miR-122 shows potential as a biomarker and therapeutic target in NSCLC by inhibiting WNT/β-catenin and PI3K/AKT pathways and key transcription factors linked to EMT and metastasis
Lung cancer stands as the primary cause of cancer-related mortality on a global scale, necessitating meticulous scrutiny and comprehension of its metastatic propensities. Epithelial-to-mesenchymal transition (EMT) assumes a cardinal position in the evolutionary course of cancer cells. The genesis of...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-03-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025013428 |
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| Summary: | Lung cancer stands as the primary cause of cancer-related mortality on a global scale, necessitating meticulous scrutiny and comprehension of its metastatic propensities. Epithelial-to-mesenchymal transition (EMT) assumes a cardinal position in the evolutionary course of cancer cells. The genesis of these alterations lies in the modulation of genes or proteins associated with epithelial and mesenchymal traits, prominently encompassing entities regulating cell-cell and cell-matrix adhesion. Notable participants in these transformative changes include the PI3K/AKT and WNT/β-catenin signaling pathways and the transcription factors Snail, ZEB, and P4HA1. MicroRNAs, characterized as diminutive non-coding RNA molecules typically spanning 20–25 nucleotides, exert regulatory control over gene expression by binding to the 3′UTR of target mRNAs. Their pivotal role in lung cancer has been subject to extensive investigation due to their profound influence on the developmental trajectory, progression, and behavioral attributes of lung neoplastic cells. miR-122, localized predominantly in hepatic tissues, has undergone comprehensive scrutiny regarding its anti-tumorigenic attributes. This study is dedicated to elucidating the intricate regulatory role of miR-122 in managing the metastatic potential of non-small cell lung cancer (NSCLC). Also, this research to unravel the mechanistic intricacies through which miR-122 modulates the WNT/β-catenin and PI3K/Akt signaling pathways, concurrently influencing Zeb, P4AH1, and Snail transcription factors, ultimately aiming to curtail the metastatic cascade inherent to this subset of lung malignancies. briefly, miR-122 is a promising biomarker and prospective therapeutic target for the diagnosis and prognosis of lung malignancies, but further research is still needed to establish a theoretical basis for more practical applications. |
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| ISSN: | 2405-8440 |