Case Report: Vanishing bile duct syndrome in Hodgkin’s lymphoma: a case highlighting jaundice and lymphadenopathy as early clues
Vanishing bile duct syndrome is a specific pathologic process characterized by ductopenia and intrahepatic cholestasis, which may be a unique paraneoplastic syndrome of Hodgkin’s lymphoma with an unfavorable prognosis. We report a 34-year-old woman with acute jaundice and lymphadenopathy, which was...
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| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1561110/full |
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| author | Shiyu Ma Dali Cai Yuan Miao Baocheng Deng Xiaojing Yan Ran Gao |
| author_facet | Shiyu Ma Dali Cai Yuan Miao Baocheng Deng Xiaojing Yan Ran Gao |
| author_sort | Shiyu Ma |
| collection | DOAJ |
| description | Vanishing bile duct syndrome is a specific pathologic process characterized by ductopenia and intrahepatic cholestasis, which may be a unique paraneoplastic syndrome of Hodgkin’s lymphoma with an unfavorable prognosis. We report a 34-year-old woman with acute jaundice and lymphadenopathy, which was subsequently confirmed to be Hodgkin’s lymphoma with concurrent vanishing bile duct syndrome based on a liver biopsy. The patient agreed to combination chemotherapy with brentuximab vedotin and achieved a complete response. Liver function recovered within 4 months. This article reviews the literature and provides insight for addressing similar clinical challenges. |
| format | Article |
| id | doaj-art-1ebcf3acd1964fa6bb3ac28effe3c57f |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-1ebcf3acd1964fa6bb3ac28effe3c57f2025-08-20T01:55:27ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-05-011610.3389/fimmu.2025.15611101561110Case Report: Vanishing bile duct syndrome in Hodgkin’s lymphoma: a case highlighting jaundice and lymphadenopathy as early cluesShiyu Ma0Dali Cai1Yuan Miao2Baocheng Deng3Xiaojing Yan4Ran Gao5Department of Hematology, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Hematology, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Pathology, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaThe Second Department of Infectious Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Hematology, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaDepartment of Hematology, The First Hospital of China Medical University, Shenyang, Liaoning, ChinaVanishing bile duct syndrome is a specific pathologic process characterized by ductopenia and intrahepatic cholestasis, which may be a unique paraneoplastic syndrome of Hodgkin’s lymphoma with an unfavorable prognosis. We report a 34-year-old woman with acute jaundice and lymphadenopathy, which was subsequently confirmed to be Hodgkin’s lymphoma with concurrent vanishing bile duct syndrome based on a liver biopsy. The patient agreed to combination chemotherapy with brentuximab vedotin and achieved a complete response. Liver function recovered within 4 months. This article reviews the literature and provides insight for addressing similar clinical challenges.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1561110/fulljaundiceHodgkin’s lymphomavanishing bile duct syndromeliver biopsybrentuximab vedotin (BV) |
| spellingShingle | Shiyu Ma Dali Cai Yuan Miao Baocheng Deng Xiaojing Yan Ran Gao Case Report: Vanishing bile duct syndrome in Hodgkin’s lymphoma: a case highlighting jaundice and lymphadenopathy as early clues Frontiers in Immunology jaundice Hodgkin’s lymphoma vanishing bile duct syndrome liver biopsy brentuximab vedotin (BV) |
| title | Case Report: Vanishing bile duct syndrome in Hodgkin’s lymphoma: a case highlighting jaundice and lymphadenopathy as early clues |
| title_full | Case Report: Vanishing bile duct syndrome in Hodgkin’s lymphoma: a case highlighting jaundice and lymphadenopathy as early clues |
| title_fullStr | Case Report: Vanishing bile duct syndrome in Hodgkin’s lymphoma: a case highlighting jaundice and lymphadenopathy as early clues |
| title_full_unstemmed | Case Report: Vanishing bile duct syndrome in Hodgkin’s lymphoma: a case highlighting jaundice and lymphadenopathy as early clues |
| title_short | Case Report: Vanishing bile duct syndrome in Hodgkin’s lymphoma: a case highlighting jaundice and lymphadenopathy as early clues |
| title_sort | case report vanishing bile duct syndrome in hodgkin s lymphoma a case highlighting jaundice and lymphadenopathy as early clues |
| topic | jaundice Hodgkin’s lymphoma vanishing bile duct syndrome liver biopsy brentuximab vedotin (BV) |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1561110/full |
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