Mengqi Wu Hong Liu Fenggui Zhu Riyang Lin |
| author_sort | Yanqin Zhu |
| collection | DOAJ |
| description | Aim This study investigated the correlation between tongue coating thickness (TCT), micro-inflammatory state (MIS), and oral microbiome in maintenance hemodialysis (MHD) patients.Methods Forty MHD patients (20 thin-tongue coating [BTZ], 20 thick-tongue coating [HTZ]) and 15 healthy controls (DZZ) were enrolled. Blood microinflammatory markers were analyzed in all patients. Saliva samples from 15 HTZ, 15 BTZ, and 15 DZZ underwent 16S rRNA sequencing.Results HTZ patients exhibited higher microinflammatory marker levels than BTZ. Oral microbiome species richness in DZZ surpassed that of the MHD groups, with distinct structural differences, particularly between HTZ and DZZ. HTZ showed higher abundances of Actinobacillus, Peptostreptococcus, and Lachnospiraceae NK4A136 group than BTZ. Correlation analysis revealed a positive correlation between the levels of IL-6 and TNF-α and the abundance of Fusobacterium, but a negative correlation with Streptococcus. Additionally, the TNF-α level positively correlated with Campylobacter.Conclusion Thick tongue coating in MHD patients is associated with elevated microinflammation and altered oral microbiome, suggesting a link between inflammation and microbial dysbiosis. |
| format | Article |
| id | doaj-art-1eebfe95b58c40bb96c018c4f0e968a2 |
| institution | OA Journals |
| issn | 2000-2297 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Oral Microbiology |
| spelling | doaj-art-1eebfe95b58c40bb96c018c4f0e968a22025-08-20T02:11:15ZengTaylor & Francis GroupJournal of Oral Microbiology2000-22972025-12-0117110.1080/20002297.2025.2488054Correlation of tongue coating thickness with microinflammatory state and oral microbiome in maintenance hemodialysis patientsYanqin Zhu0Xueyan Zeng1Aiping Zhang2Bin Lu3Mengqi Wu4Hong Liu5Fenggui Zhu6Riyang Lin7Department of Nephrology, Hangzhou TCM Hospital of Zhejiang Chinese Medical University, Hangzhou City, ChinaDepartment of Nephrology, Sichuan Second Hospital of Traditional Chinese Medicine, Chengdu City, ChinaDepartment of Nephrology, Hangzhou TCM Hospital of Zhejiang Chinese Medical University, Hangzhou City, ChinaDepartment of Nephrology, Hangzhou TCM Hospital of Zhejiang Chinese Medical University, Hangzhou City, ChinaDepartment of Nephrology, Hangzhou TCM Hospital of Zhejiang Chinese Medical University, Hangzhou City, ChinaDepartment of Nephrology, Hangzhou TCM Hospital of Zhejiang Chinese Medical University, Hangzhou City, ChinaDepartment of Nephrology, Hangzhou TCM Hospital of Zhejiang Chinese Medical University, Hangzhou City, ChinaDepartment of Nephrology, Hangzhou TCM Hospital of Zhejiang Chinese Medical University, Hangzhou City, ChinaAim This study investigated the correlation between tongue coating thickness (TCT), micro-inflammatory state (MIS), and oral microbiome in maintenance hemodialysis (MHD) patients.Methods Forty MHD patients (20 thin-tongue coating [BTZ], 20 thick-tongue coating [HTZ]) and 15 healthy controls (DZZ) were enrolled. Blood microinflammatory markers were analyzed in all patients. Saliva samples from 15 HTZ, 15 BTZ, and 15 DZZ underwent 16S rRNA sequencing.Results HTZ patients exhibited higher microinflammatory marker levels than BTZ. Oral microbiome species richness in DZZ surpassed that of the MHD groups, with distinct structural differences, particularly between HTZ and DZZ. HTZ showed higher abundances of Actinobacillus, Peptostreptococcus, and Lachnospiraceae NK4A136 group than BTZ. Correlation analysis revealed a positive correlation between the levels of IL-6 and TNF-α and the abundance of Fusobacterium, but a negative correlation with Streptococcus. Additionally, the TNF-α level positively correlated with Campylobacter.Conclusion Thick tongue coating in MHD patients is associated with elevated microinflammation and altered oral microbiome, suggesting a link between inflammation and microbial dysbiosis.https://www.tandfonline.com/doi/10.1080/20002297.2025.2488054Maintenance hemodialysistongue coating thicknessmicroinflammatory status16S rRNA sequencingoral microbiome |
| spellingShingle | Yanqin Zhu Xueyan Zeng Aiping Zhang Bin Lu Mengqi Wu Hong Liu Fenggui Zhu Riyang Lin Correlation of tongue coating thickness with microinflammatory state and oral microbiome in maintenance hemodialysis patients Journal of Oral Microbiology Maintenance hemodialysis tongue coating thickness microinflammatory status 16S rRNA sequencing oral microbiome |
| title | Correlation of tongue coating thickness with microinflammatory state and oral microbiome in maintenance hemodialysis patients |
| title_full | Correlation of tongue coating thickness with microinflammatory state and oral microbiome in maintenance hemodialysis patients |
| title_fullStr | Correlation of tongue coating thickness with microinflammatory state and oral microbiome in maintenance hemodialysis patients |
| title_full_unstemmed | Correlation of tongue coating thickness with microinflammatory state and oral microbiome in maintenance hemodialysis patients |
| title_short | Correlation of tongue coating thickness with microinflammatory state and oral microbiome in maintenance hemodialysis patients |
| title_sort | correlation of tongue coating thickness with microinflammatory state and oral microbiome in maintenance hemodialysis patients |
| topic | Maintenance hemodialysis tongue coating thickness microinflammatory status 16S rRNA sequencing oral microbiome |
| url | https://www.tandfonline.com/doi/10.1080/20002297.2025.2488054 |
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