Feedback loop centered on MAF1 reduces blood–brain barrier damage in sepsis-associated encephalopathy

Feedback loop centered on MAF1 reduces blood–brain barrier damage in sepsis-associated encephalopathy

Abstract Background A previous study found that MAF1 homolog, a negative regulator of RNA polymerase III (MAF1), protects the blood–brain barrier (BBB) in sepsis-associated encephalopathy (SAE); however, the related molecular mechanisms remain unclear. Subjects and methods In this study, a rat sepsi...

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Bibliographic Details
Main Authors: Xuebiao Wei, Wenqiang Jiang, Zhonghua Wang, Yichen Li, Yuanwen Jing, Yongli Han, Linqiang Huang, Shenglong Chen
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cellular & Molecular Biology Letters
Subjects:
Sepsis
Blood–brain barrier
MAF1
Ubiquitination
Apoptosis
Online Access:https://doi.org/10.1186/s11658-025-00686-x
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