Tracheobronchial Amyloidosis: A Rare Airway Disorder With Diagnostic and Therapeutic Challenges—A Case Report and Literature Review
ABSTRACT Tracheobronchial amyloidosis (TBA) is a rare, localised form of amyloidosis characterised by the extracellular deposition of abnormal proteins within the tracheal and bronchial tissues. This condition, although uncommon, can significantly impact airway function, leading to symptoms such as...
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| Format: | Article |
| Language: | English |
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Wiley
2025-04-01
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| Series: | Respirology Case Reports |
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| Online Access: | https://doi.org/10.1002/rcr2.70171 |
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| author | Filip Shterev Vladimir Aleksiev Veselin Chonov Boyko Yavorov Stanislav Kartev Dimcho Argirov |
| author_facet | Filip Shterev Vladimir Aleksiev Veselin Chonov Boyko Yavorov Stanislav Kartev Dimcho Argirov |
| author_sort | Filip Shterev |
| collection | DOAJ |
| description | ABSTRACT Tracheobronchial amyloidosis (TBA) is a rare, localised form of amyloidosis characterised by the extracellular deposition of abnormal proteins within the tracheal and bronchial tissues. This condition, although uncommon, can significantly impact airway function, leading to symptoms such as persistent cough, dyspnea and airway obstruction. This report highlights the clinical presentation, diagnostic approaches and therapeutic options for TBA, emphasising the need for individualised management strategies and comprehensive patient care. This case describes a 62‐year‐old male with a history of smoking debuting with progressive hoarseness, dyspnea and dysphagia, who was initially diagnosed with tracheobronchial amyloidosis following biopsy of a subglottic mass. After surgical excision and a 3‐year disease‐free interval, he experienced multiple recurrences requiring further interventions, including bronchoscopic evaluation. Histopathological confirmation of recurrent amyloidosis led to a decision for strict follow‐up, as symptoms remained mild post‐biopsy. |
| format | Article |
| id | doaj-art-1ecdc7ed0b2f44c3958d9c8bacfa6096 |
| institution | OA Journals |
| issn | 2051-3380 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Respirology Case Reports |
| spelling | doaj-art-1ecdc7ed0b2f44c3958d9c8bacfa60962025-08-20T02:29:29ZengWileyRespirology Case Reports2051-33802025-04-01134n/an/a10.1002/rcr2.70171Tracheobronchial Amyloidosis: A Rare Airway Disorder With Diagnostic and Therapeutic Challenges—A Case Report and Literature ReviewFilip Shterev0Vladimir Aleksiev1Veselin Chonov2Boyko Yavorov3Stanislav Kartev4Dimcho Argirov5I‐st Department of Internal Diseases, Section of Pneumology and Phthysiatrics Medical University of Plovdiv Plovdiv BulgariaClinic of Thoracic Surgery Plovdiv University Multiprofile Hospital for Active Treatment Kaspela Plovdiv BulgariaDepartment of Clinical Pathology Plovdiv University Multiprofile Hospital for Active Treatment Kaspela Plovdiv BulgariaClinic of Thoracic Surgery Plovdiv University Multiprofile Hospital for Active Treatment Kaspela Plovdiv BulgariaI‐st Department of Internal Diseases, Section of Pneumology and Phthysiatrics Medical University of Plovdiv Plovdiv BulgariaClinic of Thoracic Surgery Plovdiv University Multiprofile Hospital for Active Treatment Kaspela Plovdiv BulgariaABSTRACT Tracheobronchial amyloidosis (TBA) is a rare, localised form of amyloidosis characterised by the extracellular deposition of abnormal proteins within the tracheal and bronchial tissues. This condition, although uncommon, can significantly impact airway function, leading to symptoms such as persistent cough, dyspnea and airway obstruction. This report highlights the clinical presentation, diagnostic approaches and therapeutic options for TBA, emphasising the need for individualised management strategies and comprehensive patient care. This case describes a 62‐year‐old male with a history of smoking debuting with progressive hoarseness, dyspnea and dysphagia, who was initially diagnosed with tracheobronchial amyloidosis following biopsy of a subglottic mass. After surgical excision and a 3‐year disease‐free interval, he experienced multiple recurrences requiring further interventions, including bronchoscopic evaluation. Histopathological confirmation of recurrent amyloidosis led to a decision for strict follow‐up, as symptoms remained mild post‐biopsy.https://doi.org/10.1002/rcr2.70171airway obstructionbronchoscopyprotein depositiontherapeutic managementtracheobronchial amyloidosis |
| spellingShingle | Filip Shterev Vladimir Aleksiev Veselin Chonov Boyko Yavorov Stanislav Kartev Dimcho Argirov Tracheobronchial Amyloidosis: A Rare Airway Disorder With Diagnostic and Therapeutic Challenges—A Case Report and Literature Review Respirology Case Reports airway obstruction bronchoscopy protein deposition therapeutic management tracheobronchial amyloidosis |
| title | Tracheobronchial Amyloidosis: A Rare Airway Disorder With Diagnostic and Therapeutic Challenges—A Case Report and Literature Review |
| title_full | Tracheobronchial Amyloidosis: A Rare Airway Disorder With Diagnostic and Therapeutic Challenges—A Case Report and Literature Review |
| title_fullStr | Tracheobronchial Amyloidosis: A Rare Airway Disorder With Diagnostic and Therapeutic Challenges—A Case Report and Literature Review |
| title_full_unstemmed | Tracheobronchial Amyloidosis: A Rare Airway Disorder With Diagnostic and Therapeutic Challenges—A Case Report and Literature Review |
| title_short | Tracheobronchial Amyloidosis: A Rare Airway Disorder With Diagnostic and Therapeutic Challenges—A Case Report and Literature Review |
| title_sort | tracheobronchial amyloidosis a rare airway disorder with diagnostic and therapeutic challenges a case report and literature review |
| topic | airway obstruction bronchoscopy protein deposition therapeutic management tracheobronchial amyloidosis |
| url | https://doi.org/10.1002/rcr2.70171 |
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