Selective Immunoglobulins deficiency in relatives antibody deficiency patient
Introduction: one of the most common inborn errors of immunity is selective IgA deficiency. Objetive: determine the prevalence of selective IgA deficiency in first-degree relatives of patients diagnosed with this immunological deficiency included in the registry of inborn errors of immunity in San...
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| Format: | Article |
| Language: | Spanish |
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Editorial Ciencias Médicas
2025-02-01
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| Series: | Acta Médica del Centro |
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| Online Access: | https://revactamedicacentro.sld.cu/index.php/amc/article/view/2055 |
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| author | Yralys Naranjo Herrera María del Carmen Chávez Alfonso Valia Concepción Ulloa Cándido Marcos León Márquez Grace Alicia De Lara García Ernesto Gabriel Caraballosa Yero |
| author_facet | Yralys Naranjo Herrera María del Carmen Chávez Alfonso Valia Concepción Ulloa Cándido Marcos León Márquez Grace Alicia De Lara García Ernesto Gabriel Caraballosa Yero |
| author_sort | Yralys Naranjo Herrera |
| collection | DOAJ |
| description | Introduction: one of the most common inborn errors of immunity is selective IgA deficiency.
Objetive: determine the prevalence of selective IgA deficiency in first-degree relatives of patients diagnosed with this immunological deficiency included in the registry of inborn errors of immunity in Sancti Spiritus province until 2023 year.
Methods: a cross-sectional descriptive study was carried out in Sancti Spiritus province from July 1st,2020 to December 31st, 2023.The population was made up of 36 first-degree relatives of the 15 patients with selective IgA deficiency diagnosed, included in the Provincial Registry of inborn errors of immunity. The three relatives with serum IgA dosage below normal values for their range of age were respondents.
Results: decreased IgA and IgG values were found only in some first-degree relatives and all showed IgM and CD3+CD4+T lymphocyte numbers within normal parameters. Female patients, adults and the mother as a predominated relative, most of them being asymptomatic.
Conclusions: In a fifth part of the families with selective IgA deficiency patient studied, new cases with this immunological deficiency appeared. Asymptomatic disease was the most frequent phenotype. |
| format | Article |
| id | doaj-art-1eac61fe7db94f45ac28773aaafbcde5 |
| institution | Kabale University |
| issn | 2709-7927 |
| language | Spanish |
| publishDate | 2025-02-01 |
| publisher | Editorial Ciencias Médicas |
| record_format | Article |
| series | Acta Médica del Centro |
| spelling | doaj-art-1eac61fe7db94f45ac28773aaafbcde52025-02-05T02:11:03ZspaEditorial Ciencias MédicasActa Médica del Centro2709-79272025-02-01191e2055e20551286Selective Immunoglobulins deficiency in relatives antibody deficiency patientYralys Naranjo Herrera0María del Carmen Chávez Alfonso1Valia Concepción Ulloa2Cándido Marcos León Márquez3Grace Alicia De Lara García4Ernesto Gabriel Caraballosa Yero5Hospital General Provincial “Camilo Cienfuegos”, Sancti Spíritus, CubaHospital General Provincial “Camilo Cienfuegos”, Sancti Spíritus, CubaHospital General Provincial “Camilo Cienfuegos”, Sancti Spíritus, CubaHospital General Provincial “Camilo Cienfuegos”, Sancti Spíritus, CubaHospital General “Tomas Carrera Galiano”, Trinidad, Sancti Spíritus, CubaHospital General Provincial “Camilo Cienfuegos”, Sancti Spíritus, CubaIntroduction: one of the most common inborn errors of immunity is selective IgA deficiency. Objetive: determine the prevalence of selective IgA deficiency in first-degree relatives of patients diagnosed with this immunological deficiency included in the registry of inborn errors of immunity in Sancti Spiritus province until 2023 year. Methods: a cross-sectional descriptive study was carried out in Sancti Spiritus province from July 1st,2020 to December 31st, 2023.The population was made up of 36 first-degree relatives of the 15 patients with selective IgA deficiency diagnosed, included in the Provincial Registry of inborn errors of immunity. The three relatives with serum IgA dosage below normal values for their range of age were respondents. Results: decreased IgA and IgG values were found only in some first-degree relatives and all showed IgM and CD3+CD4+T lymphocyte numbers within normal parameters. Female patients, adults and the mother as a predominated relative, most of them being asymptomatic. Conclusions: In a fifth part of the families with selective IgA deficiency patient studied, new cases with this immunological deficiency appeared. Asymptomatic disease was the most frequent phenotype.https://revactamedicacentro.sld.cu/index.php/amc/article/view/2055inmunodeficiencia selectiva de igafamiliares de primer grado |
| spellingShingle | Yralys Naranjo Herrera María del Carmen Chávez Alfonso Valia Concepción Ulloa Cándido Marcos León Márquez Grace Alicia De Lara García Ernesto Gabriel Caraballosa Yero Selective Immunoglobulins deficiency in relatives antibody deficiency patient Acta Médica del Centro inmunodeficiencia selectiva de iga familiares de primer grado |
| title | Selective Immunoglobulins deficiency in relatives antibody deficiency patient |
| title_full | Selective Immunoglobulins deficiency in relatives antibody deficiency patient |
| title_fullStr | Selective Immunoglobulins deficiency in relatives antibody deficiency patient |
| title_full_unstemmed | Selective Immunoglobulins deficiency in relatives antibody deficiency patient |
| title_short | Selective Immunoglobulins deficiency in relatives antibody deficiency patient |
| title_sort | selective immunoglobulins deficiency in relatives antibody deficiency patient |
| topic | inmunodeficiencia selectiva de iga familiares de primer grado |
| url | https://revactamedicacentro.sld.cu/index.php/amc/article/view/2055 |
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