Relative radiosensitivity of Arabidopsis thaliana Atmsh2 SALK_002708 mutant in the sublethal dose range of radiation
Effective repair of radiation-induced DNA lesions is an important factor in the radioresistance of plants. Taking into account the role of the DNA mismatch repair (MMR) in the systemic reaction of plants to the action of sublethal doses of ionizing radiation has not yet been sufficiently clear enoug...
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| Format: | Article |
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Institute for Nuclear Research, National Academy of Sciences of Ukraine
2018-06-01
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| Series: | Ядерна фізика та енергетика |
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| Online Access: | http://jnpae.kinr.kiev.ua/19.2/Articles_PDF/jnpae-2018-19-0145-Litvinov.pdf |
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| author | S. V. Litvinov N. M. Rashydov |
| author_facet | S. V. Litvinov N. M. Rashydov |
| author_sort | S. V. Litvinov |
| collection | DOAJ |
| description | Effective repair of radiation-induced DNA lesions is an important factor in the radioresistance of plants. Taking into account the role of the DNA mismatch repair (MMR) in the systemic reaction of plants to the action of sublethal doses of ionizing radiation has not yet been sufficiently clear enough. The study of the effect of low LET ionizing radiation in doses up to 21 Gy had been performed, including measurement of the biomass accumulation in Arabidopsis thaliana Atmsh2-/- plants, defective in one of the key components of MMR-repair, MSH2 protein. It has been established that the relative radiosensitivity of Atmsh2 SALK_002708 mutants to the action of sublethal doses of radiation depends on the dose and mode of irradiation. Changes in the radiosensitivity of mutant plants at different doses and due to the fractionation of the dose can be related to the radiation-induced transcriptional response of genes, coding DNA repair proteins, which compensate the lack of MMR-repair or along with MSH2 participate in the mutagenic pathways of DNA repair. |
| format | Article |
| id | doaj-art-1edec811690d4771bc851e86e48ffeb3 |
| institution | DOAJ |
| issn | 1818-331X 2074-0565 |
| language | English |
| publishDate | 2018-06-01 |
| publisher | Institute for Nuclear Research, National Academy of Sciences of Ukraine |
| record_format | Article |
| series | Ядерна фізика та енергетика |
| spelling | doaj-art-1edec811690d4771bc851e86e48ffeb32025-08-20T03:17:47ZengInstitute for Nuclear Research, National Academy of Sciences of UkraineЯдерна фізика та енергетика1818-331X2074-05652018-06-0119214514910.15407/jnpae2018.02.145Relative radiosensitivity of Arabidopsis thaliana Atmsh2 SALK_002708 mutant in the sublethal dose range of radiationS. V. Litvinov0N. M. Rashydov 1Institute of Cell Biology and Genetic Engineering, National Academy of Sciences of Ukraine, Kyiv, Ukraine Institute of Cell Biology and Genetic Engineering, National Academy of Sciences of Ukraine, Kyiv, Ukraine Effective repair of radiation-induced DNA lesions is an important factor in the radioresistance of plants. Taking into account the role of the DNA mismatch repair (MMR) in the systemic reaction of plants to the action of sublethal doses of ionizing radiation has not yet been sufficiently clear enough. The study of the effect of low LET ionizing radiation in doses up to 21 Gy had been performed, including measurement of the biomass accumulation in Arabidopsis thaliana Atmsh2-/- plants, defective in one of the key components of MMR-repair, MSH2 protein. It has been established that the relative radiosensitivity of Atmsh2 SALK_002708 mutants to the action of sublethal doses of radiation depends on the dose and mode of irradiation. Changes in the radiosensitivity of mutant plants at different doses and due to the fractionation of the dose can be related to the radiation-induced transcriptional response of genes, coding DNA repair proteins, which compensate the lack of MMR-repair or along with MSH2 participate in the mutagenic pathways of DNA repair.http://jnpae.kinr.kiev.ua/19.2/Articles_PDF/jnpae-2018-19-0145-Litvinov.pdfionizing irradiationsublethal dosesradiosensitivityDNA mismatch repairMSH2. |
| spellingShingle | S. V. Litvinov N. M. Rashydov Relative radiosensitivity of Arabidopsis thaliana Atmsh2 SALK_002708 mutant in the sublethal dose range of radiation Ядерна фізика та енергетика ionizing irradiation sublethal doses radiosensitivity DNA mismatch repair MSH2. |
| title | Relative radiosensitivity of Arabidopsis thaliana Atmsh2 SALK_002708 mutant in the sublethal dose range of radiation |
| title_full | Relative radiosensitivity of Arabidopsis thaliana Atmsh2 SALK_002708 mutant in the sublethal dose range of radiation |
| title_fullStr | Relative radiosensitivity of Arabidopsis thaliana Atmsh2 SALK_002708 mutant in the sublethal dose range of radiation |
| title_full_unstemmed | Relative radiosensitivity of Arabidopsis thaliana Atmsh2 SALK_002708 mutant in the sublethal dose range of radiation |
| title_short | Relative radiosensitivity of Arabidopsis thaliana Atmsh2 SALK_002708 mutant in the sublethal dose range of radiation |
| title_sort | relative radiosensitivity of arabidopsis thaliana atmsh2 salk 002708 mutant in the sublethal dose range of radiation |
| topic | ionizing irradiation sublethal doses radiosensitivity DNA mismatch repair MSH2. |
| url | http://jnpae.kinr.kiev.ua/19.2/Articles_PDF/jnpae-2018-19-0145-Litvinov.pdf |
| work_keys_str_mv | AT svlitvinov relativeradiosensitivityofarabidopsisthalianaatmsh2salk002708mutantinthesublethaldoserangeofradiation AT nmrashydov relativeradiosensitivityofarabidopsisthalianaatmsh2salk002708mutantinthesublethaldoserangeofradiation |