The current status and prospects of gut microbiota combined with PD-1/PD-L1 inhibitors in the treatment of colorectal cancer: a review

The current status and prospects of gut microbiota combined with PD-1/PD-L1 inhibitors in the treatment of colorectal cancer: a review

Abstract Background Colorectal cancer (CRC) is a common malignant tumor. Immune checkpoint inhibitors (ICIs), particularly those targeting programmed cell death protein 1(PD-1) and programmed cell death ligand 1(PD-L1), have shown promising potential in the treatment of CRC. Specific gut microbiota...

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Bibliographic Details
Main Authors: Min Deng, Xiaoyu Li, Huiming Wu, Dingwen Xue, Yize Wang, Renkai Guo, Yipeng Cui, Chenfei Jin, Fei luo, Huiyu Li
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Gastroenterology
Subjects:
Gut microbiota
Colorectal cancer
PD-1
PD-L1
immunotherapy
Systematic review
Online Access:https://doi.org/10.1186/s12876-025-03968-y
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