CRBN modulates synuclein fibrillation via degradation of DNAJB1 in mouse model of Parkinson disease

CRBN modulates synuclein fibrillation via degradation of DNAJB1 in mouse model of Parkinson disease

Abstract Cereblon (CRBN) is a substrate recruiter for CRL4CRBN E3 ubiquitin ligase system playing a plethora of pivotal roles for biological systems. Here, we identified DNAJB1 (DJ1) as endogenous substrate of CRBN and report how CRBN influences the aggregation and toxicity of alpha-synuclein (α-SYN...

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Bibliographic Details
Main Authors: Uroos Akber, Jun-Hyung Jung, Heewoong Yoon, Jiwon Seo, Chul-Seung Park
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-024-00801-3
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