Real-Time Precise Prediction Dispersion Turning Point of Optical Microfiber Coupler Biosensor with Ultra-High Sensitivity and Wide Linear Dynamic Range
Optical microfiber biosensors demonstrate exceptionally ultra-high sensitivity at the dispersion turning point (DTP). However, the DTP is highly susceptible to variations in dimensional and external environmental factors, and the spectral response is mismatched from preparation in air to application...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
|
| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/15/4/241 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849711980181454848 |
|---|---|
| author | Haiyang Yu Yue Wang Yang Xu Wenchao Zhou Yihui Wu |
| author_facet | Haiyang Yu Yue Wang Yang Xu Wenchao Zhou Yihui Wu |
| author_sort | Haiyang Yu |
| collection | DOAJ |
| description | Optical microfiber biosensors demonstrate exceptionally ultra-high sensitivity at the dispersion turning point (DTP). However, the DTP is highly susceptible to variations in dimensional and external environmental factors, and the spectral response is mismatched from preparation in air to application in a liquid environment, making the DTP difficult to control effectively. In this work, we propose a method that bridges the relationship between the interference spectra of air and aqueous environments. By counting the interference peaks in air, we can accurately predict the DTP position in liquids. Meanwhile, it provides a new balance between sensitivity and wide linear dynamic range, achieving wide dynamic range detection across various concentrations. The optical microfiber coupler (OMC) is fabricated using the hydrogen–oxygen flame melting tapering method. In addition, the concentration, temperature, and solvent used for the sensor’s biofunctional layer are optimized. Finally, in refractive index sensing, a maximum sensitivity of 1.17 × 105 ± 0.038 × 105 nm/RIU is achieved. For biosensing, a wide dynamic range detection of cardiac troponin I (cTnI) is realized at concentrations of 12–48 ng/mL, 120–480 pg/mL, and 120–480 fg/mL. |
| format | Article |
| id | doaj-art-1eb564e345f54db1a4539e8746eda0db |
| institution | DOAJ |
| issn | 2079-6374 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj-art-1eb564e345f54db1a4539e8746eda0db2025-08-20T03:14:27ZengMDPI AGBiosensors2079-63742025-04-0115424110.3390/bios15040241Real-Time Precise Prediction Dispersion Turning Point of Optical Microfiber Coupler Biosensor with Ultra-High Sensitivity and Wide Linear Dynamic RangeHaiyang Yu0Yue Wang1Yang Xu2Wenchao Zhou3Yihui Wu4Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, ChinaChangchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, ChinaChangchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, ChinaChangchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, ChinaChangchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, ChinaOptical microfiber biosensors demonstrate exceptionally ultra-high sensitivity at the dispersion turning point (DTP). However, the DTP is highly susceptible to variations in dimensional and external environmental factors, and the spectral response is mismatched from preparation in air to application in a liquid environment, making the DTP difficult to control effectively. In this work, we propose a method that bridges the relationship between the interference spectra of air and aqueous environments. By counting the interference peaks in air, we can accurately predict the DTP position in liquids. Meanwhile, it provides a new balance between sensitivity and wide linear dynamic range, achieving wide dynamic range detection across various concentrations. The optical microfiber coupler (OMC) is fabricated using the hydrogen–oxygen flame melting tapering method. In addition, the concentration, temperature, and solvent used for the sensor’s biofunctional layer are optimized. Finally, in refractive index sensing, a maximum sensitivity of 1.17 × 105 ± 0.038 × 105 nm/RIU is achieved. For biosensing, a wide dynamic range detection of cardiac troponin I (cTnI) is realized at concentrations of 12–48 ng/mL, 120–480 pg/mL, and 120–480 fg/mL.https://www.mdpi.com/2079-6374/15/4/241dispersion turning pointoptical microfiber coupler biosensormode interferenceultra-high sensitivitylinear dynamic range |
| spellingShingle | Haiyang Yu Yue Wang Yang Xu Wenchao Zhou Yihui Wu Real-Time Precise Prediction Dispersion Turning Point of Optical Microfiber Coupler Biosensor with Ultra-High Sensitivity and Wide Linear Dynamic Range Biosensors dispersion turning point optical microfiber coupler biosensor mode interference ultra-high sensitivity linear dynamic range |
| title | Real-Time Precise Prediction Dispersion Turning Point of Optical Microfiber Coupler Biosensor with Ultra-High Sensitivity and Wide Linear Dynamic Range |
| title_full | Real-Time Precise Prediction Dispersion Turning Point of Optical Microfiber Coupler Biosensor with Ultra-High Sensitivity and Wide Linear Dynamic Range |
| title_fullStr | Real-Time Precise Prediction Dispersion Turning Point of Optical Microfiber Coupler Biosensor with Ultra-High Sensitivity and Wide Linear Dynamic Range |
| title_full_unstemmed | Real-Time Precise Prediction Dispersion Turning Point of Optical Microfiber Coupler Biosensor with Ultra-High Sensitivity and Wide Linear Dynamic Range |
| title_short | Real-Time Precise Prediction Dispersion Turning Point of Optical Microfiber Coupler Biosensor with Ultra-High Sensitivity and Wide Linear Dynamic Range |
| title_sort | real time precise prediction dispersion turning point of optical microfiber coupler biosensor with ultra high sensitivity and wide linear dynamic range |
| topic | dispersion turning point optical microfiber coupler biosensor mode interference ultra-high sensitivity linear dynamic range |
| url | https://www.mdpi.com/2079-6374/15/4/241 |
| work_keys_str_mv | AT haiyangyu realtimeprecisepredictiondispersionturningpointofopticalmicrofibercouplerbiosensorwithultrahighsensitivityandwidelineardynamicrange AT yuewang realtimeprecisepredictiondispersionturningpointofopticalmicrofibercouplerbiosensorwithultrahighsensitivityandwidelineardynamicrange AT yangxu realtimeprecisepredictiondispersionturningpointofopticalmicrofibercouplerbiosensorwithultrahighsensitivityandwidelineardynamicrange AT wenchaozhou realtimeprecisepredictiondispersionturningpointofopticalmicrofibercouplerbiosensorwithultrahighsensitivityandwidelineardynamicrange AT yihuiwu realtimeprecisepredictiondispersionturningpointofopticalmicrofibercouplerbiosensorwithultrahighsensitivityandwidelineardynamicrange |