Apelin-13 alleviates contrast-induced acute kidney injury by inhibiting endoplasmic reticulum stress
Contrast-induced acute kidney injury (CI-AKI) is a severe complication associated with significant morbidity and mortality, and effective therapeutic strategies are still lacking. Apelin is an endogenous physiological regulator with antioxidative, anti-inflammatory and antiapoptotic properties. Howe...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2179852 |
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| author | Qian Liu Shao-Bin Duan Lin Wang Xiao-Qin Luo Hong-Shen Wang Ying-Hao Deng Xi Wu Ting Wu Ping Yan and Yi-Xin Kang |
| author_facet | Qian Liu Shao-Bin Duan Lin Wang Xiao-Qin Luo Hong-Shen Wang Ying-Hao Deng Xi Wu Ting Wu Ping Yan and Yi-Xin Kang |
| author_sort | Qian Liu |
| collection | DOAJ |
| description | Contrast-induced acute kidney injury (CI-AKI) is a severe complication associated with significant morbidity and mortality, and effective therapeutic strategies are still lacking. Apelin is an endogenous physiological regulator with antioxidative, anti-inflammatory and antiapoptotic properties. However, the role of apelin-13 in CI-AKI remains unclear. In our study, we found that the protein expression levels of apelin were significantly downregulated in rat kidney tissues and HK-2 cells during contrast media treatment. Moreover, we explored the protective effect of apelin-13 on renal tubule damage using in vitro and in vivo models of CI-AKI. Exogenous apelin-13 ameliorated endoplasmic reticulum stress, reactive oxygen species and apoptosis protein expression in contrast media-treated cells and rat kidney tissues. Mechanistically, the downregulation of endoplasmic reticulum stress contributed critically to the antiapoptotic effect of apelin-13. Collectively, our findings reveal the inherent mechanisms by which apelin-13 regulates CI-AKI and provide a prospective target for the prevention of CI-AKI. |
| format | Article |
| id | doaj-art-1eabfd0122f8460a954aeb3eaf9fe4dc |
| institution | OA Journals |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-1eabfd0122f8460a954aeb3eaf9fe4dc2025-08-20T02:28:54ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492023-12-0145110.1080/0886022X.2023.2179852Apelin-13 alleviates contrast-induced acute kidney injury by inhibiting endoplasmic reticulum stressQian Liu0Shao-Bin Duan1Lin Wang2Xiao-Qin Luo3Hong-Shen Wang4Ying-Hao Deng5Xi Wu6Ting Wu7Ping Yan and8Yi-Xin Kang9Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital of Central South University, Changsha 410011, ChinaDepartment of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital of Central South University, Changsha 410011, ChinaDepartment of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital of Central South University, Changsha 410011, ChinaDepartment of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital of Central South University, Changsha 410011, ChinaDepartment of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital of Central South University, Changsha 410011, ChinaDepartment of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital of Central South University, Changsha 410011, ChinaDepartment of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital of Central South University, Changsha 410011, ChinaDepartment of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital of Central South University, Changsha 410011, ChinaDepartment of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital of Central South University, Changsha 410011, ChinaDepartment of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital of Central South University, Changsha 410011, ChinaContrast-induced acute kidney injury (CI-AKI) is a severe complication associated with significant morbidity and mortality, and effective therapeutic strategies are still lacking. Apelin is an endogenous physiological regulator with antioxidative, anti-inflammatory and antiapoptotic properties. However, the role of apelin-13 in CI-AKI remains unclear. In our study, we found that the protein expression levels of apelin were significantly downregulated in rat kidney tissues and HK-2 cells during contrast media treatment. Moreover, we explored the protective effect of apelin-13 on renal tubule damage using in vitro and in vivo models of CI-AKI. Exogenous apelin-13 ameliorated endoplasmic reticulum stress, reactive oxygen species and apoptosis protein expression in contrast media-treated cells and rat kidney tissues. Mechanistically, the downregulation of endoplasmic reticulum stress contributed critically to the antiapoptotic effect of apelin-13. Collectively, our findings reveal the inherent mechanisms by which apelin-13 regulates CI-AKI and provide a prospective target for the prevention of CI-AKI.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2179852Acute kidney injurycontrast mediaapelin-13endoplasmic reticulum stressreactive oxygen species |
| spellingShingle | Qian Liu Shao-Bin Duan Lin Wang Xiao-Qin Luo Hong-Shen Wang Ying-Hao Deng Xi Wu Ting Wu Ping Yan and Yi-Xin Kang Apelin-13 alleviates contrast-induced acute kidney injury by inhibiting endoplasmic reticulum stress Renal Failure Acute kidney injury contrast media apelin-13 endoplasmic reticulum stress reactive oxygen species |
| title | Apelin-13 alleviates contrast-induced acute kidney injury by inhibiting endoplasmic reticulum stress |
| title_full | Apelin-13 alleviates contrast-induced acute kidney injury by inhibiting endoplasmic reticulum stress |
| title_fullStr | Apelin-13 alleviates contrast-induced acute kidney injury by inhibiting endoplasmic reticulum stress |
| title_full_unstemmed | Apelin-13 alleviates contrast-induced acute kidney injury by inhibiting endoplasmic reticulum stress |
| title_short | Apelin-13 alleviates contrast-induced acute kidney injury by inhibiting endoplasmic reticulum stress |
| title_sort | apelin 13 alleviates contrast induced acute kidney injury by inhibiting endoplasmic reticulum stress |
| topic | Acute kidney injury contrast media apelin-13 endoplasmic reticulum stress reactive oxygen species |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2179852 |
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