SIRT1/PGC-1α-mediated mitophagy participates the improvement roles of BMAL1 in podocytes injury in diabetic nephropathy: evidences from in vitro experiments

SIRT1/PGC-1α-mediated mitophagy participates the improvement roles of BMAL1 in podocytes injury in diabetic nephropathy: evidences from in vitro experiments

Abstract Background Dysfunction in podocyte mitophagy has been identified as a contributing factor to the onset and progression of diabetic nephropathy (DN), and BMAL1 plays an important role in the regulation of mitophagy. Thus, this study intended to examine the impact of BMAL1 on podocyte mitopha...

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Bibliographic Details
Main Authors: Yanxia Rui, Yinfeng Guo, Linying He, Min-er Wang, Henglan Wu
Format: Article
Language:English
Published: BMC 2025-01-01
Series:European Journal of Medical Research
Subjects:
BMAL1
Mitophagy
SIRT1/PGC-1α
Diabetic nephropathy
Podocyte injury
Online Access:https://doi.org/10.1186/s40001-025-02280-5
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