Development and validation of a UPLC-MS/MS method for the quantification of parsaclisib and its application to pharmacokinetics and metabolic stability studies

Development and validation of a UPLC-MS/MS method for the quantification of parsaclisib and its application to pharmacokinetics and metabolic stability studies

Abstract Parsaclisib is a novel, potent, highly selective, next-generation oral inhibitor of phosphatidylinositol 3-kinase δ (PI3Kδ) for patients with relapsed or refractory B-cell malignancies. However, there is no accurate and rapid method for the determination of parsaclisib. The aim of this stud...

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Bibliographic Details
Main Authors: Chenjian Zhou, Peiqi Wang, Jie Chen, Hualu Wu, Yige Yu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Chemistry
Subjects:
Parsaclisib
Pharmacokinetics
UPLC-MS/MS
Rats
Vitro
Online Access:https://doi.org/10.1186/s13065-025-01569-0
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