Photoirradiation‐ and Extracellular‐Matrix‐Encouraged Photon‐Transition Switching Regulates Spatiotemporal Sequential Photoimmunotherapy
As two main phototherapy means, photodynamic therapy (PDT) and photothermal therapy (PTT) have different photon‐transition avenues decided by the aggregation state of photosensitizers (PSs), and thus PDT or PTT efficiency can be regulated by regulating PSs aggregation. A co‐assembly formulation cons...
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Wiley-VCH
2025-07-01
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| Series: | Small Structures |
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| Online Access: | https://doi.org/10.1002/sstr.202400574 |
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| author | Hai Wang Feixiang Hu Wuyang Wei Wencheng Wu Qiaoling Yang Wen Qin Chao Fang Xiulin Dong Yang Zhou Kun Zhang |
| author_facet | Hai Wang Feixiang Hu Wuyang Wei Wencheng Wu Qiaoling Yang Wen Qin Chao Fang Xiulin Dong Yang Zhou Kun Zhang |
| author_sort | Hai Wang |
| collection | DOAJ |
| description | As two main phototherapy means, photodynamic therapy (PDT) and photothermal therapy (PTT) have different photon‐transition avenues decided by the aggregation state of photosensitizers (PSs), and thus PDT or PTT efficiency can be regulated by regulating PSs aggregation. A co‐assembly formulation consisting of IR780 iodide PSs and pentafluorophenyl trifluoroacetate is constructed through intermolecular interactions, followed by coating with hyaluronic acid. Initially, the uniform distribution of IR780 PSs favors more reactive oxygen species birth to implement PDT when entering cells since its photon‐transition avenue through the sequential process intersystem crossing transfer–collision energy transfer is predominant. After hyaluronidase and laser irradiation‐induced structural collapse of co‐assembly, free IR780 aggregates due to hydrophobic interactions even though they are excreted out of cells, and then, these IR780 aggregates produce heat through the nonradiative relaxation process to execute PTT. Such a spatiotemporal sequential PDT–PTT phototherapy encourages antitumor immune responses and mitigates immunosuppression, thus accomplishing the spatiotemporal sequential photoimmunotherapy against breast cancer progression. Through such tumor microenvironment‐adaptable and laser‐duration‐decided aggregation state alteration, photon‐transition switching is regulated and more insights are provided into single PSs‐mediated sequential PDT–PTT and photoimmunotherapy. |
| format | Article |
| id | doaj-art-1ece8f82c2f34d07a649e6e785010132 |
| institution | DOAJ |
| issn | 2688-4062 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Small Structures |
| spelling | doaj-art-1ece8f82c2f34d07a649e6e7850101322025-08-20T02:43:02ZengWiley-VCHSmall Structures2688-40622025-07-0167n/an/a10.1002/sstr.202400574Photoirradiation‐ and Extracellular‐Matrix‐Encouraged Photon‐Transition Switching Regulates Spatiotemporal Sequential PhotoimmunotherapyHai Wang0Feixiang Hu1Wuyang Wei2Wencheng Wu3Qiaoling Yang4Wen Qin5Chao Fang6Xiulin Dong7Yang Zhou8Kun Zhang9Department of Ultrasound The Third People's Hospital of Chendu (Affiliated Hospital of Southwest Jiaotong University) College of Medicine Southwest Jiaotong University No. 19, Yangshi Street Chengdu Sichuan 610031 ChinaDepartment of Radiology Fudan University Shanghai Cancer Center No. 270 Dong'an Road, Xuhui District Shanghai 200032 ChinaDepartment of Ultrasound The Third People's Hospital of Chendu (Affiliated Hospital of Southwest Jiaotong University) College of Medicine Southwest Jiaotong University No. 19, Yangshi Street Chengdu Sichuan 610031 ChinaCentral Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China No. 32, West Second Section, First Ring Road Chengdu Sichuan 610072 ChinaCentral Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China No. 32, West Second Section, First Ring Road Chengdu Sichuan 610072 ChinaCentral Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China No. 32, West Second Section, First Ring Road Chengdu Sichuan 610072 ChinaCentral Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China No. 32, West Second Section, First Ring Road Chengdu Sichuan 610072 ChinaCentral Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China No. 32, West Second Section, First Ring Road Chengdu Sichuan 610072 ChinaDepartment of Ultrasound The Third People's Hospital of Chendu (Affiliated Hospital of Southwest Jiaotong University) College of Medicine Southwest Jiaotong University No. 19, Yangshi Street Chengdu Sichuan 610031 ChinaCentral Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China No. 32, West Second Section, First Ring Road Chengdu Sichuan 610072 ChinaAs two main phototherapy means, photodynamic therapy (PDT) and photothermal therapy (PTT) have different photon‐transition avenues decided by the aggregation state of photosensitizers (PSs), and thus PDT or PTT efficiency can be regulated by regulating PSs aggregation. A co‐assembly formulation consisting of IR780 iodide PSs and pentafluorophenyl trifluoroacetate is constructed through intermolecular interactions, followed by coating with hyaluronic acid. Initially, the uniform distribution of IR780 PSs favors more reactive oxygen species birth to implement PDT when entering cells since its photon‐transition avenue through the sequential process intersystem crossing transfer–collision energy transfer is predominant. After hyaluronidase and laser irradiation‐induced structural collapse of co‐assembly, free IR780 aggregates due to hydrophobic interactions even though they are excreted out of cells, and then, these IR780 aggregates produce heat through the nonradiative relaxation process to execute PTT. Such a spatiotemporal sequential PDT–PTT phototherapy encourages antitumor immune responses and mitigates immunosuppression, thus accomplishing the spatiotemporal sequential photoimmunotherapy against breast cancer progression. Through such tumor microenvironment‐adaptable and laser‐duration‐decided aggregation state alteration, photon‐transition switching is regulated and more insights are provided into single PSs‐mediated sequential PDT–PTT and photoimmunotherapy.https://doi.org/10.1002/sstr.202400574aggregation state regulationsphoton‐transition pathway switchingssingle photosensitizersspatiotemporal sequential phototherapies and photoimmunotherapiestumor microenvironment adaptations |
| spellingShingle | Hai Wang Feixiang Hu Wuyang Wei Wencheng Wu Qiaoling Yang Wen Qin Chao Fang Xiulin Dong Yang Zhou Kun Zhang Photoirradiation‐ and Extracellular‐Matrix‐Encouraged Photon‐Transition Switching Regulates Spatiotemporal Sequential Photoimmunotherapy Small Structures aggregation state regulations photon‐transition pathway switchings single photosensitizers spatiotemporal sequential phototherapies and photoimmunotherapies tumor microenvironment adaptations |
| title | Photoirradiation‐ and Extracellular‐Matrix‐Encouraged Photon‐Transition Switching Regulates Spatiotemporal Sequential Photoimmunotherapy |
| title_full | Photoirradiation‐ and Extracellular‐Matrix‐Encouraged Photon‐Transition Switching Regulates Spatiotemporal Sequential Photoimmunotherapy |
| title_fullStr | Photoirradiation‐ and Extracellular‐Matrix‐Encouraged Photon‐Transition Switching Regulates Spatiotemporal Sequential Photoimmunotherapy |
| title_full_unstemmed | Photoirradiation‐ and Extracellular‐Matrix‐Encouraged Photon‐Transition Switching Regulates Spatiotemporal Sequential Photoimmunotherapy |
| title_short | Photoirradiation‐ and Extracellular‐Matrix‐Encouraged Photon‐Transition Switching Regulates Spatiotemporal Sequential Photoimmunotherapy |
| title_sort | photoirradiation and extracellular matrix encouraged photon transition switching regulates spatiotemporal sequential photoimmunotherapy |
| topic | aggregation state regulations photon‐transition pathway switchings single photosensitizers spatiotemporal sequential phototherapies and photoimmunotherapies tumor microenvironment adaptations |
| url | https://doi.org/10.1002/sstr.202400574 |
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