Piezo1-Mediated Ferroptosis Delays Wound Healing in Aging Mice by Regulating the Transcriptional Activity of SLC7A11 through Activating Transcription Factor 3

Piezo1-Mediated Ferroptosis Delays Wound Healing in Aging Mice by Regulating the Transcriptional Activity of SLC7A11 through Activating Transcription Factor 3

Ferroptosis plays a role in wound healing during the maturation of senescent endothelial cells. This study explores the modulation of ferroptosis in senescent human umbilical vein endothelial cells (HUVECs) and wound-healing processes by Piezo1 activation at the molecular, cellular, and tissue level...

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Main Authors: Chen Jin, Du-piao Zhang, Zhen Lin, Yu-zhe Lin, Yi-feng Shi, Xiao-yu Dong, Meng-qi Jin, Fu-qiang Song, Si-ting Du, Yan-zhen Feng, Lin-yuan Jiang, Xiao-qiong Jiang, Abdullah Al Mamun, Zi-miao Chen, Jian Wang, Keqing Shi, Ren-wen Wan, Zhi-wen Luo, Zheng-lin Li, Lei Yang, Jian Xiao
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS) 2025-01-01
Series:Research
Online Access:https://spj.science.org/doi/10.34133/research.0718
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