Sleep disturbances and progression of mobility disability: Longitudinal findings from the Nurses’ Health Study
Objective: To examine longitudinal associations between self-reported sleep disturbances and mobility disability progression among women, including subgroups with multiple sclerosis (MS), diabetes, and osteoarthritis (OA). Methods: Prospective cohort study using data from Nurses’ Health Study long-f...
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Elsevier
2024-12-01
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| Series: | Sleep Epidemiology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667343623000161 |
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| author | Daniel Whibley Monica M. Shieu Galit Levi Dunietz Tiffany J. Braley |
| author_facet | Daniel Whibley Monica M. Shieu Galit Levi Dunietz Tiffany J. Braley |
| author_sort | Daniel Whibley |
| collection | DOAJ |
| description | Objective: To examine longitudinal associations between self-reported sleep disturbances and mobility disability progression among women, including subgroups with multiple sclerosis (MS), diabetes, and osteoarthritis (OA). Methods: Prospective cohort study using data from Nurses’ Health Study long-form questionnaires (2008, 2012, 2014, 2016). Logistic regression was used to quantify associations between sleep-related variables at baseline and subsequent increase in mobility disability. Results: Of 70,303 women (mean age 73), 392 had MS, 7,302 had diabetes, and 24,099 had OA. Between 2008–2016, mobility disability increased by 16.9 % overall, 27.8 % in the MS subgroup, 27.0 % in the diabetes subgroup, and 23.7 % in the OA subgroup. Known/suspected obstructive sleep apnea was significantly associated with an increase in mobility disability between 2008 and 2016, overall (OR:1.4, 95 %CI:1.2,1.5), and in the diabetes (OR:1.5, 95 %CI:1.2,1.9) and OA subgroups (OR:1.2, 95 %CI:1.0,1.4), but not in the MS subgroup (OR:2.3, 95 %CI:0.6,8.9); however, across 2012–2016, this association was significant for MS (OR:4.0, 95 %CI:1.0,16.1). Suboptimal sleep duration was significantly associated with increased odds of mobility disability progression overall, but not in disease subgroups. Perception of adequate sleep was associated with lower odds of mobility disability progression overall (OR:0.82, 95 %CI:0.78,0.87) and for the OA subgroup (OR:0.83, 95 %CI:0.76,0.91). Excessive daytime sleepiness was associated with mobility disability progression overall (OR:1.2, 95 %CI:1.1,1.4) and for the OA subgroup (OR:1.2, 95 %CI:1.0,1.4). Conclusions: Prevalent sleep disturbances could increase disability progression among women. Chronic disease populations may be uniquely vulnerable. Informed by these data, future research could offer new insight into sleep-based strategies to ameliorate mobility decline. |
| format | Article |
| id | doaj-art-1edf81ff6a8748d1a6567d1df14ec95c |
| institution | OA Journals |
| issn | 2667-3436 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Sleep Epidemiology |
| spelling | doaj-art-1edf81ff6a8748d1a6567d1df14ec95c2025-08-20T01:59:09ZengElsevierSleep Epidemiology2667-34362024-12-01410007110.1016/j.sleepe.2023.100071Sleep disturbances and progression of mobility disability: Longitudinal findings from the Nurses’ Health StudyDaniel Whibley0Monica M. Shieu1Galit Levi Dunietz2Tiffany J. Braley3Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA; Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, MI, USA; Corresponding author at: Department of Physical Medicine and Rehabilitation, Michigan Medicine, University of Michigan, North Campus Research Complex, Building 16, Room G018W, 2800 Plymouth Road, Ann Arbor, MI 48109.Department of Neurology, Divisions of Neuroimmunology/Multiple Sclerosis and Sleep Medicine, University of Michigan Ann Arbor, MI, USAInstitute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, MI, USA; Department of Neurology, Divisions of Neuroimmunology/Multiple Sclerosis and Sleep Medicine, University of Michigan Ann Arbor, MI, USAInstitute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, MI, USA; Department of Neurology, Divisions of Neuroimmunology/Multiple Sclerosis and Sleep Medicine, University of Michigan Ann Arbor, MI, USAObjective: To examine longitudinal associations between self-reported sleep disturbances and mobility disability progression among women, including subgroups with multiple sclerosis (MS), diabetes, and osteoarthritis (OA). Methods: Prospective cohort study using data from Nurses’ Health Study long-form questionnaires (2008, 2012, 2014, 2016). Logistic regression was used to quantify associations between sleep-related variables at baseline and subsequent increase in mobility disability. Results: Of 70,303 women (mean age 73), 392 had MS, 7,302 had diabetes, and 24,099 had OA. Between 2008–2016, mobility disability increased by 16.9 % overall, 27.8 % in the MS subgroup, 27.0 % in the diabetes subgroup, and 23.7 % in the OA subgroup. Known/suspected obstructive sleep apnea was significantly associated with an increase in mobility disability between 2008 and 2016, overall (OR:1.4, 95 %CI:1.2,1.5), and in the diabetes (OR:1.5, 95 %CI:1.2,1.9) and OA subgroups (OR:1.2, 95 %CI:1.0,1.4), but not in the MS subgroup (OR:2.3, 95 %CI:0.6,8.9); however, across 2012–2016, this association was significant for MS (OR:4.0, 95 %CI:1.0,16.1). Suboptimal sleep duration was significantly associated with increased odds of mobility disability progression overall, but not in disease subgroups. Perception of adequate sleep was associated with lower odds of mobility disability progression overall (OR:0.82, 95 %CI:0.78,0.87) and for the OA subgroup (OR:0.83, 95 %CI:0.76,0.91). Excessive daytime sleepiness was associated with mobility disability progression overall (OR:1.2, 95 %CI:1.1,1.4) and for the OA subgroup (OR:1.2, 95 %CI:1.0,1.4). Conclusions: Prevalent sleep disturbances could increase disability progression among women. Chronic disease populations may be uniquely vulnerable. Informed by these data, future research could offer new insight into sleep-based strategies to ameliorate mobility decline.http://www.sciencedirect.com/science/article/pii/S2667343623000161EpidemiologyWomen's healthObstructive sleep apneaSleepinessAging |
| spellingShingle | Daniel Whibley Monica M. Shieu Galit Levi Dunietz Tiffany J. Braley Sleep disturbances and progression of mobility disability: Longitudinal findings from the Nurses’ Health Study Sleep Epidemiology Epidemiology Women's health Obstructive sleep apnea Sleepiness Aging |
| title | Sleep disturbances and progression of mobility disability: Longitudinal findings from the Nurses’ Health Study |
| title_full | Sleep disturbances and progression of mobility disability: Longitudinal findings from the Nurses’ Health Study |
| title_fullStr | Sleep disturbances and progression of mobility disability: Longitudinal findings from the Nurses’ Health Study |
| title_full_unstemmed | Sleep disturbances and progression of mobility disability: Longitudinal findings from the Nurses’ Health Study |
| title_short | Sleep disturbances and progression of mobility disability: Longitudinal findings from the Nurses’ Health Study |
| title_sort | sleep disturbances and progression of mobility disability longitudinal findings from the nurses health study |
| topic | Epidemiology Women's health Obstructive sleep apnea Sleepiness Aging |
| url | http://www.sciencedirect.com/science/article/pii/S2667343623000161 |
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