NGAL: An Upcoming Biomarker of Interest
Aim: Neutrophil gelatinase-associated lipocalin (NGAL) performs important functions in the body. It has the potential to act as a diagnostic and prognostic biomarker for various diseases. Background: The role of NGAL has been well explored in acute and chronic kidney diseases (CKDs). It is considere...
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| Format: | Article |
| Language: | English |
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Jaypee Brothers Medical Publisher
2023-01-01
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| Series: | Indian Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://www.ijmb.in/doi/IJMB/pdf/10.5005/jp-journals-10054-0206 |
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| author | Khushboo Jasotani Kiran Dahiya Raunak Ahlawat Mohit Gupta Sushil Kumar Rakesh Dhankhar Pragati Singh |
| author_facet | Khushboo Jasotani Kiran Dahiya Raunak Ahlawat Mohit Gupta Sushil Kumar Rakesh Dhankhar Pragati Singh |
| author_sort | Khushboo Jasotani |
| collection | DOAJ |
| description | Aim: Neutrophil gelatinase-associated lipocalin (NGAL) performs important functions in the body. It has the potential to act as a diagnostic and prognostic biomarker for various diseases.
Background: The role of NGAL has been well explored in acute and chronic kidney diseases (CKDs). It is considered a maker for acute kidney injury (AKI). Its role in other diseases has also been increasingly reported.
Results: Neutrophil gelatinase-associated lipocalin takes part in the pathogenesis of several diseases, besides renal diseases, like cardiovascular diseases, inflammatory disorders, cancer, diabetes, etc. by a variety of mechanisms. Its levels have been correlated with the severity in most of the diseases.
Conclusion: Neutrophil gelatinase-associated lipocalin can act as a biomarker in different diseases though, its potential is yet to be explored to the maximum.
Clinical significance: Estimating the levels of NGAL in body fluids will help in making an early diagnosis, assessing the severity of the disease, establishing a prognosis, and improving the overall management of different diseases. |
| format | Article |
| id | doaj-art-1eaabcdc641545d98b9c3795441d5f9f |
| institution | OA Journals |
| issn | 0972-1207 2456-5164 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Jaypee Brothers Medical Publisher |
| record_format | Article |
| series | Indian Journal of Medical Biochemistry |
| spelling | doaj-art-1eaabcdc641545d98b9c3795441d5f9f2025-08-20T02:17:41ZengJaypee Brothers Medical PublisherIndian Journal of Medical Biochemistry0972-12072456-51642023-01-01261263010.5005/jp-journals-10054-02065NGAL: An Upcoming Biomarker of InterestKhushboo Jasotani0Kiran Dahiya1Raunak Ahlawat2Mohit Gupta3Sushil Kumar4Rakesh Dhankhar5Pragati Singh6Department of Biochemistry, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, IndiaKiran Dahiya, Department of Biochemistry, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India, Phone: +91 9896111985Department of Pathology, Maulana Azad Medical College, New Delhi, IndiaDepartment of Cardiothoracic Surgery, National Heart Institute, New Delhi, IndiaDepartment of Biochemistry, NC Medical College & Hospital, Panipat, Haryana, IndiaDepartment of Radiation Oncology, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, IndiaDepartment of Biochemistry, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, IndiaAim: Neutrophil gelatinase-associated lipocalin (NGAL) performs important functions in the body. It has the potential to act as a diagnostic and prognostic biomarker for various diseases. Background: The role of NGAL has been well explored in acute and chronic kidney diseases (CKDs). It is considered a maker for acute kidney injury (AKI). Its role in other diseases has also been increasingly reported. Results: Neutrophil gelatinase-associated lipocalin takes part in the pathogenesis of several diseases, besides renal diseases, like cardiovascular diseases, inflammatory disorders, cancer, diabetes, etc. by a variety of mechanisms. Its levels have been correlated with the severity in most of the diseases. Conclusion: Neutrophil gelatinase-associated lipocalin can act as a biomarker in different diseases though, its potential is yet to be explored to the maximum. Clinical significance: Estimating the levels of NGAL in body fluids will help in making an early diagnosis, assessing the severity of the disease, establishing a prognosis, and improving the overall management of different diseases.https://www.ijmb.in/doi/IJMB/pdf/10.5005/jp-journals-10054-0206biomarkerdiseasesneutrophil gelatinase-associated lipocalinlipocalins |
| spellingShingle | Khushboo Jasotani Kiran Dahiya Raunak Ahlawat Mohit Gupta Sushil Kumar Rakesh Dhankhar Pragati Singh NGAL: An Upcoming Biomarker of Interest Indian Journal of Medical Biochemistry biomarker diseases neutrophil gelatinase-associated lipocalin lipocalins |
| title | NGAL: An Upcoming Biomarker of Interest |
| title_full | NGAL: An Upcoming Biomarker of Interest |
| title_fullStr | NGAL: An Upcoming Biomarker of Interest |
| title_full_unstemmed | NGAL: An Upcoming Biomarker of Interest |
| title_short | NGAL: An Upcoming Biomarker of Interest |
| title_sort | ngal an upcoming biomarker of interest |
| topic | biomarker diseases neutrophil gelatinase-associated lipocalin lipocalins |
| url | https://www.ijmb.in/doi/IJMB/pdf/10.5005/jp-journals-10054-0206 |
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