Novel therapy modalities combining photodynamic therapy and liposomal cisplatin for pancreatic cancer treatments
Combination therapy is the mainstream cancer treatment to achieve the best clinical benefits for patients. Photodynamic therapy (PDT) can improve vascular permeability and enhance nanoparticle uptake in tumors with drug delivery permeability and retention effects. PDT can also minimize tissue damage...
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Elsevier
2025-03-01
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| Series: | Nano Trends |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666978125000133 |
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| author | Jia-Haur Chen John Vincent Lim Yih-Chih Hsu |
| author_facet | Jia-Haur Chen John Vincent Lim Yih-Chih Hsu |
| author_sort | Jia-Haur Chen |
| collection | DOAJ |
| description | Combination therapy is the mainstream cancer treatment to achieve the best clinical benefits for patients. Photodynamic therapy (PDT) can improve vascular permeability and enhance nanoparticle uptake in tumors with drug delivery permeability and retention effects. PDT can also minimize tissue damage compared with traditional chemotherapy. Therefore, it is beneficial to use PDT with chemotherapeutic administrations to obtain these benefits. Cisplatin (CDDP) is a widely used chemotherapeutic drug with strong toxic side effects such as nephrotoxicity and neurotoxicity. Our novel study is the first original study to investigate PDT with novel lipid-platinum chloride (LPC) nanoparticles to prove the results of greater efficacy and minimal side effects. In the in vitro study, CDDP and LPC nanoparticles enhanced higher amounts of cell death as the concentration increased. The treatment effects of PDT+LPC NPs using pancreatic MIAPaCa-2 and PANC-1 tumor models revealed that PDT+LPC significantly inhibited tumor growth. The body weight of all animals increased with animals showing no side effects. IHC assays for Ki-67, CD31, and cleaved caspase-3, TUNEL assays and western blot assays showed consistent results. Collectively, the combined PDT with LPC nanoparticles showed significant therapeutic outcomes with promising potential for clinical applications. |
| format | Article |
| id | doaj-art-1ea9abda9b63443fbdd2d2f66878408c |
| institution | Kabale University |
| issn | 2666-9781 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Nano Trends |
| spelling | doaj-art-1ea9abda9b63443fbdd2d2f66878408c2025-02-09T05:01:37ZengElsevierNano Trends2666-97812025-03-019100084Novel therapy modalities combining photodynamic therapy and liposomal cisplatin for pancreatic cancer treatmentsJia-Haur Chen0John Vincent Lim1Yih-Chih Hsu2Graduate Program of Bioscience Technology, Chung Yuan Christian University, Chungli, Taoyuan, 32023, TaiwanGraduate Program of Bioscience Technology, Chung Yuan Christian University, Chungli, Taoyuan, 32023, TaiwanDepartment of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, 6T 1Z3, Canada; Department of Bioscience Technology, Chung Yuan Christian University, Chungli, Taoyuan, 32023, Taiwan; Center for Research and Development of Commercialization of Cancer Theranostics, Chungli, Chung Yuan Christian University, Chungli, Taoyuan, 32023, Taiwan; Center of Nanotechnology, Chung Yuan Christian University, Chungli, Taoyuan, 32023, Taiwan; Corresponding author at: Department of Pharmaceutical Sciences, The University of British Columbia, Vancouver, Canada.; Corresponding author at: Department of Bioscience Technology, Chung Yuan Christian University, Taiwan.Combination therapy is the mainstream cancer treatment to achieve the best clinical benefits for patients. Photodynamic therapy (PDT) can improve vascular permeability and enhance nanoparticle uptake in tumors with drug delivery permeability and retention effects. PDT can also minimize tissue damage compared with traditional chemotherapy. Therefore, it is beneficial to use PDT with chemotherapeutic administrations to obtain these benefits. Cisplatin (CDDP) is a widely used chemotherapeutic drug with strong toxic side effects such as nephrotoxicity and neurotoxicity. Our novel study is the first original study to investigate PDT with novel lipid-platinum chloride (LPC) nanoparticles to prove the results of greater efficacy and minimal side effects. In the in vitro study, CDDP and LPC nanoparticles enhanced higher amounts of cell death as the concentration increased. The treatment effects of PDT+LPC NPs using pancreatic MIAPaCa-2 and PANC-1 tumor models revealed that PDT+LPC significantly inhibited tumor growth. The body weight of all animals increased with animals showing no side effects. IHC assays for Ki-67, CD31, and cleaved caspase-3, TUNEL assays and western blot assays showed consistent results. Collectively, the combined PDT with LPC nanoparticles showed significant therapeutic outcomes with promising potential for clinical applications.http://www.sciencedirect.com/science/article/pii/S2666978125000133Pancreatic cancerPhotodynamic therapyLiposomal cisplatinDrug delivery |
| spellingShingle | Jia-Haur Chen John Vincent Lim Yih-Chih Hsu Novel therapy modalities combining photodynamic therapy and liposomal cisplatin for pancreatic cancer treatments Nano Trends Pancreatic cancer Photodynamic therapy Liposomal cisplatin Drug delivery |
| title | Novel therapy modalities combining photodynamic therapy and liposomal cisplatin for pancreatic cancer treatments |
| title_full | Novel therapy modalities combining photodynamic therapy and liposomal cisplatin for pancreatic cancer treatments |
| title_fullStr | Novel therapy modalities combining photodynamic therapy and liposomal cisplatin for pancreatic cancer treatments |
| title_full_unstemmed | Novel therapy modalities combining photodynamic therapy and liposomal cisplatin for pancreatic cancer treatments |
| title_short | Novel therapy modalities combining photodynamic therapy and liposomal cisplatin for pancreatic cancer treatments |
| title_sort | novel therapy modalities combining photodynamic therapy and liposomal cisplatin for pancreatic cancer treatments |
| topic | Pancreatic cancer Photodynamic therapy Liposomal cisplatin Drug delivery |
| url | http://www.sciencedirect.com/science/article/pii/S2666978125000133 |
| work_keys_str_mv | AT jiahaurchen noveltherapymodalitiescombiningphotodynamictherapyandliposomalcisplatinforpancreaticcancertreatments AT johnvincentlim noveltherapymodalitiescombiningphotodynamictherapyandliposomalcisplatinforpancreaticcancertreatments AT yihchihhsu noveltherapymodalitiescombiningphotodynamictherapyandliposomalcisplatinforpancreaticcancertreatments |