Rescue of protein dyshomeostasis in hippocampal astrocytes from an Alzheimer’s disease mouse model by stabilizing ER-mitochondrial interactions at a 20 nm distance

Rescue of protein dyshomeostasis in hippocampal astrocytes from an Alzheimer’s disease mouse model by stabilizing ER-mitochondrial interactions at a 20 nm distance

Abstract Background Alzheimer’s disease (AD) is the major age-related form of dementia in which dysfunctional ubiquitin-proteasome system (UPS) and autophagy represent primary mechanisms leading to accumulation of misfolded proteins, dysfunction of astroglial cells, neuroinflammation and neurodegene...

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Bibliographic Details
Main Authors: Giulia Dematteis, Chunmei Gong, Justyna Malecka, Elisa Tonelli, Armando Genazzani, Laura Tapella, Anna Maria Eleuteri, Dmitry Lim, Laura Bonfili
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Astrocytes
Proteasome
Immunoproteasome
Autophagy
Lysosomal degradation
Online Access:https://doi.org/10.1186/s13195-025-01793-9
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