Therapeutic potential of seaweeds and their biofabricated nanoparticles in treating urolithiasis: A review
Urolithiasis affects a significant portion of the global population, causing discomfort and pain. Unfortunately, effective drugs to treat this disorder are currently unavailable due to multiple mechanisms and an incomplete understanding of its causes. Consequently, drugs with multiple targets could...
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Elsevier
2025-01-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024171630 |
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| author | Dhanya Raj C. T Vivekanandan Palaninathan Surabhi Kandaswamy Vimal Kumar Rathinam Arthur James |
| author_facet | Dhanya Raj C. T Vivekanandan Palaninathan Surabhi Kandaswamy Vimal Kumar Rathinam Arthur James |
| author_sort | Dhanya Raj C. T |
| collection | DOAJ |
| description | Urolithiasis affects a significant portion of the global population, causing discomfort and pain. Unfortunately, effective drugs to treat this disorder are currently unavailable due to multiple mechanisms and an incomplete understanding of its causes. Consequently, drugs with multiple targets could be a safer and more effective remedy for treating urolithiasis. Moreover, the current treatment options are expensive and come with a risk of complications and stone recurrence. Therefore, an alternative treatment that can prevent stone recurrence and reduce associated symptoms is necessary. Seaweeds are a rich source of beneficial metabolites, like antioxidants, anti-inflammatory, analgesic, and enzyme-inhibitory properties. Advances in nanotechnology hold great promise for improving the therapeutic potential of these metabolites. However, the use of nanoparticles for treating urolithiasis has yet to be explored well, and only a few reports exist on the use of terrestrial plant-based nanoparticles. This review examines the therapeutic properties of seaweed bioactive compounds and their possible applications in treating urolithiasis. We propose that seaweeds could be an excellent source of essential dietary minerals and other bioactive compounds with multiple targets to treat renal calculus naturally. Additionally, the review highlights the potential of nanomedicine in treating urolithiasis, proposing seaweed-based nanoparticles as a promising treatment option. |
| format | Article |
| id | doaj-art-1ee42eede3c6474a8c1b491f7db52500 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-1ee42eede3c6474a8c1b491f7db525002025-01-17T04:50:15ZengElsevierHeliyon2405-84402025-01-01111e41132Therapeutic potential of seaweeds and their biofabricated nanoparticles in treating urolithiasis: A reviewDhanya Raj C. T0Vivekanandan Palaninathan1Surabhi Kandaswamy2Vimal Kumar3Rathinam Arthur James4Department of Marine Science, Bharathidasan University, Tiruchirappalli, 620024, Tamilnadu, IndiaBio-nano Electronics Research Centre, Toyo University, 2100 Kujirai, Kawagoe, Saitama, Japan; Corresponding author.School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, Lancashire, PR1 2HE, UKBio-nano Electronics Research Centre, Toyo University, 2100 Kujirai, Kawagoe, Saitama, JapanDepartment of Marine Science, Bharathidasan University, Tiruchirappalli, 620024, Tamilnadu, India; Corresponding author. Department of Marine Science, Bharathidasan University, Tiruchirappalli, 620 024, Tamil Nadu, India.Urolithiasis affects a significant portion of the global population, causing discomfort and pain. Unfortunately, effective drugs to treat this disorder are currently unavailable due to multiple mechanisms and an incomplete understanding of its causes. Consequently, drugs with multiple targets could be a safer and more effective remedy for treating urolithiasis. Moreover, the current treatment options are expensive and come with a risk of complications and stone recurrence. Therefore, an alternative treatment that can prevent stone recurrence and reduce associated symptoms is necessary. Seaweeds are a rich source of beneficial metabolites, like antioxidants, anti-inflammatory, analgesic, and enzyme-inhibitory properties. Advances in nanotechnology hold great promise for improving the therapeutic potential of these metabolites. However, the use of nanoparticles for treating urolithiasis has yet to be explored well, and only a few reports exist on the use of terrestrial plant-based nanoparticles. This review examines the therapeutic properties of seaweed bioactive compounds and their possible applications in treating urolithiasis. We propose that seaweeds could be an excellent source of essential dietary minerals and other bioactive compounds with multiple targets to treat renal calculus naturally. Additionally, the review highlights the potential of nanomedicine in treating urolithiasis, proposing seaweed-based nanoparticles as a promising treatment option.http://www.sciencedirect.com/science/article/pii/S2405844024171630UrolithiasisSeaweedsOxidative stressInflammationNanoparticlesNanomedicine |
| spellingShingle | Dhanya Raj C. T Vivekanandan Palaninathan Surabhi Kandaswamy Vimal Kumar Rathinam Arthur James Therapeutic potential of seaweeds and their biofabricated nanoparticles in treating urolithiasis: A review Heliyon Urolithiasis Seaweeds Oxidative stress Inflammation Nanoparticles Nanomedicine |
| title | Therapeutic potential of seaweeds and their biofabricated nanoparticles in treating urolithiasis: A review |
| title_full | Therapeutic potential of seaweeds and their biofabricated nanoparticles in treating urolithiasis: A review |
| title_fullStr | Therapeutic potential of seaweeds and their biofabricated nanoparticles in treating urolithiasis: A review |
| title_full_unstemmed | Therapeutic potential of seaweeds and their biofabricated nanoparticles in treating urolithiasis: A review |
| title_short | Therapeutic potential of seaweeds and their biofabricated nanoparticles in treating urolithiasis: A review |
| title_sort | therapeutic potential of seaweeds and their biofabricated nanoparticles in treating urolithiasis a review |
| topic | Urolithiasis Seaweeds Oxidative stress Inflammation Nanoparticles Nanomedicine |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024171630 |
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