ROMO1: A Distinct Mitochondrial Protein with Dual Roles in Dynamics and Function
Reactive oxygen species modulator 1 (ROMO1) is a nuclear-encoded inner mitochondrial protein known for its dual role as a modulator of reactive oxygen species (ROS) and a non-selective ion channel. Initially identified for its role in ROS production, ROMO1 has garnered attention for its functional p...
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MDPI AG
2025-04-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/14/5/540 |
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| author | Angel Yordanov Eva Tsoneva |
| author_facet | Angel Yordanov Eva Tsoneva |
| author_sort | Angel Yordanov |
| collection | DOAJ |
| description | Reactive oxygen species modulator 1 (ROMO1) is a nuclear-encoded inner mitochondrial protein known for its dual role as a modulator of reactive oxygen species (ROS) and a non-selective ion channel. Initially identified for its role in ROS production, ROMO1 has garnered attention for its functional properties as a non-selective ion channel that regulates ion homeostasis in mitochondria. This article examines ROMO1 from both perspectives, emphasizing its structural and functional characteristics, physiological roles, and implications in health and disease. Understanding ROMO1’s dual functionality provides insight into its potential as a therapeutic target for oxidative stress-related disorders, especially cancer progression. |
| format | Article |
| id | doaj-art-1ec27ed9e1af45d7baa01f8058a71221 |
| institution | OA Journals |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-1ec27ed9e1af45d7baa01f8058a712212025-08-20T02:33:36ZengMDPI AGAntioxidants2076-39212025-04-0114554010.3390/antiox14050540ROMO1: A Distinct Mitochondrial Protein with Dual Roles in Dynamics and FunctionAngel Yordanov0Eva Tsoneva1Department of Gynaecological Oncology, Medical University Pleven, 5800 Pleven, BulgariaDepartment of Reproductive Medicine, Specialized Hospital for Active Treatment of Obstetrics and Gynaecology Dr Shterev, 1330 Sofia, BulgariaReactive oxygen species modulator 1 (ROMO1) is a nuclear-encoded inner mitochondrial protein known for its dual role as a modulator of reactive oxygen species (ROS) and a non-selective ion channel. Initially identified for its role in ROS production, ROMO1 has garnered attention for its functional properties as a non-selective ion channel that regulates ion homeostasis in mitochondria. This article examines ROMO1 from both perspectives, emphasizing its structural and functional characteristics, physiological roles, and implications in health and disease. Understanding ROMO1’s dual functionality provides insight into its potential as a therapeutic target for oxidative stress-related disorders, especially cancer progression.https://www.mdpi.com/2076-3921/14/5/540ROMO1ROSoxidative stresscancercervical cancer |
| spellingShingle | Angel Yordanov Eva Tsoneva ROMO1: A Distinct Mitochondrial Protein with Dual Roles in Dynamics and Function Antioxidants ROMO1 ROS oxidative stress cancer cervical cancer |
| title | ROMO1: A Distinct Mitochondrial Protein with Dual Roles in Dynamics and Function |
| title_full | ROMO1: A Distinct Mitochondrial Protein with Dual Roles in Dynamics and Function |
| title_fullStr | ROMO1: A Distinct Mitochondrial Protein with Dual Roles in Dynamics and Function |
| title_full_unstemmed | ROMO1: A Distinct Mitochondrial Protein with Dual Roles in Dynamics and Function |
| title_short | ROMO1: A Distinct Mitochondrial Protein with Dual Roles in Dynamics and Function |
| title_sort | romo1 a distinct mitochondrial protein with dual roles in dynamics and function |
| topic | ROMO1 ROS oxidative stress cancer cervical cancer |
| url | https://www.mdpi.com/2076-3921/14/5/540 |
| work_keys_str_mv | AT angelyordanov romo1adistinctmitochondrialproteinwithdualrolesindynamicsandfunction AT evatsoneva romo1adistinctmitochondrialproteinwithdualrolesindynamicsandfunction |