A Review of Edible Fruits from the Rosaceae Family: Rich Sources of Phytochemicals with Potent Anti-inflammatory Properties
Inflammation is one of the main causes of many non-infectious diseases like asthma, diabetes, and rheumatoid arthritis. Various inflammatory mediators and pathways are involved in the inflammation process. Also, overproduction of reactive oxygen species (ROS) under the stimulus of pro-inflammatory c...
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Iranian Society of Pharmacognosy
2025-04-01
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| Series: | Research Journal of Pharmacognosy |
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| Online Access: | https://www.rjpharmacognosy.ir/article_216468_e41e4b649422ec291230c94045f8fd8b.pdf |
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| author | Saeed Ghasemi Mahnaz Khanavi Fatemeh Yousefbeyk* |
| author_facet | Saeed Ghasemi Mahnaz Khanavi Fatemeh Yousefbeyk* |
| author_sort | Saeed Ghasemi |
| collection | DOAJ |
| description | Inflammation is one of the main causes of many non-infectious diseases like asthma, diabetes, and rheumatoid arthritis. Various inflammatory mediators and pathways are involved in the inflammation process. Also, overproduction of reactive oxygen species (ROS) under the stimulus of pro-inflammatory cytokines can lead to serious damages. The edible fruits from the Rosaceae family are commonly consumed in daily diets and contain phytochemicals with antioxidant and anti-inflammatory properties. Despite their numerous biological and clinical advantages, the application of Rosaceae fruit extracts in the formulation of pharmaceuticals for managing chronic inflammatory diseases is being neglected. This review will summarize the current state of knowledge on phytochemicals, in vitro, in vivo, and clinical studies of the most popular Rosaceae fruits. It will also highlight the suggested molecular mechanisms of action for their anti-inflammatory properties. The databases, including Web of Science, PubMed, Scopus, and Google Scholar were systematically searched with keywords such as phytochemical, anti-inflammatory, and the scientific name of each fruit. All studies support the antioxidant activity of Rosaceae fruits. In several studies, the inactivation of the NF-κB pathway was identified as the main anti-inflammatory mechanism of action. In many studies in vitro exposure to fruit extracts resulted in reducing the secretion of pro-inflammatory cytokines. Some studies also reported an increase in the secretion of IL-10 and a number of studies revealed the inhibitory effects of fruit extracts on COX-1 and COX-2. In conclusion, the potential of these extracts in formulating functional foods and pharmaceuticals to improve inflammatory conditions should be further explored. |
| format | Article |
| id | doaj-art-1eb4b485d628403b8f8a4cc104d39adf |
| institution | OA Journals |
| issn | 2345-4458 2345-5977 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Iranian Society of Pharmacognosy |
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| series | Research Journal of Pharmacognosy |
| spelling | doaj-art-1eb4b485d628403b8f8a4cc104d39adf2025-08-20T02:08:11ZengIranian Society of PharmacognosyResearch Journal of Pharmacognosy2345-44582345-59772025-04-01122779610.22127/rjp.2024.470060.2557216468A Review of Edible Fruits from the Rosaceae Family: Rich Sources of Phytochemicals with Potent Anti-inflammatory PropertiesSaeed Ghasemi0Mahnaz Khanavi1Fatemeh Yousefbeyk*2Department of Medicinal Chemistry, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran.Department of Pharmacognosy, Faculty of Pharmacy, and Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran.Department of Pharmacognosy, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran.Inflammation is one of the main causes of many non-infectious diseases like asthma, diabetes, and rheumatoid arthritis. Various inflammatory mediators and pathways are involved in the inflammation process. Also, overproduction of reactive oxygen species (ROS) under the stimulus of pro-inflammatory cytokines can lead to serious damages. The edible fruits from the Rosaceae family are commonly consumed in daily diets and contain phytochemicals with antioxidant and anti-inflammatory properties. Despite their numerous biological and clinical advantages, the application of Rosaceae fruit extracts in the formulation of pharmaceuticals for managing chronic inflammatory diseases is being neglected. This review will summarize the current state of knowledge on phytochemicals, in vitro, in vivo, and clinical studies of the most popular Rosaceae fruits. It will also highlight the suggested molecular mechanisms of action for their anti-inflammatory properties. The databases, including Web of Science, PubMed, Scopus, and Google Scholar were systematically searched with keywords such as phytochemical, anti-inflammatory, and the scientific name of each fruit. All studies support the antioxidant activity of Rosaceae fruits. In several studies, the inactivation of the NF-κB pathway was identified as the main anti-inflammatory mechanism of action. In many studies in vitro exposure to fruit extracts resulted in reducing the secretion of pro-inflammatory cytokines. Some studies also reported an increase in the secretion of IL-10 and a number of studies revealed the inhibitory effects of fruit extracts on COX-1 and COX-2. In conclusion, the potential of these extracts in formulating functional foods and pharmaceuticals to improve inflammatory conditions should be further explored.https://www.rjpharmacognosy.ir/article_216468_e41e4b649422ec291230c94045f8fd8b.pdfanti-inflammatory agentcytokinesfruitrosaceae |
| spellingShingle | Saeed Ghasemi Mahnaz Khanavi Fatemeh Yousefbeyk* A Review of Edible Fruits from the Rosaceae Family: Rich Sources of Phytochemicals with Potent Anti-inflammatory Properties Research Journal of Pharmacognosy anti-inflammatory agent cytokines fruit rosaceae |
| title | A Review of Edible Fruits from the Rosaceae Family: Rich Sources of Phytochemicals with Potent Anti-inflammatory Properties |
| title_full | A Review of Edible Fruits from the Rosaceae Family: Rich Sources of Phytochemicals with Potent Anti-inflammatory Properties |
| title_fullStr | A Review of Edible Fruits from the Rosaceae Family: Rich Sources of Phytochemicals with Potent Anti-inflammatory Properties |
| title_full_unstemmed | A Review of Edible Fruits from the Rosaceae Family: Rich Sources of Phytochemicals with Potent Anti-inflammatory Properties |
| title_short | A Review of Edible Fruits from the Rosaceae Family: Rich Sources of Phytochemicals with Potent Anti-inflammatory Properties |
| title_sort | review of edible fruits from the rosaceae family rich sources of phytochemicals with potent anti inflammatory properties |
| topic | anti-inflammatory agent cytokines fruit rosaceae |
| url | https://www.rjpharmacognosy.ir/article_216468_e41e4b649422ec291230c94045f8fd8b.pdf |
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