Synthesis, Characterization, Mössbauer Parameters, and Antitumor Activity of Fe(III) Curcumin Complex
Curcumin-Fe(III) complex was prepared from Fe(NO3)3·9H2O precursor and curcumin by refluxing a slightly basic methanolic solution of their mixture with the objective of investigating its cytotoxicity. The enol form of curcumin ligand was established by FTIR, UV/Vis, 1H NMR, and 13C NMR spectroscopy....
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2013/982423 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560927924289536 |
|---|---|
| author | Mutasim Ibrahim Khalil Aisha Mohamed Al-Zahem Maha Hamad Al-Qunaibit |
| author_facet | Mutasim Ibrahim Khalil Aisha Mohamed Al-Zahem Maha Hamad Al-Qunaibit |
| author_sort | Mutasim Ibrahim Khalil |
| collection | DOAJ |
| description | Curcumin-Fe(III) complex was prepared from Fe(NO3)3·9H2O precursor and curcumin by refluxing a slightly basic methanolic solution of their mixture with the objective of investigating its cytotoxicity. The enol form of curcumin ligand was established by FTIR, UV/Vis, 1H NMR, and 13C NMR spectroscopy. The as-prepared product was characterized by elemental analysis, FTIR, UV, and Mössbauer spectroscopic techniques. An octahedral high-spin Fe(III) complex was obtained, δ, 0.37 mms−1; Q.S., 0.79 mms−1; no magnetic relaxation was observed at liquid N2 temperature, neither reduction of Fe(III). The tested cytotoxicity of the as-prepared complex on four cancer cell lines indicated inhibition of the curcumin activity upon complexing with iron. |
| format | Article |
| id | doaj-art-1ee261dad73b456c8b99b20aa83e1344 |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-1ee261dad73b456c8b99b20aa83e13442025-02-03T01:26:20ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2013-01-01201310.1155/2013/982423982423Synthesis, Characterization, Mössbauer Parameters, and Antitumor Activity of Fe(III) Curcumin ComplexMutasim Ibrahim Khalil0Aisha Mohamed Al-Zahem1Maha Hamad Al-Qunaibit2Chemistry Department, King Saud University, Riyadh 11451, Saudi ArabiaChemistry Department, King Saud University, Riyadh 11451, Saudi ArabiaChemistry Department, King Saud University, Riyadh 11451, Saudi ArabiaCurcumin-Fe(III) complex was prepared from Fe(NO3)3·9H2O precursor and curcumin by refluxing a slightly basic methanolic solution of their mixture with the objective of investigating its cytotoxicity. The enol form of curcumin ligand was established by FTIR, UV/Vis, 1H NMR, and 13C NMR spectroscopy. The as-prepared product was characterized by elemental analysis, FTIR, UV, and Mössbauer spectroscopic techniques. An octahedral high-spin Fe(III) complex was obtained, δ, 0.37 mms−1; Q.S., 0.79 mms−1; no magnetic relaxation was observed at liquid N2 temperature, neither reduction of Fe(III). The tested cytotoxicity of the as-prepared complex on four cancer cell lines indicated inhibition of the curcumin activity upon complexing with iron.http://dx.doi.org/10.1155/2013/982423 |
| spellingShingle | Mutasim Ibrahim Khalil Aisha Mohamed Al-Zahem Maha Hamad Al-Qunaibit Synthesis, Characterization, Mössbauer Parameters, and Antitumor Activity of Fe(III) Curcumin Complex Bioinorganic Chemistry and Applications |
| title | Synthesis, Characterization, Mössbauer Parameters, and Antitumor Activity of Fe(III) Curcumin Complex |
| title_full | Synthesis, Characterization, Mössbauer Parameters, and Antitumor Activity of Fe(III) Curcumin Complex |
| title_fullStr | Synthesis, Characterization, Mössbauer Parameters, and Antitumor Activity of Fe(III) Curcumin Complex |
| title_full_unstemmed | Synthesis, Characterization, Mössbauer Parameters, and Antitumor Activity of Fe(III) Curcumin Complex |
| title_short | Synthesis, Characterization, Mössbauer Parameters, and Antitumor Activity of Fe(III) Curcumin Complex |
| title_sort | synthesis characterization mossbauer parameters and antitumor activity of fe iii curcumin complex |
| url | http://dx.doi.org/10.1155/2013/982423 |
| work_keys_str_mv | AT mutasimibrahimkhalil synthesischaracterizationmossbauerparametersandantitumoractivityoffeiiicurcumincomplex AT aishamohamedalzahem synthesischaracterizationmossbauerparametersandantitumoractivityoffeiiicurcumincomplex AT mahahamadalqunaibit synthesischaracterizationmossbauerparametersandantitumoractivityoffeiiicurcumincomplex |